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Entry version 108 (11 Dec 2019)
Sequence version 1 (13 Nov 2007)
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Protein

Obscurin

Gene

Unc-89

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural component of the muscle M line which is involved in assembly and organization of sarcomere (PubMed:22467859, PubMed:26251439). Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere (PubMed:22467859, PubMed:26251439). Likely to have serine/threonine-protein kinase activity as one of the two protein kinase domains appears to be functional (Probable).Curated2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei3215ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3311Proton acceptorPROSITE-ProRule annotation1
Binding sitei3926ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi3192 – 3200ATPPROSITE-ProRule annotation9
Nucleotide bindingi3903 – 3911ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Muscle protein, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
A8DYP0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ObscurinBy similarity (EC:2.7.11.1By similarity)
Alternative name(s):
Muscle M-line assembly protein Unc-89By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Unc-891 PublicationImported
ORF Names:CG33519Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0053519 Unc-89

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown either in the indirect flight muscles (IFM) or in all muscles prevents flies from flying without affecting jumping and slightly reduces larval crawling (PubMed:22467859). Causes severe defects in IFM sarcomere development and organization resulting in narrower myofibrils (PubMed:22467859). During sarcomere development at the pupal stage, myosin is mislocalized and no regular sarcomeres are formed (PubMed:22467859). In the adult, abnormal localization of myosin in the mid-region of the sarcomere, H zone shifts from the middle of the sarcomere and M lines are less defined (PubMed:22467859). Thick filaments are asymmetric with the bare zone often shifted towards the end of the filament (PubMed:22467859). Thick filament length is mostly normal although some are longer and by-pass the Z line (PubMed:22467859). Thin filaments are abnormally shorter or longer and sometimes extend into the H zone (PubMed:22467859). Several Z and M lines associated proteins are mislocalized (PubMed:22467859, PubMed:26251439). zormin is more diffused in both Z and M lines and tropomodulin is confined to the core of the myofibril in the H zone (PubMed:22467859). ball is still partially localized to the Z line but appears more diffuse across the sarcomere compare to wild type (PubMed:26251439). mask localization to Z lines is not affected but is absent or in a punctate form in the M line (PubMed:26251439). kettin localization to the Z line is not affected (PubMed:22467859).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004389251 – 4218ObscurinCuratedAdd BLAST4218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1199 ↔ 1282PROSITE-ProRule annotation
Disulfide bondi2739 ↔ 2790PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8DYP0

PRoteomics IDEntifications database

More...
PRIDEi
A8DYP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the thoracic muscles including the indirect flight muscles (IFM) (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression starts in embryos at stage 16 and is found in the M line of somatic muscle during late larval stage 17, pupa and in pharate adult. The various isoforms are expressed differentially during development.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression decreases with age.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0053519 Expressed in 18 organ(s), highest expression level in oviduct (Drosophila)

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A8DYP0 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with myosin (PubMed:22467859). May interact (via protein kinase domain 1) with ball (PubMed:26251439). May interact (via protein kinase domain 1 or 2) with mask (PubMed:26251439). May interact (via protein kinase domain 2) with Tm1/tropomyosin-1 (PubMed:26251439).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A8DYP0, 13 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0112375

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A8DYP0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 71SH3PROSITE-ProRule annotationAdd BLAST69
Domaini86 – 264DHPROSITE-ProRule annotationAdd BLAST179
Domaini1017 – 1103Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST87
Domaini1152 – 1298Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST147
Domaini1313 – 1400Ig-like C2-type 3PROSITE-ProRule annotationAdd BLAST88
Domaini1504 – 1594Ig-like C2-type 4PROSITE-ProRule annotationAdd BLAST91
Domaini1599 – 1689Ig-like C2-type 5PROSITE-ProRule annotationAdd BLAST91
Domaini1694 – 1785Ig-like C2-type 6PROSITE-ProRule annotationAdd BLAST92
Domaini1815 – 1906Ig-like C2-type 7PROSITE-ProRule annotationAdd BLAST92
Domaini2018 – 2107Ig-like C2-type 8PROSITE-ProRule annotationAdd BLAST90
Domaini2113 – 2214Ig-like C2-type 9PROSITE-ProRule annotationAdd BLAST102
Domaini2220 – 2305Ig-like C2-type 10PROSITE-ProRule annotationAdd BLAST86
Domaini2318 – 2409Ig-like C2-type 11PROSITE-ProRule annotationAdd BLAST92
Domaini2415 – 2505Ig-like C2-type 12PROSITE-ProRule annotationAdd BLAST91
Domaini2519 – 2609Ig-like C2-type 13PROSITE-ProRule annotationAdd BLAST91
Domaini2614 – 2698Ig-like C2-type 14PROSITE-ProRule annotationAdd BLAST85
Domaini2716 – 2792Ig-like C2-type 15PROSITE-ProRule annotationAdd BLAST77
Domaini2832 – 2933Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST102
Domaini3186 – 3440Protein kinase 1PROSITE-ProRule annotationAdd BLAST255
Domaini3654 – 3738Ig-like C2-type 16PROSITE-ProRule annotationAdd BLAST85
Domaini3750 – 3843Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini3897 – 4151Protein kinase 2PROSITE-ProRule annotationAdd BLAST255

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi499 – 586Pro-richPROSITE-ProRule annotationAdd BLAST88
Compositional biasi739 – 785Pro-richPROSITE-ProRule annotationAdd BLAST47

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain 2 is predicted to be catalytically inactive.PROSITE-ProRule annotationCurated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032 Eukaryota
KOG4240 Eukaryota
KOG4475 Eukaryota
ENOG410XQFD LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8DYP0

Identification of Orthologs from Complete Genome Data

More...
OMAi
KCGEKSH

Database for complete collections of gene phylogenies

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PhylomeDBi
A8DYP0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 23 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR000719 Prot_kinase_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 21 hits
PF00069 Pkinase, 2 hits
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 21 hits
SM00408 IGc2, 18 hits
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF48726 SSF48726, 21 hits
SSF49265 SSF49265, 2 hits
SSF50044 SSF50044, 1 hit
SSF56112 SSF56112, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 15 hits
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced.1 Publication
Isoform CImported (identifier: A8DYP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAVADIVFV SRDYQAQSLA TDEISVSRGD LVELISSKAS EKSRCFVRMF
60 70 80 90 100
DSGDSPKEGW VPIDILEFNP TMSSSNGKES GDAEFRKLTI LRELVETEEE
110 120 130 140 150
FSRDLLHVVE KYIKGIDKPV VPRSVRDNKD IIFCNFLQIA EFHNNVLKEG
160 170 180 190 200
LKCYSNQPNM VAKTFLRLER DFDKHVVYCQ NEPLAQDYLG SSPDAKKYFQ
210 220 230 240 250
ELSKQLGDDK SLAEHLKLPI QRINDYQLLF KDFIKYSLSL KENVKDLERA
260 270 280 290 300
LELMLSVPSR AYDNRFLSSI EGCRGNIYKL GRLLLHAWCN VVDKEGKAHD
310 320 330 340 350
RYCFLFKSRI LVTKVRKISE NRSVFILQNI VKLPLCNIEL KADEKQIHLS
360 370 380 390 400
LKAPEANSFL PIDIKPHGPE AHLTWFNEIS SHINQDVTLQ EHNADDLKVD
410 420 430 440 450
ASQIASESEL ILHLPQRAEA HDPNLSVRPS DVAENYFLSK ETKERLQHEQ
460 470 480 490 500
QELLKLEQEA IELYKKQQSS KSVSSKTESV EITSSQVKSS SEVRKVVSPP
510 520 530 540 550
PPPQAQVKEV TPVKVVSSPP PPKEITPAKV ATPPPQPQVV TSPVKEVAPP
560 570 580 590 600
PQPRAVASPA KEVTPSQSEP VKAPSPIKEV RKEVPPSASH SKEVEALVAT
610 620 630 640 650
EIRESLTETR STVVESGQSS EIREEIVVTE ESSLEGKQVV ALEREPSPCS
660 670 680 690 700
IPKIQVYRPV ECENPVVTKH KPIELKDIVG YSESLRDGDT APAGGSPGRQ
710 720 730 740 750
QGYSANITDH ASLTIWNNRL ANIAGDRSGA NQHLQQSGPP PPPIPPNFTR
760 770 780 790 800
MPGFFQPLPL IAYETTIEIL IVKARPPSPP PPPPPTIKRV LVHTESLEQK
810 820 830 840 850
TQNFFEGIYD AASSDTSLRN AKQKIRSIKS TVLKSKDSTN YAQDTVQKAK
860 870 880 890 900
ARDFLHIFTP PVKKRPIYEI VEEPVNIFEL EGDYTESIAD DFREPSADFE
910 920 930 940 950
ARGQSVGGMD DYYSGYSRAS TRRYETKTRD YDRGTSYDST VERSQYGISS
960 970 980 990 1000
RRDRSSVDKV EARSSLLATG RTESRAASRA ESRAESRASY SVAESRAGIR
1010 1020 1030 1040 1050
SSSRLQEDRP LRSVDKPVVV KMLKSVQVEP GETAHFEIQF KDQPGLVTWL
1060 1070 1080 1090 1100
KDNKPLEDRL ADRITQTAAP MNSYRLDIKN CSETDAGTYT IRAQSASETT
1110 1120 1130 1140 1150
TVSAQLAVGQ APGHDETKTN TEPAFLVSLK DAEMIENTLF RFMVKIIGDP
1160 1170 1180 1190 1200
KPRVKFYKDE KEILETNDRI QIIRDKDYLG FYELVIADVQ KTDAGTYSCK
1210 1220 1230 1240 1250
ATNKHGEANC EAIATTVEDK NPFGALSGQI LPAGEKPVFQ WKRNGEEFDP
1260 1270 1280 1290 1300
EERFKVLFGE DEDSLALVFQ HVKPEDAGIY TCVAQTSTGN ISCSAELSVQ
1310 1320 1330 1340 1350
GAIQTLNREP EKPTLVIEHR EANASIGGSA ILELQCKGFP KPAVQWKHDG
1360 1370 1380 1390 1400
EVIQVDDRHK FMYEDEESMS LVIKNVDTVD AGVYTIEAIN ELGQDESSIN
1410 1420 1430 1440 1450
LVVKAPPKIK KITDITCSAG ETIKMEIEVE GFPQPTVQVT NNGKDVTAES
1460 1470 1480 1490 1500
NVKISSSSIG KSLEKVVVEV KEIKLSQAGN YSIKATNDLS QTSEYWSCTV
1510 1520 1530 1540 1550
KSKPVIVKNF ESEYIHGEKE NVQMTVRIDA YPEAKLTWYH DETEIKITDS
1560 1570 1580 1590 1600
KYTVSSDGNA YTLKITGATR VDAGKYTVKA TNEHGSATSS TQLLIKCAPE
1610 1620 1630 1640 1650
FTHKLKNITV AEGDSNVELV VGVDAYPRPH AKWYIDGIEI DEKRNDFRHV
1660 1670 1680 1690 1700
EEGNDFKLIM NQVATNMQGN YTCKIMNDYG KLEDNCVVTV NCKPKVKRGL
1710 1720 1730 1740 1750
KNVEVQEGKS FTLEVEVYSE PEAKIKWFKD GHEIYEDARI KISRDTQRIE
1760 1770 1780 1790 1800
NYYLTLNLAR TEDAGTYEMK ATNFIGETTS TCKVAVLTSE ALSLEQTVTK
1810 1820 1830 1840 1850
TLIATTEEPE EGAVPEIVHV DVFQQHSYES VPLKYEVIAT GIPKPEAIWY
1860 1870 1880 1890 1900
HDGKPITPDK HTAITVDGDH YKLEVQSLDL VDAGEYKVVV QNKVGEKSHQ
1910 1920 1930 1940 1950
GELSLSGIAE YRKPILTQGP GLKDIKVNKG DKVCEPVVFT ADPAPEIVLL
1960 1970 1980 1990 2000
KDGQPVVETN NVKLKVDKKD AENGLVQYTC TLNILEAEIK DSGRYELKVK
2010 2020 2030 2040 2050
NKYGELVTSG WIDVLAKPEI SGLNDTKCLP GDTICFEALV QANPKPKVSW
2060 2070 2080 2090 2100
TRGNENLCNH ENCEVIADVD ADKYRLVFQS VSPCEDGKYT ITATNSEGRA
2110 2120 2130 2140 2150
AVDFNLAVLV EKPTFIVQPE SQSIHDYRPV STKVLVHGVP LPTIEWFKDD
2160 2170 2180 2190 2200
KPINYEAINK PGKDKLYAKE DTKKGTDQIE SVLDIKSFRE NDVGAYTCVA
2210 2220 2230 2240 2250
TNEIGVTKAP FKLAMLSLAP SFVKKLDNAL DVLQGEPLVL ECCVDGSPLP
2260 2270 2280 2290 2300
TVQWLKDGDE VKPSESIKIS TNPDGLVKLE INSCQPNDSG AYKLIISNPH
2310 2320 2330 2340 2350
GEKVALCAVA VKPEEMQPKF LKPITSQTVV VGEPLKLEAQ VTGFPAPEVK
2360 2370 2380 2390 2400
WYKDGMLLRP SPEINFINSP NGQIGLIIDA AQPLDAGVYK CLIANKGGEI
2410 2420 2430 2440 2450
EGVSKVEIVP KESKPVFVAE LQDASSIEGF PVKMDIKVVG NPKPKLQWFH
2460 2470 2480 2490 2500
NGHEIKPDAS HIAIVENPDN SSSLIIEKTA PGDSGLYEVI AQNPEGSTAS
2510 2520 2530 2540 2550
KAKLYVAPKA DETATEEAPQ FVSALRDVNA DEGQELVLSA PFISNPMPEV
2560 2570 2580 2590 2600
IWSKDGVTLT PNERLLMTCD GKHIGLTIKP AEAADSGNYT CLLANPLGED
2610 2620 2630 2640 2650
SSACNANVRK VYKPPVFTQK ISDQQQVFGN NAKIPVTVSG VPYPDLEWYF
2660 2670 2680 2690 2700
QDKPIPKSEK YSIKNDGDHH MLIVNNCEKG DQGVYKCIAS NREGKDITQG
2710 2720 2730 2740 2750
RLDIVNEIKK HSRSEPPVFL KKIGDCDIYE GMVAKFTACA TGYPEPEVEW
2760 2770 2780 2790 2800
FKNDQKLFPS DRFLIDIEPN GLLRLTIKNV TEYDVGRYSC RIFNPYGDDI
2810 2820 2830 2840 2850
CHAELFYDSL DSQQKPLEDQ YTDFKKYKKS GAPPPLSEGP IISRMTDRGL
2860 2870 2880 2890 2900
LLSWNPSVPL TPRYPITYQI EMMDLPEGDW RTLRTGVRSC ACDIRNLEPF
2910 2920 2930 2940 2950
RDYRFRVRVE NKFGVSDPSP YTQTYRQKLV PDPPKTYTYL PPGTDFRPET
2960 2970 2980 2990 3000
SPYFPKDFDI ERPPHDGLAQ APQFLLREQD ISYGVKDHNT ELMWFVYGYP
3010 3020 3030 3040 3050
KPKMTYYFDD MLIESGGRFD QSYTRNGQAT LFINKMLDRD VGWYEAVATN
3060 3070 3080 3090 3100
EHGEARQRVR LEIAEHPRFL KRPDETFIMA RKNGRIEAKL VGIPLPEVHW
3110 3120 3130 3140 3150
FKDWKPIVDS SRIKISSYDP DIYVLSIHDS IIKDGGLYSI SARNIAGSIS
3160 3170 3180 3190 3200
TSVTVHIEEN EDQYIYKTYG RHPYVRSKQL RYQDKYDIGD ELGRGTQGIT
3210 3220 3230 3240 3250
YHAVERSSGD NYAAKIMYGR PELRPFMLNE LEMMNTFNHK NLIRPYDAYD
3260 3270 3280 3290 3300
TDRSVTLIME LAAGGELVRD NLLRRDYYTE RDIAHYIRQT LWGLEHMHEM
3310 3320 3330 3340 3350
GVGHMGLTIK DLLISVVGGD IIKVSDFGLS RKINRHNLST LDYGMPEFVS
3360 3370 3380 3390 3400
PEVVNKEGVN FSHDMWTVGL ITYVLLGGHN PFLGIDDRET LTKIREGRWD
3410 3420 3430 3440 3450
FKDEIWTHIS DDGRDFISRL LLYSPEERMD VKTALKHPWF FMLDRPVYDH
3460 3470 3480 3490 3500
DYQIGTDRLR NYYDHFRDWY ANASCKNYFR RRRLSGCFQH PSKMVYPPGH
3510 3520 3530 3540 3550
VYTPENTPEP LPEPRIRAKR EEVVSKYLHP DYELGLIQSE SHYQYGPDTY
3560 3570 3580 3590 3600
LLQLRDVNFP VRLREYMKVA HRRSPSFALN DSVDWSLPVI RERRRFTDIM
3610 3620 3630 3640 3650
DEEIDDERTR SRISMYAANE SYSIRRLRTE LGPRLDEYTE ADAMIETQRE
3660 3670 3680 3690 3700
GYPPFFREKP QTIAITENQP SHIHCFAVGD PKPCVQWFKN DMVLTESKRI
3710 3720 3730 3740 3750
KISVDEDGRS ILRFEPALHF DVGVYKVVAR NKVGQTVARC RIVVATLPDA
3760 3770 3780 3790 3800
PDSPEISANS GTEILLRWKQ PRDDGHSTVL CYSLQYKLSN CDAWTTVADN
3810 3820 3830 3840 3850
IDHEFYLLHD LQPNTNYQFR LASKNRIGWS EMGIPVSAST VGGDAPKIHI
3860 3870 3880 3890 3900
TKAMKHLQQL TENGHQVVPE EERVHTDYHC EREPPNWVTD SSVSDKYSFI
3910 3920 3930 3940 3950
SEIARGEFST IVKGIQKSTD TVVVAKILEV TDENEDNVVA EFDNFKTLRH
3960 3970 3980 3990 4000
ERIPALFSAY KPLNVPIAIF VMEKLQGADV LTYFSSRHEY SEQMVATVVT
4010 4020 4030 4040 4050
QLLDALQYLH WRGYCHLNIQ PDNVVMASVR SIQVKLVDFG SAKKVNKLGM
4060 4070 4080 4090 4100
KVTPCGSLDF QPPEMINDEP IFPQSDIWSL GALTYLLLSG CSPFRGADEY
4110 4120 4130 4140 4150
ETKQNISFVR YRFENLFKEV TPEATRFIML LFKRHPTKRP YTEDCLEHRW
4160 4170 4180 4190 4200
LMSSDYMVRK RERAIFLGSR LKTFCDEYHD LKNASATSSK VLNTVAGGPT
4210
PTQLLRSNSI QEELLTTF
Length:4,218
Mass (Da):475,655
Last modified:November 13, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAB9AA91F54A3E0A
GO
Isoform DImported (identifier: A8DYP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MDA → MDAQ
     1789-1813: Missing.

Show »
Length:4,194
Mass (Da):473,154
Checksum:i5970705B40ADA353
GO
Isoform EImported (identifier: A8DYP0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1789-1813: Missing.

Show »
Length:4,193
Mass (Da):473,026
Checksum:iF612CECA2DD99AC5
GO
Isoform FImported (identifier: A8DYP0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-253: Missing.

Show »
Length:3,965
Mass (Da):446,572
Checksum:i9B340372E73486A4
GO
Isoform HImported (identifier: A8DYP0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-908: Missing.

Show »
Length:3,310
Mass (Da):374,063
Checksum:iEB034F53C1B8A349
GO
Isoform GImported (identifier: A8DYP0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-926: GKQVVALERE...SRASTRRYET → A
     1789-1813: Missing.

Show »
Length:3,903
Mass (Da):440,794
Checksum:i61DD509E186782BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti145N → S in ABD83643 (PubMed:15185077).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0587631 – 908Missing in isoform H. CuratedAdd BLAST908
Alternative sequenceiVSP_0587641 – 253Missing in isoform F. CuratedAdd BLAST253
Alternative sequenceiVSP_0587651 – 3MDA → MDAQ in isoform D. Curated3
Alternative sequenceiVSP_058766636 – 926GKQVV…RRYET → A in isoform G. CuratedAdd BLAST291
Alternative sequenceiVSP_0587671789 – 1813Missing in isoform D, isoform E and isoform G. CuratedAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAX52680.3
AE013599 Genomic DNA Translation: ABV53900.1
AE013599 Genomic DNA Translation: AHN56598.1
AE013599 Genomic DNA Translation: AHN56599.1
AE013599 Genomic DNA Translation: AHN56600.1
AE013599 Genomic DNA Translation: AHN56601.1
DQ431841 mRNA Translation: ABD83643.1

NCBI Reference Sequences

More...
RefSeqi
NP_001014545.3, NM_001014545.3 [A8DYP0-2]
NP_001097440.1, NM_001103970.2 [A8DYP0-1]
NP_001286803.1, NM_001299874.1 [A8DYP0-3]
NP_001286804.1, NM_001299875.1 [A8DYP0-4]
NP_001286805.1, NM_001299876.1 [A8DYP0-5]
NP_001286806.1, NM_001299877.1 [A8DYP0-6]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0113464; FBpp0112375; FBgn0053519 [A8DYP0-1]
FBtr0343283; FBpp0309948; FBgn0053519 [A8DYP0-2]
FBtr0343284; FBpp0309949; FBgn0053519 [A8DYP0-3]
FBtr0343285; FBpp0309950; FBgn0053519 [A8DYP0-4]
FBtr0343286; FBpp0309951; FBgn0053519 [A8DYP0-5]
FBtr0343287; FBpp0309952; FBgn0053519 [A8DYP0-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3346201

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG33519

UCSC genome browser

More...
UCSCi
CG33519-RC d. melanogaster [A8DYP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAX52680.3
AE013599 Genomic DNA Translation: ABV53900.1
AE013599 Genomic DNA Translation: AHN56598.1
AE013599 Genomic DNA Translation: AHN56599.1
AE013599 Genomic DNA Translation: AHN56600.1
AE013599 Genomic DNA Translation: AHN56601.1
DQ431841 mRNA Translation: ABD83643.1
RefSeqiNP_001014545.3, NM_001014545.3 [A8DYP0-2]
NP_001097440.1, NM_001103970.2 [A8DYP0-1]
NP_001286803.1, NM_001299874.1 [A8DYP0-3]
NP_001286804.1, NM_001299875.1 [A8DYP0-4]
NP_001286805.1, NM_001299876.1 [A8DYP0-5]
NP_001286806.1, NM_001299877.1 [A8DYP0-6]

3D structure databases

SMRiA8DYP0
ModBaseiSearch...

Protein-protein interaction databases

IntActiA8DYP0, 13 interactors
STRINGi7227.FBpp0112375

Proteomic databases

PaxDbiA8DYP0
PRIDEiA8DYP0

Genome annotation databases

EnsemblMetazoaiFBtr0113464; FBpp0112375; FBgn0053519 [A8DYP0-1]
FBtr0343283; FBpp0309948; FBgn0053519 [A8DYP0-2]
FBtr0343284; FBpp0309949; FBgn0053519 [A8DYP0-3]
FBtr0343285; FBpp0309950; FBgn0053519 [A8DYP0-4]
FBtr0343286; FBpp0309951; FBgn0053519 [A8DYP0-5]
FBtr0343287; FBpp0309952; FBgn0053519 [A8DYP0-6]
GeneIDi3346201
KEGGidme:Dmel_CG33519
UCSCiCG33519-RC d. melanogaster [A8DYP0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3346201
FlyBaseiFBgn0053519 Unc-89

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
KOG4240 Eukaryota
KOG4475 Eukaryota
ENOG410XQFD LUCA
InParanoidiA8DYP0
OMAiKCGEKSH
PhylomeDBiA8DYP0

Enzyme and pathway databases

SignaLinkiA8DYP0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Unc-89 fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3346201

Protein Ontology

More...
PROi
PR:A8DYP0

Gene expression databases

BgeeiFBgn0053519 Expressed in 18 organ(s), highest expression level in oviduct (Drosophila)
GenevisibleiA8DYP0 DM

Family and domain databases

CDDicd00063 FN3, 2 hits
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 23 hits
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR000719 Prot_kinase_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 21 hits
PF00069 Pkinase, 2 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 21 hits
SM00408 IGc2, 18 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48726 SSF48726, 21 hits
SSF49265 SSF49265, 2 hits
SSF50044 SSF50044, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 15 hits
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOBSCN_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8DYP0
Secondary accession number(s): A0A0B4LGC9
, A0A0B4LGE3, A0A0B4LGI5, A0A0B4LHF2, Q1ZYJ8, Q59E65
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2017
Last sequence update: November 13, 2007
Last modified: December 11, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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