Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 74 (29 Sep 2021)
Sequence version 1 (04 Dec 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Proton/sulfate cotransporter 2

Gene

SULTR2

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

H+/sulfate cotransporter with a probable high-affinity for sulfate and a proteasome independent turnover.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processStress response, Sulfate transport, Symport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.53.1.8, the sulfate permease (sulp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proton/sulfate cotransporter 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SULTR2
ORF Names:CHLREDRAFT_150514
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3055 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeChlorophytacore chlorophytesChlorophyceaeCS cladeChlamydomonadalesChlamydomonadaceaeChlamydomonas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No effect on sulfate uptake, due to the redundancy with SLT1 and SLTR2. Slt1 and sultr2 double mutants, as well as slt2 and sultr2 show a 50% decline in uptake while the slt1, slt2 and sultr2 triple mutant exhibits no increase in sulfate uptake capacity when deprived of sulfur.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004171271 – 764Proton/sulfate cotransporter 2Add BLAST764

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8J6J0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by sulfur deprivation.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3055.EDP00477

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini542 – 664STASPROSITE-ProRule annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni678 – 764DisorderedSequence analysisAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi694 – 722Polar residuesSequence analysisAdd BLAST29
Compositional biasi741 – 764Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0236, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003182_13_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8J6J0

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWHLLAN

Database of Orthologous Groups

More...
OrthoDBi
690428at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.750.24, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR002645, STAS_dom
IPR036513, STAS_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11814, PTHR11814, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01740, STAS, 1 hit
PF00916, Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52091, SSF52091, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00815, sulP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50801, STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8J6J0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRNTSNVDT GGVPAPLNST PSTRLIQNGY GDSKYETERM EFPFPEDPRY
60 70 80 90 100
HPRDSVKGAW EKVKEDHHHR VATYNWVDWL AFFIPCVRWL RTYRRSYLLN
110 120 130 140 150
DIVAGISVGF MVVPQGLSYA NLAGLPSVYG LYGAFLPCIV YSLVGSSRQL
160 170 180 190 200
AVGPVAVTSL LLGTKLKDIL PEAAGISNPN IPGSPELDAV QEKYNRLAIQ
210 220 230 240 250
LAFLVACLYT GVGIFRLGFV TNFLSHAVIG GFTSGAAITI GLSQVKYILG
260 270 280 290 300
ISIPRQDRLQ DQAKTYVDNM HNMKWQEFIM GTTFLFLLVL FKEVGKRSKR
310 320 330 340 350
FKWLRPIGPL TVCIIGLCAV YVGNVQNKGI KIIGAIKAGL PAPTVSWWFP
360 370 380 390 400
MPEISQLFPT AIVVMLVDLL ESTSIARALA RKNKYELHAN QEIVGLGLAN
410 420 430 440 450
FAGAIFNCYT TTGSFSRSAV NNESGAKTGL ACFITAWVVG FVLIFLTPVF
460 470 480 490 500
AHLPYCTLGA IIVSSIVGLL EYEQAIYLWK VNKLDWLVWM ASFLGVLFIS
510 520 530 540 550
VEIGLGIAIG LAILIVIYES AFPNTALVGR IPGTTIWRNI KQYPNAQLAP
560 570 580 590 600
GLLVFRIDAP IYFANIQWIK ERLEGFASAH RVWSQEHGVP LEYVILDFSP
610 620 630 640 650
VTHIDATGLH TLETIVETLA GHGTQVVLAN PSQEIIALMR RGGLFDMIGR
660 670 680 690 700
DYVFITVNEA VTFCSRQMAE RGYAVKEDNT SSYPHFGSRR TPGALPAPSS
710 720 730 740 750
QLDSSPPTSV TESTSGTPAA GTYSSIGGAV PAVAGHTAAG NGGSHSPSAQ
760
PGVQLTTTGS QRQQ
Length:764
Mass (Da):83,230
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i050C75A8A9DAFDCA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GU181277 mRNA Translation: ACZ63170.1
DS496139 Genomic DNA Translation: EDP00477.1

NCBI Reference Sequences

More...
RefSeqi
XP_001697222.1, XM_001697170.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
PNW70519; PNW70519; CHLRE_17g723350v5

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5722730

Gramene; a comparative resource for plants

More...
Gramenei
PNW70519; PNW70519; CHLRE_17g723350v5

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cre:CHLREDRAFT_150514

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU181277 mRNA Translation: ACZ63170.1
DS496139 Genomic DNA Translation: EDP00477.1
RefSeqiXP_001697222.1, XM_001697170.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3055.EDP00477

Protein family/group databases

TCDBi2.A.53.1.8, the sulfate permease (sulp) family

Proteomic databases

PaxDbiA8J6J0

Genome annotation databases

EnsemblPlantsiPNW70519; PNW70519; CHLRE_17g723350v5
GeneIDi5722730
GrameneiPNW70519; PNW70519; CHLRE_17g723350v5
KEGGicre:CHLREDRAFT_150514

Phylogenomic databases

eggNOGiKOG0236, Eukaryota
HOGENOMiCLU_003182_13_2_1
InParanoidiA8J6J0
OMAiKWHLLAN
OrthoDBi690428at2759

Family and domain databases

Gene3Di3.30.750.24, 1 hit
InterProiView protein in InterPro
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR002645, STAS_dom
IPR036513, STAS_dom_sf
PANTHERiPTHR11814, PTHR11814, 1 hit
PfamiView protein in Pfam
PF01740, STAS, 1 hit
PF00916, Sulfate_transp, 1 hit
SUPFAMiSSF52091, SSF52091, 1 hit
TIGRFAMsiTIGR00815, sulP, 1 hit
PROSITEiView protein in PROSITE
PS50801, STAS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSULT2_CHLRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8J6J0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: December 4, 2007
Last modified: September 29, 2021
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again