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UniProtKB - A8DZ02 (A8DZ02_DROME)

Entry version 123 (07 Apr 2021)
Sequence version 2 (30 Nov 2010)
Previous versions | rss
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Protein
Submitted name:

Kuzbanian, isoform F

Gene

kuz

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Kuzbanian, isoform FImported (EC:3.4.24.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kuzImported
Synonyms:11410Imported, 34DaImported, ADAM10Imported, BG:DS07660.3Imported, br38Imported, CT22079Imported, Dmel\CG7147Imported, GS11410Imported, KUZImported, KuzImported, l(2)03782Imported, l(2)34DaImported, l(2)br38Imported, l(2)c00136Imported, l(2)k01403Imported, l34DaImported, soy nutImported
ORF Names:CG7147Imported, Dmel_CG7147Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0259984, kuz

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 24HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesARBA annotation, Disulfide bondARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		A8DZ02

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0259984, Expressed in central nervous system and 43 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A8DZ02, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A8DZ02, DM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A8DZ02

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini430 – 658Peptidase M12BInterPro annotationAdd BLAST229
Domaini675 – 781DisintegrinInterPro annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni157 – 196DisorderedSequence analysisAdd BLAST40
Regioni210 – 245DisorderedSequence analysisAdd BLAST36
Regioni307 – 337DisorderedSequence analysisAdd BLAST31
Regioni384 – 410DisorderedSequence analysisAdd BLAST27
Regioni935 – 1080DisorderedSequence analysisAdd BLAST146
Regioni1109 – 1219DisorderedSequence analysisAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi210 – 236PolarSequence analysisAdd BLAST27
Compositional biasi1030 – 1065PolarSequence analysisAdd BLAST36
Compositional biasi1119 – 1147PolarSequence analysisAdd BLAST29
Compositional biasi1159 – 1192PolarSequence analysisAdd BLAST34

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000167746

Family and domain databases

Conserved Domains Database

More...CDDi		cd04270, ZnMc_TACE_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.390.10, 1 hit
4.10.70.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034025, ADAM10_ADAM17
IPR001762, Disintegrin_dom
IPR036436, Disintegrin_dom_sf
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00200, Disintegrin, 1 hit
PF01562, Pep_M12B_propep, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00050, DISIN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57552, SSF57552, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50214, DISINTEGRIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A8DZ02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKCAFNIV FVSIIFIIIV NGYAKDISGV KRGHERLNEY ISHYETLNYD 
        60         70         80         90        100
HEHIRASHNR ARRSVTKDQY VHLKFASHGR DFHLRLKRDL NTFSNKLDFY 
       110        120        130        140        150
DSKGPIDVST DHIYEGEVIG DRNSYVFGSI HNGVFEGKII TERDAYYVEH 
       160        170        180        190        200
AKHYFPTNRT ATTTPPSTST TSSATTATKS TQPTRPLAKS NTSTTAVNSK 
       210        220        230        240        250
TENFIKKIAE STTTSQQLPE YTESSSSSTT TFPPTTEYFE DEKERNAEDE 
       260        270        280        290        300
LDFHSIIYKE SHVEDAYENV REGHVAGCGI TDEVSQWMEN IQNSAVEELP 
       310        320        330        340        350
EPMSKDYQKL HRKQLHKKSA PQQQQQPHPP KKYISGDEDF KYPHQKYTKE 
       360        370        380        390        400
ANFAEGAFYD PSTGRRLGSS ANVADWHQLV HERVRRATDN GAGDRGSSGG 
       410        420        430        440        450
SGRGREDNKN TCSLYIQTDP LIWRHIREGI ADHDRGRKYE VDEKTREEIT 
       460        470        480        490        500
SLIAHHVTAV NYIYRNTKFD GRTEHRNIRF EVQRIKIDDD SACRNSYNGP 
       510        520        530        540        550
HNAFCNEHMD VSNFLNLHSL EDHSDFCLAY VFTYRDFTGG TLGLAWVASA 
       560        570        580        590        600
SGASGGICEK YKTYTETVGG QYQSTKRSLN TGIITFVNYN SRVPPKVSQL 
       610        620        630        640        650
TLAHEIGHNF GSPHDYPQEC RPGGLNGNYI MFASATSGDR PNNSKFSPCS 
       660        670        680        690        700
IRNISNVLDV LVGNTKRDCF KASEGAFCGN KIVESGEECD CGFNEEECKD 
       710        720        730        740        750
KCCYPRLISE YDQSLNSSAK GCTRRAKTQC SPSQGPCCLS NSCTFVPTSY 
       760        770        780        790        800
HQKCKEETEC SWSSTCNGTT AECPEPRHRD DKTMCNNGTA LCIRGECSGS 
       810        820        830        840        850
PCLLWNMTKC FLTSTTLPHV SKRKLCDLAC QDGNDTSTCR STSEFADKYN 
       860        870        880        890        900
IQKGGISLQP GSPCDNFQGY CDVFLKCRAV DADGPLLRLK NLLLNRKTLQ 
       910        920        930        940        950
TVAEWIVDNW YLVVLMGVAF IVVMGSFIKC CAVHTPSSNP KKRRARRISE 
       960        970        980        990       1000
TLRAPMNTLR RMQRHPNQRG AGPRSIPPPA HEAQHYSRGG DGRGGGGGGG 
      1010       1020       1030       1040       1050
GRHGGSRSHH QQHPHDWDRH QGGHSIVPLP TGGSHSSRNS AANQARRSDG 
      1060       1070       1080       1090       1100
RGPRSTSSGR PQAIASGSGA ASGAARSHGG YGAEQAIPGS IGGGVQAAIS 
      1110       1120       1130       1140       1150
SGGVVARAQL PLPLPPPNGQ QQMQQQQQLQ LQQPAISPQQ QPQQAFYTPK 
      1160       1170       1180       1190       1200
GVAPPPLQVS FSRPTSLHEQ QQQQHHLQQQ QQHQQQLEPQ QQHAYADAYA 
      1210 
ALGRGQYEST TRAPNNSKV
Length:1,219
Mass (Da):135,260
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69DCE5F48B592EB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VJW9Q9VJW9_DROME
Kuzbanian, isoform A
kuz 11410, 34Da, ADAM10, BG:DS07660.3, br38
1,238Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8DZ03A8DZ03_DROME
Kuzbanian, isoform G
kuz 11410, 34Da, ADAM10, BG:DS07660.3, br38
1,161Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q59DZ3Q59DZ3_DROME
FI21209p1
kuz 11410, 34Da, ADAM10, BG:DS07660.3, br38
1,090Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014134 Genomic DNA Translation: ABV53680.2

NCBI Reference Sequences

More...RefSeqi		NP_001097160.2, NM_001103690.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0301412; FBpp0290626; FBgn0259984

Database of genes from NCBI RefSeq genomes

More...GeneIDi		34772

UCSC genome browser

More...UCSCi		CG7147-RE, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: ABV53680.2
RefSeqiNP_001097160.2, NM_001103690.3

3D structure databases

SMRiA8DZ02
ModBaseiSearch...

Proteomic databases

PRIDEiA8DZ02

Genome annotation databases

EnsemblMetazoaiFBtr0301412; FBpp0290626; FBgn0259984
GeneIDi34772
UCSCiCG7147-RE, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		34772
FlyBaseiFBgn0259984, kuz

Phylogenomic databases

GeneTreeiENSGT00940000167746

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		34772, 1 hit in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		kuz, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		34772

Gene expression databases

BgeeiFBgn0259984, Expressed in central nervous system and 43 other tissues
ExpressionAtlasiA8DZ02, baseline and differential
GenevisibleiA8DZ02, DM

Family and domain databases

CDDicd04270, ZnMc_TACE_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR034025, ADAM10_ADAM17
IPR001762, Disintegrin_dom
IPR036436, Disintegrin_dom_sf
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
PfamiView protein in Pfam
PF00200, Disintegrin, 1 hit
PF01562, Pep_M12B_propep, 1 hit
SMARTiView protein in SMART
SM00050, DISIN, 1 hit
SUPFAMiSSF57552, SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50214, DISINTEGRIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8DZ02_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8DZ02
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 30, 2010
Last modified: April 7, 2021
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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