Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Malate dehydrogenase

Gene

mdh

Organism
Arcobacter butzleri (strain RM4018)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei84SubstrateBy similarity1
Binding sitei90SubstrateBy similarity1
Binding sitei97NADBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei153SubstrateBy similarity1
Active sitei177Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 15NADBy similarity7
Nucleotide bindingi120 – 122NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciABUT367737:G1G6I-1314-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseBy similarity (EC:1.1.1.37By similarity)
Gene namesi
Name:mdhBy similarity
Ordered Locus Names:Abu_1315
OrganismiArcobacter butzleri (strain RM4018)
Taxonomic identifieri367737 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
Proteomesi
  • UP000001136 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001916391 – 314Malate dehydrogenaseAdd BLAST314

Proteomic databases

PRIDEiA8EUE8

Interactioni

Protein-protein interaction databases

STRINGi367737.Abu_1315

Structurei

3D structure databases

ProteinModelPortaliA8EUE8
SMRiA8EUE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiMDLMQTA
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit

Sequencei

Sequence statusi: Complete.

A8EUE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNKTIGIIG VGNVGSTLAF ILATNNICSN ILLKDIKNNI SEAMALDISQ
60 70 80 90 100
AMQETNSNTK ITACLNNEDF KDCDIIIITA GIARKPNMSR DDLLITNAKI
110 120 130 140 150
VASVMNDISK NNPNAIIIII SNPLDSMVYT ALKSSNYPKN KILGMAGTLD
160 170 180 190 200
SARMSYFIAE KLGFPNVNIK TSVIGGHGDS MVPLIDFSTV DGKKLNEVLS
210 220 230 240 250
KEDIDDIVIK TKNGGGQIVK LLETGSAYYA PAYSTIAMIE AILNDTKKCF
260 270 280 290 300
ACATILNGEY GYKDIVSGVP VILGKDGVEK IIELEISDFE KEQFSNSINS
310
VKESINILEN NFFN
Length:314
Mass (Da):33,995
Last modified:November 13, 2007 - v1
Checksum:i96424DBB8906CDA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000361 Genomic DNA Translation: ABV67572.1
RefSeqiWP_012012982.1, NC_009850.1

Genome annotation databases

EnsemblBacteriaiABV67572; ABV67572; Abu_1315
GeneIDi24303636
KEGGiabu:Abu_1315

Similar proteinsi

Entry informationi

Entry nameiMDH_ARCB4
AccessioniPrimary (citable) accession number: A8EUE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health