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Protein

Acetate kinase

Gene

ackA

Organism
Rickettsia akari (strain Hartford)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumUniRule annotation1
Binding sitei16ATPUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Active sitei144Proton donor/acceptorUniRule annotation1
Sitei175Transition state stabilizerUniRule annotation1
Sitei235Transition state stabilizerUniRule annotation1
Metal bindingi373MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 206ATPUniRule annotation5
Nucleotide bindingi277 – 279ATPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRAKA293614:G1GA4-151-MONOMER
UniPathwayiUPA00340; UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:A1C_00830
OrganismiRickettsia akari (strain Hartford)
Taxonomic identifieri293614 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000006830 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000022501 – 385Acetate kinaseAdd BLAST385

Proteomic databases

PRIDEiA8GM71

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi293614.A1C_00830

Structurei

3D structure databases

ProteinModelPortaliA8GM71
SMRiA8GM71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
HOGENOMiHOG000288399
KOiK00925
OMAiFMMQKEN
OrthoDBiPOG091H02K4

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A8GM71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDVILIANA GSSSLKISIF EIQNKQVKDK IYNIFLEKND NKILCYINKK
60 70 80 90 100
QESATDIKDD AIEMMIDLFE DWWKKQENLN LIATGHRIVH GGKNFNKPVI
110 120 130 140 150
VNEKVSEDLR VLIPLNPLHQ PYNLQVLDLF LQKYKEIVHI ACFDTSFHFT
160 170 180 190 200
NPPITKAFGL PKKYYAKGII RYGFHGLSYK YVSSHFKEMT KEDLPIKTII
210 220 230 240 250
AHLGSGSSLC AIKNGLSLTS SMGFSVLDGV MMGTRTGNID PGIVLYLIDH
260 270 280 290 300
EKMTTKEITE LLYKKSGLLG ISGESSDIRT LLASNSPDAK FAIDLFVYRI
310 320 330 340 350
VLEIGKLTAA LEGIDGLIFT AGVGQNSAVI REMISAKLSW LGIKIDDTKN
360 370 380
QKNEHLISTE SSKVKVFAVP TNEELIIAEE VIKFL
Length:385
Mass (Da):43,118
Last modified:November 13, 2007 - v1
Checksum:i8A41C51E368DC2A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000847 Genomic DNA Translation: ABV74496.1
RefSeqiWP_012013366.1, NC_009881.1

Genome annotation databases

EnsemblBacteriaiABV74496; ABV74496; A1C_00830
KEGGirak:A1C_00830

Similar proteinsi

Entry informationi

Entry nameiACKA_RICAH
AccessioniPrimary (citable) accession number: A8GM71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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