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Entry version 71 (10 Apr 2019)
Sequence version 1 (04 Dec 2007)
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Protein
Submitted name:

Dicer-like protein

Gene

DCL1

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: InterPro
  • ribonuclease III activity Source: GO_Central
  • RNA binding Source: UniProtKB-UniRule

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dicer-like proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCL1Imported
ORF Names:CHLREDRAFT_173928Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3055 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8J0M8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3055.EDP02111

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A8J0M8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 191Helicase ATP-bindingInterPro annotationAdd BLAST176
Domaini575 – 749Helicase C-terminalInterPro annotationAdd BLAST175
Domaini785 – 882Dicer dsRNA-binding foldInterPro annotationAdd BLAST98
Domaini1388 – 1503RNase IIIInterPro annotationAdd BLAST116
Domaini1641 – 1713RNase IIIInterPro annotationAdd BLAST73

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0701 Eukaryota
COG1111 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8J0M8

KEGG Orthology (KO)

More...
KOi
K11592

Database of Orthologous Groups

More...
OrthoDBi
1337630at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 2 hits
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF00636 Ribonuclease_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00535 RIBOc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8J0M8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTALPPLRE YQAELLRMAR RHASTVIYAE TGTGKTRIAV ERILEAHGEL
60 70 80 90 100
VAAGRLAAFL APTVPLVRQQ AEVLVAAGLR VVVYTGEDNR DARNRAGWQR
110 120 130 140 150
LHQEADVLCA TPDALNRLIA HAFITIPQLG MIVFDECHHT NANHPYAVLL
160 170 180 190 200
RVFVRHLTPP DQRPVLLGLT ASPHKADELM RLLGAQMVAA SNTAQLQTFM
210 220 230 240 250
AKPRVEVHRQ EVEQPATVAP PQRRLASGTF SAAASILPPE CAAAVASGDA
260 270 280 290 300
ADMRKAGEAL HAGGGSCIAA QPMAALDGAI ELVSAAVEYS RCRDQTFRRC
310 320 330 340 350
CALGEPLPEM RAPRYTSPLL RGMETPQRWW EQDPQCGTKH LEHLRSQLAG
360 370 380 390 400
VKDALSSMGL WPAVAVAAAD LFGPTAAPPQ PATLLRLLDS EEGSAWPHLQ
410 420 430 440 450
QRKRLRRGRD NEQRPVPPAA EDVDSSDSDC EDEGDNLPAE HSSSAAGEGE
460 470 480 490 500
DEGDEADEAT LWGYQIGELL EEGGLGDGSE ASSIADHRDR AALLVSGLAV
510 520 530 540 550
MLPPALREAL HPLAARDRGD AQPWAELLLR AVPLNKLQQQ VLGQDLPSRP
560 570 580 590 600
AAAATAAVPL AAVVGVPLVT PAVQWVVRSL LALSTQRHPA DSGGDGVSVS
610 620 630 640 650
SGWSAMVFCQ RKVACVALHR LLTELPAARG GAIRPAVFMG NTGAGHSASS
660 670 680 690 700
LAMDGRKQER VRRAFSSGAL NVLISTSVGA EGLDFRTCNA VIMVDPPDHV
710 720 730 740 750
TPFVQCAGRA RAPGSCYLLF ARDDRQQQAI AKRSREEADM VAKALKLSTA
760 770 780 790 800
AAREAQQRQQ TDPPVNPFFS QDVDVVTEEL QQNLFRNLLE SYCRTLPGNS
810 820 830 840 850
GDVLLQPYYS YQEYESPLTR RKAFVATVHM PANSPLGVVE GPMQSNKGDA
860 870 880 890 900
RQHACMATVR RLYELGALDE HLLPRFTRRG RMREAQQQDL RGGGAATAAA
910 920 930 940 950
ATGRTRHRFG VVLHRRLPCD LPPFTAYLPP EDDSEAADGP QGQQPAPVAV
960 970 980 990 1000
RLEYLGPLRL SAAQLAALET AGGVMESLLI TRGAQPVATS SSATADKPVA
1010 1020 1030 1040 1050
APGPASAGPV PGSPALAAWS ERLGPGLAAL RRALAAAGIK TSAAYVHEAV
1060 1070 1080 1090 1100
NNVPDRMNST AGEPATAAQL PASGHWWWLV APLSEQTQAA SSQTAGTEAA
1110 1120 1130 1140 1150
AAGAVDWGFL ARLAAGPVPL QALCPQLPAL RPLAQQPAQG HQQQRQQLLP
1160 1170 1180 1190 1200
AAATGADVGS VGLHGHRQAA APGGQHVELL TAAVREALRG SGGLLITQTG
1210 1220 1230 1240 1250
ATLHALRGLT AVAEHDEAGT GSRKAAQDAA RLVERWGVDP SCLLPDQPQV
1260 1270 1280 1290 1300
LVDAGTATRT ASNVLLAPPQ PEHHPHSHHG AEDGSREAAA VISMLPQALA
1310 1320 1330 1340 1350
VAPLSVRCWR ALHRTVSLVH RLEGLLVAAE AEEELLRPAG FLRPAATAAA
1360 1370 1380 1390 1400
SGNPVLAIPV PTTAPSTSTA TTAAATPQQA AVLLALTALT ARAAADPAFD
1410 1420 1430 1440 1450
CERLETLGDA VLKYLATLYV YGTERDVPVS HEGVMSYKRD QLVANEALYG
1460 1470 1480 1490 1500
RALEAGLQHH MRALPYDMER VLRGRHWNTG EEAARAQEVR GKRLADCVEA
1510 1520 1530 1540 1550
LVGCHLAPGV PTAGSSSNSN DAQATSPGSA SAPVLVPVSA TNPVPGAPCQ
1560 1570 1580 1590 1600
DGSALAALVA ALRQTCAPAS GHTGVTDPSS NSGDVHARLD AALRFCCGLG
1610 1620 1630 1640 1650
VLPGAAPAVL QRLHAEGQGG AGEGAVQGVP DVGGEAGRAA VGALAAATGY
1660 1670 1680 1690 1700
QFHDPALALC ALTHVSWPVP PVSSSGKGLD AGAGSGGGSG GHYQLLEFLG
1710 1720 1730 1740 1750
DAVVGLLASL WAYSLGGSPR DMSMTREMLV RNDTLAACCL GSRLSTALRV
1760 1770 1780 1790 1800
RHRQLQLAIE EYGVALLMSY DTTSGRADAA ATGGGGPLIR AEMWKEAMAA
1810 1820 1830 1840 1850
RDLRVATLLQ SAWLEVEGGG TGEGVQAATD AAPGGGLHRG RRAYGLSGGD
1860 1870 1880 1890 1900
CDYRCTPMAA PPQLWRHGSI PHHTAQLSHV ARHVRPGSCM LAAGGSGHGG
1910 1920
NGAAVRGSWL RVRSANVPVA RVARVLA
Length:1,927
Mass (Da):201,859
Last modified:December 4, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62C8FDE391D30ADD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS496131 Genomic DNA Translation: EDP02111.1

NCBI Reference Sequences

More...
RefSeqi
XP_001694959.1, XM_001694907.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
PNW87565; PNW87565; CHLRE_02g141000v5

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5720424

Gramene; a comparative resource for plants

More...
Gramenei
PNW87565; PNW87565; CHLRE_02g141000v5

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cre:CHLREDRAFT_173928

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS496131 Genomic DNA Translation: EDP02111.1
RefSeqiXP_001694959.1, XM_001694907.1

3D structure databases

ProteinModelPortaliA8J0M8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3055.EDP02111

Proteomic databases

PaxDbiA8J0M8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiPNW87565; PNW87565; CHLRE_02g141000v5
GeneIDi5720424
GrameneiPNW87565; PNW87565; CHLRE_02g141000v5
KEGGicre:CHLREDRAFT_173928

Phylogenomic databases

eggNOGiKOG0701 Eukaryota
COG1111 LUCA
InParanoidiA8J0M8
KOiK11592
OrthoDBi1337630at2759

Family and domain databases

CDDicd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 2 hits
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF00636 Ribonuclease_3, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8J0M8_CHLRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8J0M8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: April 10, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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