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Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6MagnesiumUniRule annotation1
Metal bindingi51MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciCJEJ407148:G1G9V-1364-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:acpSUniRule annotation
Ordered Locus Names:C8J_1323
OrganismiCampylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)
Taxonomic identifieri407148 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000712951 – 115Holo-[acyl-carrier-protein] synthaseAdd BLAST115

Structurei

3D structure databases

ProteinModelPortaliA8FN84
SMRiA8FN84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000014315
KOiK00997
OMAiSHDAGFA

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00516 acpS, 1 hit
TIGR00556 pantethn_trn, 1 hit

Sequencei

Sequence statusi: Complete.

A8FN84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVGCDIIAI SRIEKIHSRH GKNFLDKFLS PKEQILIKNP ATLAGLWAAK
60 70 80 90 100
EAASKALGVG ICELCSFFDI EISKDEKNAP KLKYSQKITK NFNITQTSLS
110
ISHDNGFAIA IVAIV
Length:115
Mass (Da):12,644
Last modified:November 13, 2007 - v1
Checksum:iFFB0AAE8B63D56D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000814 Genomic DNA Translation: ABV52921.1
RefSeqiWP_002866684.1, NC_009839.1

Genome annotation databases

EnsemblBacteriaiABV52921; ABV52921; C8J_1323
KEGGicju:C8J_1323

Similar proteinsi

Entry informationi

Entry nameiACPS_CAMJ8
AccessioniPrimary (citable) accession number: A8FN84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 13, 2007
Last modified: February 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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