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Entry version 43 (07 Apr 2021)
Sequence version 1 (13 Nov 2007)
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Protein

Large tegument protein deneddylase

Gene

M48

Organism
Murid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei10Important for catalytic activityUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei23UniRule annotation1
Active sitei156UniRule annotation1
Active sitei158UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processHost-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Large tegument protein deneddylaseUniRule annotation (EC:3.4.19.12UniRule annotation, EC:3.4.22.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:M48
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMurid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri69156 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraePeploviricotaHerviviricetesHerpesviralesHerpesviridaeBetaherpesvirinaeMuromegalovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiMus musculus (Mouse) [TaxID: 10090]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000158680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003969541 – 2147Large tegument protein deneddylaseAdd BLAST2147

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A8E1C4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins.

Interacts with inner tegument protein.

Interacts with capsid vertex specific component CVC2.

Interacts with the major capsid protein/MCP.

UniRule annotation

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A8E1C4, 29 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8E1C4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 223Peptidase C76UniRule annotationAdd BLAST221

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 233Deubiquitination activityUniRule annotationAdd BLAST233
Regioni292Interaction with inner tegument proteinUniRule annotation1

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi233 – 238Poly-Gly6
Compositional biasi465 – 468Poly-Thr4
Compositional biasi536 – 539Poly-Ala4
Compositional biasi687 – 690Poly-Ser4
Compositional biasi691 – 694Poly-Pro4
Compositional biasi1567 – 1570Poly-Ser4
Compositional biasi2046 – 2049Poly-Ser4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae large tegument protein family.UniRule annotation

Keywords - Domaini

Repeat

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_04044, HSV_LTP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006928, Herpes_teg_USP
IPR034702, HSV_LTP
IPR038765, Papain-like_cys_pep_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04843, Herpes_teg_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51521, HTUSP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8E1C4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIVRASRDQ SAPVYGPRAG SQCMSNCFTF LHTCYLMGID PVLDTTSLDA
60 70 80 90 100
VLDSGARLDA IADEKVKRQA LTDHPYRLGT EIPTVIETPA GITGHALSRP
110 120 130 140 150
FNGTAETQDL GGYKCLGILD FLTYARGKPL PVYIIVTVGV HTRGVIVARG
160 170 180 190 200
ATYVFDPHTT DLSAEAAVYV CDDFTEAISA LSFFGAMIGD FYYDAVLVYF
210 220 230 240 250
TRCRTTLISP SELLVQIMDQ YKDPDIDASV MSGSGGGGPS ISSSAASASA
260 270 280 290 300
SVSPLPSGAA SDGVTNGAGA QTSSKSGKKR RAPDVPPQQK GTAKTLRRSR
310 320 330 340 350
RPIRLPERLS EVIVEDVQTI EHFRTATQSL PVKPPQEWTM YCGEEPFYRQ
360 370 380 390 400
YFVDVGRQLL AHAIDTYVSL DKTTDESAVQ RFESLMGLSD ELDAVIAAAR
410 420 430 440 450
ATELSAPPLY KTYLSQRVSA SAVTRTDRLL ASKILALFEE GSATDFETVS
460 470 480 490 500
SWLRELLQQL PVENTTTTEA KIAAFVAQHP IPGERAFVCL RNSQVKSLGE
510 520 530 540 550
LLSVKRETLK VKYMENDATY RKILDAISKL GLASNAAAAI QSADTSHLDS
560 570 580 590 600
EQLASLAQAA EAYAQSAYES CQAKMTELLS TNHNRILTGS LPDSDIAAVL
610 620 630 640 650
AAFKAVSENV RALREVELLK SQVHVQLAQL TEDLLYLQTA EVKLEVTPSA
660 670 680 690 700
EIKKLRAEYE TARKQISDEE MRIKELIENM EDMITDSSSS PPPPEMLDML
710 720 730 740 750
RTQIEEVESM TVDEQDARRA DKVLGKLSTL DEAEAKATEF AQSLSTVNIP
760 770 780 790 800
SLNEIKGVKM LKSVLETNAD LRRAYVQAVT GMLENALKQL AEGNLPSDDM
810 820 830 840 850
MSRITALAEQ LPTGRQVRAD LLDSTDIVSQ MSRRLRYAAN QKNSTQSLED
860 870 880 890 900
VLNFFSENDD MIRKLLKTSW GKPVATVYRR VQVEYDRKME ELRESEWLKR
910 920 930 940 950
VKETDIDSPQ TLERLLKTAP NETILAKHAP DMHARLKKRM QSEAEKRTAD
960 970 980 990 1000
MKRLYEEMRK KVDTDLKVVS DSFSSQTPSM FSSIDLKSCG TSLVRLTKED
1010 1020 1030 1040 1050
RKAAIATFNA NLTKSLNSLL ASLVTVETAT IAAILKGADP EATSSTGSAG
1060 1070 1080 1090 1100
GGADRQKHTS TLENNISTLL GWQQKVLLPE TERDLLTIAH LLTALTHMRK
1110 1120 1130 1140 1150
NWRNPAAAFS STPHTAAYRN FAELANEIES RRTETLARYK SKYAELNASI
1160 1170 1180 1190 1200
HDNTKANDVT IKPEDTFTAA FRDTVKAMAA PFSTELQARL QARENELKDE
1210 1220 1230 1240 1250
LSDLNVKLKT KLERYLAKRS SQDARWRDLI TQHRIRLPEG LDVDTNRLRT
1260 1270 1280 1290 1300
DTVVTLNGII RSAATTLPYI TAKRGLEWTT EFILAAIEEK KDADPGMFAQ
1310 1320 1330 1340 1350
LATLLDNSQA IARKIEEKIV YNTKVEAEML ETAPEHTRES LSNLQLMLGQ
1360 1370 1380 1390 1400
LEAKRVVGGE ARYKILSDAI LTKQNKLAFA EDLEKLSARY FELARDIRSS
1410 1420 1430 1440 1450
KYGLDFDAQL LKTSLLKSEI GQHKKDPPST GEEVGLPEES TTAAKISISS
1460 1470 1480 1490 1500
LLLGIAALEK YIVAHRTLLD NFVSSQPLIS QAENIPALVG GPGEDDKPGQ
1510 1520 1530 1540 1550
EPFDWTRIDL SRLSACDVST ALYRGTDVFG ERRVMTARGI QLYLYATHGN
1560 1570 1580 1590 1600
FVFEAFSHVR GTKGLLSSSS GGGNGSGASS RQKDQQNATV TRRYRSVTVL
1610 1620 1630 1640 1650
ASIAATLQTF WSEISRYDIR ELLVESGRDP ESAADQRDRR LNTVMNLKLF
1660 1670 1680 1690 1700
VYVMTVAWSE ATPPVEPGSP EATHALEVSL LDFSTLMAAL HPEYVYAITT
1710 1720 1730 1740 1750
QPVDATLRGL IARLDRRTVD AAMNTQENPP PYDMRELKAF CLDTKQWTQE
1760 1770 1780 1790 1800
DIRPQMWMSD LVKQICTSHP RNRDASTSTK LFLYMLATKV LPRDILRCLW
1810 1820 1830 1840 1850
VQFRPAYASS IASLEELVSA LCDSFFKIYG TTSETVSARL KTGEKVERQV
1860 1870 1880 1890 1900
VLRHKPTMSL LDEFSQQEAV LDYILGSYVF AIPMTVGIHV TNIVNGRYRL
1910 1920 1930 1940 1950
IVRHLENLPS DPDFVKVVRS RDLSFDRFGW SYTVQNPVER SWFSLQEDRL
1960 1970 1980 1990 2000
RHLLTNPPQQ DRTPLVVYDS NTNYAVNAMM PPLKAPPATS RVHLTVKNPF
2010 2020 2030 2040 2050
STMRMIPHED EGDDAATSET PFTSLPINID FLRRDPPRLK RASGDSSSSV
2060 2070 2080 2090 2100
PAEDRDPDAR PQDSVPDQSL SEPLFSQTKV SSIVPKDAVT TLSNESISQT
2110 2120 2130 2140
FQIHPFRALS SAIMAAIEIL QETRLQLDTF ESDMCEAIRR IKILYLH
Length:2,147
Mass (Da):238,457
Last modified:November 13, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C5DB3F99EF1A63A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AM886412 Genomic DNA Translation: CAP08095.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM886412 Genomic DNA Translation: CAP08095.1

3D structure databases

SMRiA8E1C4
ModBaseiSearch...

Protein-protein interaction databases

IntActiA8E1C4, 29 interactors

Proteomic databases

PRIDEiA8E1C4

Family and domain databases

HAMAPiMF_04044, HSV_LTP, 1 hit
InterProiView protein in InterPro
IPR006928, Herpes_teg_USP
IPR034702, HSV_LTP
IPR038765, Papain-like_cys_pep_sf
PfamiView protein in Pfam
PF04843, Herpes_teg_N, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51521, HTUSP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTP_MUHVK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8E1C4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: November 13, 2007
Last modified: April 7, 2021
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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