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Protein

4-hydroxy-tetrahydrodipicolinate synthase

Gene

DPS1

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Pyruvate + L-aspartate-4-semialdehyde = (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate + H2O.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 3 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Uncharacterized protein (CHLRE_10g458500v5), Aspartokinase (ASK1)
  2. no protein annotated in this organism
  3. 4-hydroxy-tetrahydrodipicolinate synthase (DPS1), 4-hydroxy-tetrahydrodipicolinate synthase (CHLRE_02g107300v5)
  4. no protein annotated in this organism
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00034; UER00017

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-tetrahydrodipicolinate synthaseUniRule annotation (EC:4.3.3.7UniRule annotation)
Short name:
HTPA synthaseUniRule annotation
Gene namesi
Name:DPS1Imported
Synonyms:dapAImported
ORF Names:CHLREDRAFT_126518Imported
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

PTM / Processingi

Proteomic databases

PaxDbiA8I3W3
ProMEXiA8I3W3

Interactioni

Protein-protein interaction databases

STRINGi3055.EDP07434

Structurei

3D structure databases

ProteinModelPortaliA8I3W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IJ4Q Eukaryota
COG0329 LUCA
InParanoidiA8I3W3
KOiK01714

Family and domain databases

CDDicd00950 DHDPS, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00418 DapA, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR005263 DapA
IPR002220 DapA-like
IPR020625 Schiff_base-form_aldolases_AS
IPR020624 Schiff_base-form_aldolases_CS
PANTHERiPTHR12128 PTHR12128, 1 hit
PfamiView protein in Pfam
PF00701 DHDPS, 1 hit
PIRSFiPIRSF001365 DHDPS, 1 hit
PRINTSiPR00146 DHPICSNTHASE
SMARTiView protein in SMART
SM01130 DHDPS, 1 hit
TIGRFAMsiTIGR00674 dapA, 1 hit
PROSITEiView protein in PROSITE
PS00665 DHDPS_1, 1 hit
PS00666 DHDPS_2, 1 hit

Sequencei

Sequence statusi: Complete.

A8I3W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFSRTRAP TCPGARRARP SAVRVQATLL PLPASETRST VDRLKKLRLI
60 70 80 90 100
TAIKTPYLAN GKFDLPAYDA LVSHQIENGV EGLIVGGTTG EGHLMSWDEH
110 120 130 140 150
VMLIAHTVNA FGDKTAVIGN TGSNSTREAL HATEQGFAVG MHASLQINPY
160 170 180 190 200
YGKTSKAGLL NHFNAVLNEG PAVVYNVPGR TGQDIPDDVV MEICQHSNFL
210 220 230 240 250
GMKECTGNSR IKNYTSKGVN CWSGNDDESH DARHSNGAVG VISVTSNVIP
260 270 280 290 300
GLMHKLMHGS PDPQLNADLK ELMAWMFCEP NPISLNTALA MCGLARPVFR
310 320 330 340
LPYVPLSRAQ REKGAVLLNK VQEHIPGCKS VRVMEDHEFI LVGRH
Length:345
Mass (Da):37,477
Last modified:December 4, 2007 - v1
Checksum:i6BA34507BB91A208
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS496112 Genomic DNA Translation: EDP07434.1
RefSeqiXP_001699738.1, XM_001699686.1
UniGeneiCre.2995

Genome annotation databases

EnsemblPlantsiEDP07434; EDP07434; CHLREDRAFT_126518
GeneIDi5725512
GrameneiEDP07434; EDP07434; CHLREDRAFT_126518
KEGGicre:CHLREDRAFT_126518

Similar proteinsi

Entry informationi

Entry nameiA8I3W3_CHLRE
AccessioniPrimary (citable) accession number: A8I3W3
Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 18, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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