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Protein

Immunoglobulin superfamily member 2

Gene

Cd101

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells (By similarity).By similarity

GO - Biological processi

  • positive regulation of myeloid leukocyte differentiation Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-202433 Generation of second messenger molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 2
Short name:
IgSF2
Alternative name(s):
Glu-Trp-Ile EWI motif-containing protein 101
Short name:
EWI-101
CD_antigen: CD101
Gene namesi
Name:Cd101
Synonyms:Igsf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2685862 Cd101

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 970ExtracellularSequence analysisAdd BLAST950
Transmembranei971 – 991HelicalSequence analysisAdd BLAST21
Topological domaini992 – 1033CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000036395121 – 1033Immunoglobulin superfamily member 2Add BLAST1013

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 121PROSITE-ProRule annotation
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 249PROSITE-ProRule annotation
Disulfide bondi304 ↔ 377PROSITE-ProRule annotation
Disulfide bondi432 ↔ 509PROSITE-ProRule annotation
Disulfide bondi560 ↔ 638PROSITE-ProRule annotation
Glycosylationi677N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi695 ↔ 776PROSITE-ProRule annotation
Disulfide bondi832 ↔ 925PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiA8E0Y8
PaxDbiA8E0Y8
PRIDEiA8E0Y8

PTM databases

PhosphoSitePlusiA8E0Y8

Expressioni

Gene expression databases

BgeeiENSMUSG00000086564 Expressed in 14 organ(s), highest expression level in brain
ExpressionAtlasiA8E0Y8 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116643

Structurei

3D structure databases

ProteinModelPortaliA8E0Y8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 141Ig-like C2-type 1Add BLAST120
Domaini144 – 266Ig-like C2-type 2Add BLAST123
Domaini279 – 388Ig-like C2-type 3Add BLAST110
Domaini408 – 529Ig-like C2-type 4Add BLAST122
Domaini539 – 657Ig-like C2-type 5Add BLAST119
Domaini670 – 797Ig-like C2-type 6Add BLAST128
Domaini806 – 941Ig-like C2-type 7Add BLAST136

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi253 – 255EWI motif3

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFBX Eukaryota
ENOG410YWQX LUCA
GeneTreeiENSGT00390000010278
HOGENOMiHOG000293322
HOVERGENiHBG107997
InParanoidiA8E0Y8
KOiK06522
OMAiQAVWEGE
OrthoDBiEOG091G00OL
PhylomeDBiA8E0Y8
TreeFamiTF332702

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 3 hits
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 3 hits
SM00406 IGv, 5 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 7 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A8E0Y8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACILCVASL FLSLTKFSIG QREVKIQEGP LYRAEGYPVS IRCTVSGHQG
60 70 80 90 100
PSTQDFRWSI YLPSAPTKEV QIISTKDAGF SYAVYAQRVQ SKEIYIERLQ
110 120 130 140 150
GDSVLLHISK LQMKDAGEYE CHTPNTDGKY FGSYSAKTNL TVVPDTLSAT
160 170 180 190 200
MPSQTLSKKE GEPLELTCET TKATVQHTHL SLTWYLMQEG GGSQATEIVS
210 220 230 240 250
LSKDFVLTPG SSYADRFVAG DVRLDKLGAT SFRLSVGKLQ PSDQGQVFCE
260 270 280 290 300
ATEWIQDPDE TWTLITRKQT DQTALRIQPA ARDFTVSITA SSSPDEGKPL
310 320 330 340 350
ELVCLAVGRD GNPQLQGVWF LNGKEIAQTD AGGVLDLKRD YRDRASQGQL
360 370 380 390 400
QVSKLSAQTF SLKIFSVGPE DVGTYSCEVA EVARTQMGSW QVLQRKQSPG
410 420 430 440 450
YRVQLREPAA RSVTVSAEQR TVWEGETLTL LCKAAGDVSA LSVSWWLTPQ
460 470 480 490 500
DQSTPVFVAG MGQDGTVQLG VSSPGPAHRG NRRLEKVDWA TFRLEIASAM
510 520 530 540 550
VTDSGTYECR VSERLQNQAK GLQSTQKISV TVKSLKSSLR VNLMSRQPQV
560 570 580 590 600
MLAHTFHLSC VVRANYSDLK LPFSVTWQFQ PAGSGAFHRL IRIAHNGTVE
610 620 630 640 650
WGDVLSQIHR KTKVSQSFFR SQLQIYDAAM EETGVYRCTV EVYDRDSICT
660 670 680 690 700
SGPARVSATS NLLMITVTFP ESKLSVNSSS QVQELSISSS TQIECAILSR
710 720 730 740 750
SAGNLPLSII WYFSSVSANA SYLKILEMDQ SSVVKYGDEF QTPRSKQKFY
760 770 780 790 800
SEKVSQDLFL LNILSVEDSD QGHYHCAVEE WLLSTNDTWQ KLERKTSGLT
810 820 830 840 850
ELKLRPTGSQ VHVSKVNWTG NATEYGEAGF SCSLDGSGST ASLYSVTWYR
860 870 880 890 900
GRGTATATAA AVANATATIT APAGSQMLVH LQYDGLLQYG REGSRRLQHC
910 920 930 940 950
YRSSPTDFVL KLHRVEMEDA GIYWCRVTEW QQHGHPGKWI NQASGESQRM
960 970 980 990 1000
VLRVLRSEPT VSSLICSSGP LLHFLIVCPF VMLLLLATSF LCLYRKARKL
1010 1020 1030
SQLSLSAKKE KALWVGMRKT SLQKEAGEES GHY
Length:1,033
Mass (Da):114,205
Last modified:November 13, 2007 - v1
Checksum:iE0A0DD07DE0927C0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J1L8A0A0B4J1L8_MOUSE
Immunoglobulin superfamily member 2
Cd101
1,029Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti175V → A in strain: NOD/MrkTac. 1
Natural varianti296E → K in strain: NOD/MrkTac. 1
Natural varianti318V → A in strain: NOD/MrkTac. 1
Natural varianti392V → I in strain: NOD/MrkTac. 1
Natural varianti451D → N in strain: NOD/MrkTac. 1
Natural varianti557H → D in strain: NOD/MrkTac. 1
Natural varianti565N → D in strain: NOD/MrkTac. 1
Natural varianti620R → H in strain: NOD/MrkTac. 1
Natural varianti648I → M in strain: NOD/MrkTac. 1
Natural varianti860A → T in strain: NOD/MrkTac. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849328 mRNA Translation: CAO94506.1
AM849329 mRNA Translation: CAO94507.1
CCDSiCCDS51020.1
RefSeqiNP_001161378.1, NM_001167906.1
UniGeneiMm.190915

Genome annotation databases

EnsembliENSMUST00000147399; ENSMUSP00000116643; ENSMUSG00000086564
GeneIDi630146
KEGGimmu:630146
UCSCiuc012cuu.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM849328 mRNA Translation: CAO94506.1
AM849329 mRNA Translation: CAO94507.1
CCDSiCCDS51020.1
RefSeqiNP_001161378.1, NM_001167906.1
UniGeneiMm.190915

3D structure databases

ProteinModelPortaliA8E0Y8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000116643

PTM databases

PhosphoSitePlusiA8E0Y8

Proteomic databases

MaxQBiA8E0Y8
PaxDbiA8E0Y8
PRIDEiA8E0Y8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000147399; ENSMUSP00000116643; ENSMUSG00000086564
GeneIDi630146
KEGGimmu:630146
UCSCiuc012cuu.1 mouse

Organism-specific databases

CTDi9398
MGIiMGI:2685862 Cd101

Phylogenomic databases

eggNOGiENOG410IFBX Eukaryota
ENOG410YWQX LUCA
GeneTreeiENSGT00390000010278
HOGENOMiHOG000293322
HOVERGENiHBG107997
InParanoidiA8E0Y8
KOiK06522
OMAiQAVWEGE
OrthoDBiEOG091G00OL
PhylomeDBiA8E0Y8
TreeFamiTF332702

Enzyme and pathway databases

ReactomeiR-MMU-202433 Generation of second messenger molecules

Miscellaneous databases

PROiPR:A8E0Y8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000086564 Expressed in 14 organ(s), highest expression level in brain
ExpressionAtlasiA8E0Y8 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 3 hits
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 3 hits
SM00406 IGv, 5 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIGSF2_MOUSE
AccessioniPrimary (citable) accession number: A8E0Y8
Secondary accession number(s): A8E0Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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