UniProtKB - A8GBX8 (BETB_SERP5)
Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB
Organism
Serratia proteamaculans (strain 568)
Status
Functioni
Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation
Catalytic activityi
- EC:1.2.1.8UniRule annotation
Cofactori
K+UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation
: betaine biosynthesis via choline pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.UniRule annotationProteins known to be involved in this subpathway in this organism are:
- NAD/NADP-dependent betaine aldehyde dehydrogenase (betB)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 93 | Potassium 1UniRule annotation | 1 | |
Active sitei | 162 | Charge relay systemUniRule annotation | 1 | |
Metal bindingi | 180 | Potassium 1; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 209 | NAD/NADP; via amide nitrogenUniRule annotation | 1 | |
Metal bindingi | 246 | Potassium 2; via carbonyl oxygenUniRule annotation | 1 | |
Sitei | 248 | Seems to be a necessary countercharge to the potassium cationsUniRule annotation | 1 | |
Active sitei | 252 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 286 | NAD/NADPUniRule annotation | 1 | |
Binding sitei | 387 | NAD/NADPUniRule annotation | 1 | |
Metal bindingi | 457 | Potassium 2; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 460 | Potassium 2; via carbonyl oxygenUniRule annotation | 1 | |
Active sitei | 464 | Charge relay systemUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 150 – 153 | NAD/NADPUniRule annotation | 4 | |
Nucleotide bindingi | 176 – 179 | NAD/NADPUniRule annotation | 4 | |
Nucleotide bindingi | 229 – 234 | NAD/NADPUniRule annotation | 6 |
GO - Molecular functioni
- betaine-aldehyde dehydrogenase activity Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- glycine betaine biosynthetic process from choline Source: UniProtKB-UniRule
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD, NADP, Potassium |
Enzyme and pathway databases
UniPathwayi | UPA00529;UER00386 |
Names & Taxonomyi
Protein namesi | Recommended name: NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)Short name: BADHUniRule annotation |
Gene namesi | Name:betBUniRule annotation Ordered Locus Names:Spro_1514 |
Organismi | Serratia proteamaculans (strain 568) |
Taxonomic identifieri | 399741 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Yersiniaceae › Serratia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000062270 | 1 – 490 | NAD/NADP-dependent betaine aldehyde dehydrogenaseAdd BLAST | 490 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 286 | Cysteine sulfenic acid (-SOH)UniRule annotation | 1 |
Keywords - PTMi
OxidationInteractioni
Subunit structurei
Dimer of dimers.
UniRule annotationProtein-protein interaction databases
STRINGi | 399741.Spro_1514 |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG1012, Bacteria |
HOGENOMi | CLU_005391_0_1_6 |
OMAi | IMRERNR |
OrthoDBi | 744602at2 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
HAMAPi | MF_00804, BADH, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR011264, BADH |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR01804, BADH, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
i Sequence
Sequence statusi: Complete.
A8GBX8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRFGLQKLY INGAYVDSTD GKTFNAVNPA NGEVLAEIQS ASAEDVNRAV
60 70 80 90 100
ASAASGQKVW AAMTAMARSR ILRRAVDILR ERNDELAALE TLDTGKAMSE
110 120 130 140 150
TTAVDIVTGA DVLEYYAGLI PSIEGQQIPL RDTSFVYTRR EPLGVVAGIG
160 170 180 190 200
AWNYPIQIAL WKSAPALAAG NAMIFKPSEV TSLTALKLAE IYTEAGLPDG
210 220 230 240 250
VFNVVTGSGA EVGQYLTDHP GIAKVSFTGG VKTGKKVMAN ASGSTLKEVT
260 270 280 290 300
MELGGKSPLI IFDDADLDRA ADIAMMANFY SSGQVCTNGT RVFVPAALQA
310 320 330 340 350
QFEAKILERV KRIRLGDPTD PQTNFGPLVS FAHMESVLRF IESGKNSGAR
360 370 380 390 400
LLCGGERVTE GEFAKGAYVA PTVFTDCRDE MEIVREEIFG PVMSILSYQS
410 420 430 440 450
EEEVVRRAND TTFGLAAGVV TNDLTRAHRV IHQLEAGICW INTWGESAAE
460 470 480 490
MPVGGYKQSG VGRENGLMTL EHYTQIKSVQ VELGEYASVF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000826 Genomic DNA Translation: ABV40618.1 |
RefSeqi | WP_012005947.1, NC_009832.1 |
Genome annotation databases
EnsemblBacteriai | ABV40618; ABV40618; Spro_1514 |
KEGGi | spe:Spro_1514 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000826 Genomic DNA Translation: ABV40618.1 |
RefSeqi | WP_012005947.1, NC_009832.1 |
3D structure databases
SMRi | A8GBX8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 399741.Spro_1514 |
Genome annotation databases
EnsemblBacteriai | ABV40618; ABV40618; Spro_1514 |
KEGGi | spe:Spro_1514 |
Phylogenomic databases
eggNOGi | COG1012, Bacteria |
HOGENOMi | CLU_005391_0_1_6 |
OMAi | IMRERNR |
OrthoDBi | 744602at2 |
Enzyme and pathway databases
UniPathwayi | UPA00529;UER00386 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
HAMAPi | MF_00804, BADH, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR011264, BADH |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR01804, BADH, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BETB_SERP5 | |
Accessioni | A8GBX8Primary (citable) accession number: A8GBX8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | November 13, 2007 | |
Last modified: | December 2, 2020 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families