UniProtKB - A8E7F4 (A8E7F4_DANRE)
Protein
Submitted name:
MHC class I antigen ZBA transcript variant 1
Gene
mhc1zba
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Enzyme and pathway databases
Reactomei | R-DRE-1236974, ER-Phagosome pathway R-DRE-1236977, Endosomal/Vacuolar pathway R-DRE-6798695, Neutrophil degranulation R-DRE-917977, Transferrin endocytosis and recycling R-DRE-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Names & Taxonomyi
Protein namesi | Submitted name: MHC class I antigen ZBA transcript variant 1ImportedSubmitted name: Major histocompatibility complex class I ZBAImportedSubmitted name: Zgc:64115 proteinImported |
Gene namesi | ORF Names:zgc:64115Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040426-2149, mhc1zba |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: GO_Central
Plasma Membrane
- external side of plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 317 – 341 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5015086638 | 22 – 398 | Sequence analysisAdd BLAST | 377 |
Keywords - PTMi
GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000036588, Expressed in pharyngeal gill and 30 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 211 – 300 | Ig-likeInterPro annotationAdd BLAST | 90 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 350 – 398 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 372 – 398 | PolarSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the MHC class I family.UniRule annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG502QU05, Eukaryota |
GeneTreei | ENSGT01020000230536 |
OrthoDBi | 912212at2759 |
TreeFami | TF334519 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
A8E7F4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSFAVLFSA VMLVAVVPAW TEKHSLYYIY TALSRPVNLP GIYEFTAMGL
60 70 80 90 100
LDDRQIDYYN SEQQKKIPKQ HWMKEKMQED YWEKGTQSRK SKEQWFNVNV
110 120 130 140 150
NILMERMRHN KSDVHVLQWR HGCEIESQGN DVRFSRGIDE YSYDGRNFLS
160 170 180 190 200
FDDAESQWVA PVEEALPTKR KWDNVPILNQ YTKGYLEKEC VDWLNKFREY
210 220 230 240 250
GDKELREGSS PEVHVFAKRI INGKIKLKLT CLATGFYPKD VILNIRKYRI
260 270 280 290 300
TLPDNEVEST GVRPNEDGTF QLRKSINIYE DEKAEYDCYV SHTTLKEPII
310 320 330 340 350
KKWDGECLDG PESGSPIGII AGAIIVVLVV LAAIGGAVYF LRKRSGNNNV
360 370 380 390
KPSSVPTISG NKDEKCSMLP GSDDSGQGSS DGSSKSSPTN SQEKMDIV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005416 Genomic DNA No translation available. BC154330 mRNA Translation: AAI54331.1 KC607831 mRNA Translation: AHA37371.1 |
RefSeqi | NP_001103588.1, NM_001110118.1 |
Genome annotation databases
Ensembli | ENSDART00000053153; ENSDARP00000053152; ENSDARG00000036588 |
GeneIDi | 791453 |
KEGGi | dre:791453 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005416 Genomic DNA No translation available. BC154330 mRNA Translation: AAI54331.1 KC607831 mRNA Translation: AHA37371.1 |
RefSeqi | NP_001103588.1, NM_001110118.1 |
3D structure databases
SMRi | A8E7F4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000053152 |
Genome annotation databases
Ensembli | ENSDART00000053153; ENSDARP00000053152; ENSDARG00000036588 |
GeneIDi | 791453 |
KEGGi | dre:791453 |
Organism-specific databases
CTDi | 791453 |
ZFINi | ZDB-GENE-040426-2149, mhc1zba |
Phylogenomic databases
eggNOGi | ENOG502QU05, Eukaryota |
GeneTreei | ENSGT01020000230536 |
OrthoDBi | 912212at2759 |
TreeFami | TF334519 |
Enzyme and pathway databases
Reactomei | R-DRE-1236974, ER-Phagosome pathway R-DRE-1236977, Endosomal/Vacuolar pathway R-DRE-6798695, Neutrophil degranulation R-DRE-917977, Transferrin endocytosis and recycling R-DRE-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Gene expression databases
Bgeei | ENSDARG00000036588, Expressed in pharyngeal gill and 30 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8E7F4_DANRE | |
Accessioni | A8E7F4Primary (citable) accession number: A8E7F4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 13, 2007 |
Last sequence update: | November 13, 2007 | |
Last modified: | April 7, 2021 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |