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UniProtKB - A8E6E2 (A8E6E2_DANRE)
Protein
Submitted name:
Interferon phi 2
Gene
ifnphi2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- cytokine receptor binding Source: InterPro
GO - Biological processi
- defense response to virus Source: ZFIN
Keywordsi
Molecular function | CytokineUniRule annotation |
Biological process | Antiviral defenseUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Interferon phi 2Submitted name: Type I interferon 2Imported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-071128-1, ifnphi2 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5015086629 | 22 – 181 | Sequence analysisAdd BLAST | 160 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 ↔ 121 | Combined sources | ||
Disulfide bondi | 51 ↔ 160 | Combined sources |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000069012, Expressed in intestine and 8 other tissues |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- cytokine receptor binding Source: InterPro
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000058506 |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the alpha/beta interferon family.UniRule annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | ENOG502SQAC, Eukaryota |
GeneTreei | ENSGT01000000214430 |
OMAi | CCLQMML |
OrthoDBi | 1358010at2759 |
Family and domain databases
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000471, Interferon_alpha/beta/delta |
PANTHERi | PTHR11691, PTHR11691, 1 hit |
Pfami | View protein in Pfam PF00143, Interferon, 1 hit |
PRINTSi | PR00266, INTERFERONAB |
SMARTi | View protein in SMART SM00076, IFabd, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A8E6E2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEFWQFVAFL CPALFFAHIT SKPTNCFMRR KHVKTAYSLL ESMGGLFPRE
60 70 80 90 100
CLKENVRITF PKYALQSNNS NQKTGVAKAV YKIMDHIDFL FANDSYPEAW
110 120 130 140 150
NKRKVDNFQN IVYRLTKENQ CIMRMRAQGT VDDFPARDDA LKSYFNKLAT
160 170 180
LLRNKDNSFC AWEVVRHELL GVLSDIIQPK L
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4ICL1 | A0A0R4ICL1_DANRE | Interferon phi 2 | ifnphi2 | 184 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005440 Genomic DNA No translation available. BN001102 Genomic DNA Translation: CAM33456.1 |
RefSeqi | NP_001104552.1, NM_001111082.1 |
Genome annotation databases
Ensembli | ENSDART00000058507.7; ENSDARP00000058506.6; ENSDARG00000069012.6 |
GeneIDi | 100126802 |
KEGGi | dre:100126802 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005440 Genomic DNA No translation available. BN001102 Genomic DNA Translation: CAM33456.1 |
RefSeqi | NP_001104552.1, NM_001111082.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3PIW | X-ray | 1.49 | A | 22-181 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000058506 |
Genome annotation databases
Ensembli | ENSDART00000058507.7; ENSDARP00000058506.6; ENSDARG00000069012.6 |
GeneIDi | 100126802 |
KEGGi | dre:100126802 |
Organism-specific databases
CTDi | 100126802 |
ZFINi | ZDB-GENE-071128-1, ifnphi2 |
Phylogenomic databases
eggNOGi | ENOG502SQAC, Eukaryota |
GeneTreei | ENSGT01000000214430 |
OMAi | CCLQMML |
OrthoDBi | 1358010at2759 |
Gene expression databases
Bgeei | ENSDARG00000069012, Expressed in intestine and 8 other tissues |
Family and domain databases
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000471, Interferon_alpha/beta/delta |
PANTHERi | PTHR11691, PTHR11691, 1 hit |
Pfami | View protein in Pfam PF00143, Interferon, 1 hit |
PRINTSi | PR00266, INTERFERONAB |
SMARTi | View protein in SMART SM00076, IFabd, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A8E6E2_DANRE | |
Accessioni | A8E6E2Primary (citable) accession number: A8E6E2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 13, 2007 |
Last sequence update: | November 13, 2007 | |
Last modified: | May 25, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |