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Entry version 63 (05 Jun 2019)
Sequence version 1 (04 Dec 2007)
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Protein
Submitted name:

Transient receptor potential ion channel protein

Gene

TRP2

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channelSAAS annotation, ReceptorImported
Biological processIon transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transient receptor potential ion channel proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRP2Imported
ORF Names:CHLREDRAFT_193017Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3055 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1389 – 1416HelicalSequence analysisAdd BLAST28
Transmembranei1497 – 1519HelicalSequence analysisAdd BLAST23
Transmembranei1539 – 1555HelicalSequence analysisAdd BLAST17
Transmembranei1576 – 1594HelicalSequence analysisAdd BLAST19
Transmembranei1600 – 1621HelicalSequence analysisAdd BLAST22
Transmembranei1642 – 1662HelicalSequence analysisAdd BLAST21
Transmembranei1703 – 1726HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8J8F8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini597 – 742ANK_REP_REGIONInterPro annotationAdd BLAST146
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati685 – 717ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1853 – 1881DisorderedSequence analysisAdd BLAST29
Regioni1934 – 1955DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili214 – 234Sequence analysisAdd BLAST21
Coiled coili259 – 293Sequence analysisAdd BLAST35

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J5C1 Eukaryota
ENOG410ZK2A LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8J8F8

Database of Orthologous Groups

More...
OrthoDBi
140101at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR024862 TRPV

The PANTHER Classification System

More...
PANTHERi
PTHR10582 PTHR10582, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8J8F8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRQRQSIHQ SIEANKSAFP YSPGNCGARA APSCCSVTAA LAWLILRQMR
60 70 80 90 100
PPRRHYVEDA KKLLVVGDTR RCIMTCANEV KFWGYCKDLW RDDPGLDTQP
110 120 130 140 150
QQLQGKGAAA GPVGQAAGRN CTCKQYDDRA MNATSVQGFI RRTDADGKPS
160 170 180 190 200
LHPVMLYVTS RAVKAEDEVL LHWDKKGEFF RAITEAASGY QFHLGVLRLA
210 220 230 240 250
AYAERGWVRE ARLRRELEQE VQRLTAHIDF LDQAGRKAQA VQHSESGARL
260 270 280 290 300
KLGGLQAELV ALQMDNQRKQ HQIEYLERQL VQARSDLNLL RVEEPNGAGD
310 320 330 340 350
HAADTAAADA AGGGDFVYDD HDQYGGEYDG GYDDGYDGRP MRTSSTPLLL
360 370 380 390 400
ASSSSRSSTG WVKAVRLQGG GQRRCDGGDG GFAWSGLVCA HGGQLLLSLP
410 420 430 440 450
LTVAAPASAS SCLLSAAMGP SSRSNRSSIS RSGMIGDVGH IRFSSSRCAS
460 470 480 490 500
SSPLAPASLP ASGSTSSSCA TRELSMYRSP ATYLPVKPGP DSWSDILSPP
510 520 530 540 550
SRGTARSRSV SPASERKCYA LVRQNAALEV VAATVAPEYL AFPSSRLVLA
560 570 580 590 600
RFYDIVASSS EYLQEIAEIH SLCQAEDFLI AREEDPGFTL LHYVAMLGHT
610 620 630 640 650
TLADAIQAAT PEAMHRFSRL ARYLVRRNHD VTYVVDKYGC IPLQCAAAYG
660 670 680 690 700
NSEMVGVLLE PYDNPVNRKD TNKRNEYLNH QDTQIRFTAL HGALLHGQHE
710 720 730 740 750
VAVLLLESGA NPQILDITRN NAFQVAPSLE SLQELLRIVV QHEDVVPEWA
760 770 780 790 800
KALSSSNMDY TQRMLFVAIN QLVNKVAEAG GEVGSIIKRL FKELYTKGEG
810 820 830 840 850
KYGDLWEYVQ AAVSYNNYKL SKIMLDLISA ECPRALSSCN WEATMGPLIA
860 870 880 890 900
CFPDLFHTLL CKLQDMSDSE VSLSLARGAK GAAHQGKILI YQQLVEGLKA
910 920 930 940 950
VNYVVVKAFF EKADQHVLND MAQYPIFKDF ASLIANKRTA EGFTESDSGR
960 970 980 990 1000
SRLLDLLRDV KRNSLAEEHY RPQADILNRH RALSMKFRNS GKSTHGGNAF
1010 1020 1030 1040 1050
NGNASRRSRV GLDAAAAAIA EDEAADGAGK DIAKERSAPA GMMVVRKLSN
1060 1070 1080 1090 1100
ELAVQTLNVE RVLWAAVAAR KSMNVDAAVK SIISWVNLNS KDRRAVFVTG
1110 1120 1130 1140 1150
ISTDLLKELA LRFPSGCAKL LNLVSRDVLE QLATLQVSAN LLHRKDQLVK
1160 1170 1180 1190 1200
CSDVRNHFTW RAPELQHLSD EKGYSEHVVD ALADYGIPFE CTYKAAVEWD
1210 1220 1230 1240 1250
TSREHFAVLI ENHFTGAELK ELISNGILLS RVVDMIARCA KPPEDVPGFK
1260 1270 1280 1290 1300
AEPMTQLIKE MLREKLSFRI IEAILDAGSM NEATVYTNFR PGNPLYNIYP
1310 1320 1330 1340 1350
LKLYKPVYTH HFVQLLLTNW RKGTKDAQGH WTLRPWDKKF IDTIYAPNDP
1360 1370 1380 1390 1400
LCTALKSAYD NKLKDTQVYI ENSQAMEGWA KKQRQNQNLV LSAFVCNPLL
1410 1420 1430 1440 1450
LHRWPVFVLM HILLYIRDTV KAWWRHVGWE WDAWGDQHGH SVDARALVIP
1460 1470 1480 1490 1500
WKGVADLGSV KGILTGLIDV DVPVRWFGFA AVKAAITVQW QEFGQMLMLM
1510 1520 1530 1540 1550
SALAHIIFMS LFGGFLLVMR NAGEQENGDM SKVNSQPEIM ALLVVLGLMS
1560 1570 1580 1590 1600
VGGLAEEVSQ MMELTWRTWR NYLGNLVDLA SFALFMVLFG MVWASYTYDV
1610 1620 1630 1640 1650
ILAVGAIETL VLFVRLVFFA SMTDSMGSLM RMVIEIIKDM RYFFALLAMI
1660 1670 1680 1690 1700
FGGFAIAFAV LLGESNTYEA VAFKLFSVML GDWQYDYLLD MIYVEHAWYV
1710 1720 1730 1740 1750
SRLSVLMMSA YGILMLIVLV NLLIAIMNDT YDRIKETEEI EVLHNRARLI
1760 1770 1780 1790 1800
VDLESLLTKD MRDKLQERLL GDYLHVLVPA DKKFNKFMAS SESTDGEWKG
1810 1820 1830 1840 1850
RMRAFMEAIK RTVDPQLRDI RDKNAAEFKL INSELDYIRK WVVEQKRMMG
1860 1870 1880 1890 1900
PLHGGDDEGM HGGHGGGHER AGSSLALGRR PTSANCTTFE PAPLLLPVAK
1910 1920 1930 1940 1950
GLWSAAACQG PAWQGSSSQV TPFMPVTVAQ HRNVTGKDSG LPSSAGSLGN

RSAWS
Length:1,955
Mass (Da):216,899
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0A821F87E84788F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS496144 Genomic DNA Translation: EDO99708.1

NCBI Reference Sequences

More...
RefSeqi
XP_001697825.1, XM_001697773.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5723452

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cre:CHLREDRAFT_193017

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS496144 Genomic DNA Translation: EDO99708.1
RefSeqiXP_001697825.1, XM_001697773.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiA8J8F8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5723452
KEGGicre:CHLREDRAFT_193017

Phylogenomic databases

eggNOGiENOG410J5C1 Eukaryota
ENOG410ZK2A LUCA
InParanoidiA8J8F8
OrthoDBi140101at2759

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR024862 TRPV
PANTHERiPTHR10582 PTHR10582, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8J8F8_CHLRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8J8F8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: June 5, 2019
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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