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Protein

Cbb3-type cytochrome c oxidase subunit FixP

Gene

fixP

Organism
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. FixP subunit is required for transferring electrons from donor cytochrome c via its heme groups to FixO subunit. From there, electrons are shuttled to the catalytic binuclear center of FixN subunit where oxygen reduction takes place. The complex also functions as a proton pump (By similarity).By similarity

Cofactori

heme cBy similarity1 PublicationNote: Binds 2 heme C groups per subunit.By similarity1 Publication

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127Heme C 1 (covalent)By similarity1
Binding sitei130Heme C 1 (covalent)By similarity1
Metal bindingi131Iron (heme C 1 axial ligand)By similarity1
Metal bindingi178Iron (heme C 2 axial ligand)By similarity1
Binding sitei222Heme C 2 (covalent)By similarity1
Binding sitei225Heme C 2 (covalent)By similarity1
Metal bindingi226Iron (heme C 2 axial ligand)By similarity1
Metal bindingi267Iron (heme C 1 axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciACAU438753:G1G2W-4697-MONOMER
UniPathwayi
UPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cbb3-type cytochrome c oxidase subunit FixPBy similarityImported
Short name:
Cbb3-Cox subunit FixPBy similarity
Alternative name(s):
C-type cytochrome FixPBy similarity
Short name:
Cyt c(FixP)By similarity
Cytochrome c oxidase subunit IIIBy similarity
Gene namesi
Name:fixPImported
Ordered Locus Names:AZC_4526
OrganismiAzorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)
Taxonomic identifieri438753 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesXanthobacteraceaeAzorhizobium
Proteomesi
  • UP000000270 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004122951 – 293Cbb3-type cytochrome c oxidase subunit FixPAdd BLAST293

Interactioni

Subunit structurei

Component of the cbb3-type cytochrome c oxidase at least composed of FixN, FixO, FixQ and FixP.By similarity

Protein-protein interaction databases

STRINGi438753.AZC_4526

Structurei

3D structure databases

ProteinModelPortaliA8HZ17
SMRiA8HZ17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 201Cytochrome c 1PROSITE-ProRule annotationAdd BLAST88
Domaini209 – 290Cytochrome c 2PROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Belongs to the CcoP / FixP family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D6P Bacteria
COG2010 LUCA
HOGENOMiHOG000277941
KOiK00406
OMAiTDNDWLY
OrthoDBiPOG091H05TP

Family and domain databases

Gene3Di1.10.760.10, 2 hits
1.20.58.1490, 1 hit
InterProiView protein in InterPro
IPR032858 CcoP_N
IPR038414 CcoP_N_sf
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR008168 Cyt_C_IC
IPR004678 Cyt_c_oxidase_cbb3_su3
PfamiView protein in Pfam
PF13442 Cytochrome_CBB3, 2 hits
PF14715 FixP_N, 1 hit
PIRSFiPIRSF000006 Cbb3-Cox_fixP, 1 hit
PRINTSiPR00605 CYTCHROMECIC
SUPFAMiSSF46626 SSF46626, 2 hits
TIGRFAMsiTIGR00782 ccoP, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 2 hits

Sequencei

Sequence statusi: Complete.

A8HZ17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTSHESHHA PVDGAGGPST TGHEWDGIQE LNNPLPRWWL WTFYATIIWA
60 70 80 90 100
FGYWVAYPAW PLVSNYTSGV LGWNSRSAVV EQISDLQKLR AASSAKLANV
110 120 130 140 150
PLEDIEKNPE LLSLARAEGK VAFADNCAPC HGAGGGGAKG FPNLNDDDWL
160 170 180 190 200
WGGTLAQIQQ TITHGIRSGD DEGHQGNMLA FGSILSKADI SNVADYVRSL
210 220 230 240 250
SGAAPGDTPA AKKGAEIFAA NCATCHGENG KGNQELGSKN LTDGIWLYGG
260 270 280 290
DKATIVQTIT NGRGGVMPAW GPRLSPTTIK ALTVYVHTLG GGQ
Length:293
Mass (Da):30,980
Last modified:December 4, 2007 - v1
Checksum:i8306973270FDEDEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74410 Genomic DNA Translation: CAA52432.1
AP009384 Genomic DNA Translation: BAF90524.1
PIRiD55582
RefSeqiWP_012173045.1, NC_009937.1

Genome annotation databases

EnsemblBacteriaiBAF90524; BAF90524; AZC_4526
KEGGiazc:AZC_4526

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74410 Genomic DNA Translation: CAA52432.1
AP009384 Genomic DNA Translation: BAF90524.1
PIRiD55582
RefSeqiWP_012173045.1, NC_009937.1

3D structure databases

ProteinModelPortaliA8HZ17
SMRiA8HZ17
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi438753.AZC_4526

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF90524; BAF90524; AZC_4526
KEGGiazc:AZC_4526

Phylogenomic databases

eggNOGiENOG4105D6P Bacteria
COG2010 LUCA
HOGENOMiHOG000277941
KOiK00406
OMAiTDNDWLY
OrthoDBiPOG091H05TP

Enzyme and pathway databases

UniPathwayi
UPA00705

BioCyciACAU438753:G1G2W-4697-MONOMER

Family and domain databases

Gene3Di1.10.760.10, 2 hits
1.20.58.1490, 1 hit
InterProiView protein in InterPro
IPR032858 CcoP_N
IPR038414 CcoP_N_sf
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR008168 Cyt_C_IC
IPR004678 Cyt_c_oxidase_cbb3_su3
PfamiView protein in Pfam
PF13442 Cytochrome_CBB3, 2 hits
PF14715 FixP_N, 1 hit
PIRSFiPIRSF000006 Cbb3-Cox_fixP, 1 hit
PRINTSiPR00605 CYTCHROMECIC
SUPFAMiSSF46626 SSF46626, 2 hits
TIGRFAMsiTIGR00782 ccoP, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFIXP_AZOC5
AccessioniPrimary (citable) accession number: A8HZ17
Secondary accession number(s): Q43945
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: December 4, 2007
Last modified: November 7, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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