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Entry version 115 (29 Sep 2021)
Sequence version 2 (01 Apr 2015)
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Protein

Midasin

Gene

Dmel\CG13185

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperoneUniRule annotationARBA annotation, HydrolaseImported
LigandATP-bindingUniRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MidasinUniRule annotationARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dmel\CG13185Imported
Synonyms:CG18329Imported
ORF Names:CG13185Imported, Dmel_CG13185Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0033661, CG13185

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0033661

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8DYB0

PRoteomics IDEntifications database

More...
PRIDEi
A8DYB0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0033661, Expressed in midgut and 56 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8DYB0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A8DYB0, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0302006

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8DYB0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5322 – 5516VWFAInterPro annotationAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni124 – 143DisorderedSequence analysisAdd BLAST20
Regioni4594 – 5184DisorderedSequence analysisAdd BLAST591

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2942 – 2969Sequence analysisAdd BLAST28
Coiled coili3194 – 3221Sequence analysisAdd BLAST28
Coiled coili3225 – 3255Sequence analysisAdd BLAST31
Coiled coili3323 – 3343Sequence analysisAdd BLAST21
Coiled coili4263 – 4283Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi127 – 143Polar residuesSequence analysisAdd BLAST17
Compositional biasi4621 – 4677Basic and acidic residuesSequence analysisAdd BLAST57
Compositional biasi4678 – 4696Acidic residuesSequence analysisAdd BLAST19
Compositional biasi4706 – 4727Acidic residuesSequence analysisAdd BLAST22
Compositional biasi4728 – 4806Basic and acidic residuesSequence analysisAdd BLAST79
Compositional biasi4837 – 4851Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi4852 – 4884Acidic residuesSequence analysisAdd BLAST33
Compositional biasi4904 – 4918Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi4927 – 4958Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi4959 – 4980Polar residuesSequence analysisAdd BLAST22
Compositional biasi4981 – 5012Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi5020 – 5120Basic and acidic residuesSequence analysisAdd BLAST101
Compositional biasi5121 – 5151Acidic residuesSequence analysisAdd BLAST31
Compositional biasi5152 – 5180Basic and acidic residuesSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the midasin family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1808, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000050_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8DYB0

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELGPPNI

Database of Orthologous Groups

More...
OrthoDBi
138219at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8DYB0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 3 hits
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR040848, AAA_lid_7
IPR011704, ATPase_dyneun-rel_AAA
IPR012099, Midasin
IPR041190, Midasin_AAA_lid_5
IPR027417, P-loop_NTPase
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07728, AAA_5, 6 hits
PF17865, AAA_lid_5, 1 hit
PF17867, AAA_lid_7, 3 hits
PF00092, VWA, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010340, Midasin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 6 hits
SSF53300, SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8DYB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVNVSKLRL GAQRLLELTA NESEDNVFSQ SLQKFIKKQK YVPQDVERLF
60 70 80 90 100
RSLSEQLPLP AYTVPIAASF EEQLLLLLSM ALRWDSASQR FHTYQLECVA
110 120 130 140 150
LSKLMNFSLD AQRFAKSYFH DKPAPFEKQQ SNGSLPSKKS KNGNHAADNL
160 170 180 190 200
DDLELIKCCF QLLKSDTPYF RELWDWSSFI ATYTHNSSSP KTQLYCNYIV
210 220 230 240 250
AMLTNMSAPQ LNSLNEKIST KTRLEFDQER EQAWNTARNT LCSYTPDASD
260 270 280 290 300
QLLNLHLHGI NKSVTNIEGV LLPTFNEENL EFYASTDGCY DRIVKVDSTV
310 320 330 340 350
VNLRSIALGV AAAKPICLSG PVGCGKTTLI EYLARKTGRI CPKPNEIESR
360 370 380 390 400
EKALKKAEEE EQLLTPKKKA KTTGSKRKLE EVPLEELLDL GETTKKSGFL
410 420 430 440 450
RIQLGDQTDS KMLLGQYRCT DVPGEFVWLP GVLTQAVMHG YWLLLEDLDA
460 470 480 490 500
ATQDTYTILS SLLERQCLSV PGFRDSVKIE PGFQLFVTVR TNKSASNSSQ
510 520 530 540 550
KSLYSLLDKY LYTINILPLS RNELCKMVSI NYPKLSTVAN RIVDVFLTFS
560 570 580 590 600
SGNHTSADNL RQQESGDKAD NTEQYVALPF EQVPLTSSPN SGRLVSTRDL
610 620 630 640 650
VKLCHRSNPQ FSVTSSECAY FVFQNAVDVF CSYLPQSKEK VTLITSIGAK
660 670 680 690 700
LGIIRSRCEH FANEYKPDVE FGLEHIKIGR ASLLAKSDLN NSENEDISEQ
710 720 730 740 750
DLKRQKLSQQ TRRAIGKVSN KRTTFSFTRL ASCILERIAV CVTHSEPVLL
760 770 780 790 800
VGETGVGKTS SVQYLAERTE HKLVVVNMNN QSDVSDLVGG FKPVELNYVL
810 820 830 840 850
APLRNEFEYL LCETFNQEKN LQFLRLFATH YNSGRHAVII RTMINICLQV
860 870 880 890 900
AKNPELKANK LLPRWQTLRE KLQKLQMQLD KSINISFAFI PGSLVNCISN
910 920 930 940 950
GDWVLLDEIN LASAETLECL STILEPEGSV VLLERGDFTP VKRHPDFRIF
960 970 980 990 1000
ACMNPNTDIG KKDLPVGIRN RFTEFFVDEL TTDADLSLLV SDYLANTGIQ
1010 1020 1030 1040 1050
RKSVHNIVQL YKSLRKLSEL QLNDGLGNRP VYSLRTLCRS LRICARNLCG
1060 1070 1080 1090 1100
SIERNLYESF CLSFLTQLDP NSHHVVLLLI QNALLSNVKA ILSKQLPQLG
1110 1120 1130 1140 1150
ENYLDFEGYW IQPGNLEPQP CTHYILTESV KKNLKDLARI ISIGKLPILL
1160 1170 1180 1190 1200
QGPTSAGKTS LIDYVARRSG NRCLRINNHE HTDLQEYIGT YAADLDGKLT
1210 1220 1230 1240 1250
FREGVLVQAM RHGFWIILDE LNLASTDILE ALNRVLDDNR ELYIAETQTL
1260 1270 1280 1290 1300
VKAHPNFMLF ATQNPPGLYG GRKTLSRAFK NRFIELHFAD IPREELETIL
1310 1320 1330 1340 1350
EKRCFIPPTY ARKMVQCMTQ LQQHRKNTSK QVFTLRDLFR WGNRYTHADK
1360 1370 1380 1390 1400
SLHDDNRYDW NQHLVEEGYL VLSSKVRSQE EHELIEKTLF ANFRKKLDLQ
1410 1420 1430 1440 1450
TLFDIQTDRE SSSMVSRKIL DAIRNFKLRD DIVWTRNMTR MAVVTAKALE
1460 1470 1480 1490 1500
FDEPVLLVGP TGCGKTTVCQ LLASIADVQL RILNCHMHTE GADFLGGLRP
1510 1520 1530 1540 1550
CRGKESTQLF EWADGPLIYA MQEGSYFMAD EISLAEDSVL ERLNCILEPE
1560 1570 1580 1590 1600
RTVLLAEKGG ISELDASPDF VVQAKSGFQF LATMNPGGDF GKKELSPALR
1610 1620 1630 1640 1650
NRFTEVWCLP SDNKEDLIEI AYNCMRRQKE HENQAINTHK VAEYLVDVVL
1660 1670 1680 1690 1700
HIRDTNDKFK FSVRDILAWA NYMVSNAKLS FAEQAIFGLE TIFLDALEML
1710 1720 1730 1740 1750
PHESQEQVEL LKSNIVKQAI KQASLILQEK FTLEELSEKR GTEVELNECR
1760 1770 1780 1790 1800
FGIRPFFIDV NQERLTSAKE DFLFDAPTTK QNLFRLLSAL SLQKPVLLEG
1810 1820 1830 1840 1850
PPGVGKTSIV ESIGSAIGYQ IVRINLCEHT DLADLFGTDL PAEDNLLESN
1860 1870 1880 1890 1900
TAATERQIRS FVWRDGPLLA ALKAKNTWIL LDELNLAPQS VLEGLNAVLD
1910 1920 1930 1940 1950
HRGEVYIPEL NKSFHLAGST RIFACQNPLK QGGGRKGLPQ SFLNRFTKVY
1960 1970 1980 1990 2000
LRKLSTEDLL HVVTEKYGKY FDQLNAYFLE LLDQKAEGNL FEIYSGKESS
2010 2020 2030 2040 2050
CKSDSFDLGA RLVRFSEQLD RGVASMEFGY KGGPYEFNLR DILRWCDLLH
2060 2070 2080 2090 2100
NPQTGYILGA SPSSFQAAFK DFLLTLYERM QLVYYQRMRC DQDKSYIRNV
2110 2120 2130 2140 2150
FSTVFLCDAE YLNQVSNDVA LYWTADKVYL NDVVLSRKQA DVLDLVNRQE
2160 2170 2180 2190 2200
QSPLLLDSQR QQLKQIIETV HMEKPLLLCG STDSGKTKLI DALCVLSNRL
2210 2220 2230 2240 2250
CNTDIIDDSV TGSFQQIDLN RHLEIIYKKV ETLVFSCVQR AFVLHTQSEF
2260 2270 2280 2290 2300
VEQLWNNWSM YNKLAKVTTE AQQHSVLDEL KLFSERLGSL GKIIEVLEAT
2310 2320 2330 2340 2350
PQNCQVRALQ QLAEIKSQLL LLQTYIKTAD SLNTGGSFEW VDSQIVTSLK
2360 2370 2380 2390 2400
CGQYILLEHV NLCSSAVLDR LNPVFEPNGS LLIAEKGISA QDSAEVVYKS
2410 2420 2430 2440 2450
TNFRAFLTVD PKNGELSRAM RNRCVELSLS RDTYSVDDLR AFVHEQGVRE
2460 2470 2480 2490 2500
MEAIDCILRV HKGLSQLTEF NNYSISHLTQ FAFLSAAYRR IGYELKRAIY
2510 2520 2530 2540 2550
VAAMEVYVYS ANTDLMGYGL SYYQNKLREV VLAQTEVFEE VAVIQEDFLS
2560 2570 2580 2590 2600
DVILNSGNLN SLTLIKRQAV ALKVLLDGYT EGKIPQKLLA SLFHEMEKLK
2610 2620 2630 2640 2650
LDQRNPQKLI RHFLYMLYES SAIGDLELRH LYLQPWLSKD TAFQELSQNL
2660 2670 2680 2690 2700
YNCLQKRSNT DTGTLANLPW NRKLIPRLRD YSTAESNSEL NPLNLSALLL
2710 2720 2730 2740 2750
ARLVVDIIPV SSVTTVQQMN ALQYSQALCK KQVTEKYANH LLANFSSFLE
2760 2770 2780 2790 2800
VLHTSLLEDL ETADLDLPQY AHLVTRFHWF NRILATAQQK LLYNNELHVP
2810 2820 2830 2840 2850
LMHKLVLHFQ WLEKHLLVPL IELTAKSGCA RMLTIQDRTL KIKKYIEETR
2860 2870 2880 2890 2900
RPLNVTCKIY SKQFTQFQPY YQDQQIQRHI ELDDLEKLLS VVPSYGNLEL
2910 2920 2930 2940 2950
SSWLKRWLLL QTDDANKWRS FLRKHTNGFQ PKAFEISGSL RNETLQSHLQ
2960 2970 2980 2990 3000
KLQTTLKEAQ ENSAEIEMDL ELDLNSIKTL LEAETEESES YIHPDGIPTN
3010 3020 3030 3040 3050
TPKLLIAALR ELFMERLLTG TLRDDFDEQV NPLYADQLLT LNSNLWHCLK
3060 3070 3080 3090 3100
TLESANRTEI TNAWIELKNE VNELQNYDEF AVLLEKIGGG YKGLRSYQRQ
3110 3120 3130 3140 3150
YRNSVQCYQL ENLSTRLDCV QGPSEEGSTD ISSQFCYRGP ALSGVILSLI
3160 3170 3180 3190 3200
CQPNGQLRSV PLSELLEWRS ALQQTRHLIW ENSQLLTSRY SGEVNNLLQA
3210 3220 3230 3240 3250
KENARQLLKE LEYVRKLSEK EQKANQGFEN CAKELEKMIE KLEKEENNNA
3260 3270 3280 3290 3300
SMTKDFEVSL TNALVGAIEL CLLTNTPLID PVEKNRLKNE YIAEDIDCLS
3310 3320 3330 3340 3350
TLTTAYDFMK IAMKYRHFGE EIYSELELRL RTALQRQQQL SQKLALRSEK
3360 3370 3380 3390 3400
CLYASLVQDI THFLHSNGDC ESLYKLFQLI HSEWENFQGL HVATSAQLKS
3410 3420 3430 3440 3450
SIEVLGKLDL WLANAQRFVH HTLSRYSAYY QDFVEPIKCS VNQLRFGLES
3460 3470 3480 3490 3500
LKVIFTRVQQ AGSVSQAEQM QQTIGDIVQF PSQHPLVIRN SRLYGLLAEL
3510 3520 3530 3540 3550
PHSEYEYFRL LKAKLSELSN YIALGRVIDE TTFAAYDDAL SICNQTWQQE
3560 3570 3580 3590 3600
EHRRCQLKAE AESLYVTKTK GGVDSEELIE MQEIEHNFPT NLDEDFAEFV
3610 3620 3630 3640 3650
SQPTLEQVLK LDKKASAKDK QSQIVVEEDY AFLARNFIDV MTRHTQVYYK
3660 3670 3680 3690 3700
EQPKSSKELE LHLLAPYQAR FQVFANLHGH YKTALGSSLE ERACNGLAFG
3710 3720 3730 3740 3750
LALQQKQLRD IELEEGVSSS PYDFYKDSNI SEIQSCLDVM ERIEKRVLEQ
3760 3770 3780 3790 3800
LEQYPEHAGL ADIKLVISRI RRLPAHAPVV RFNTGFQLLR QKLALWNEVA
3810 3820 3830 3840 3850
HRNNNLVSEE IEVAEFVQRW TRLELQHWRN CLGQTAAQVE LQAYRYWFFI
3860 3870 3880 3890 3900
YNLLQQFIHQ KQLDHSYTDI KLAEQRFAQD HLLDAQDLGE SQRLELAQVV
3910 3920 3930 3940 3950
RILRQFVEAS CYGDFHIRLQ LLQGFELYLH NVERAGKING LPPLIAALHN
3960 3970 3980 3990 4000
LQLYFSQFAG EIADSAKLRR SPIEKKLKEF VKIQSYSKDL SYFSMRNSVA
4010 4020 4030 4040 4050
SVHRNLNKFL KEYRLSIQEK ISEVFQPKDS TAKDYTFGTD KGKGLRNYNK
4060 4070 4080 4090 4100
IKYLHTERQQ FVASEKLLEK FAIQEEFLSD NTLLQRLDKH FRTARHVVKE
4110 4120 4130 4140 4150
TLGQVPYGEL ITELDDLLAS QLERCEHLRS LNVDRSKERP QQKQEAKQIL
4160 4170 4180 4190 4200
QQKRKALTDL FKMLHRLGAN YKTGLLELSL RNEFEDFQLP PYSIRSMLPR
4210 4220 4230 4240 4250
LHPTAQQLDE HLDLYYMKSV FKLKLLQNIM LTPLSELGPP NIERIKGFAV
4260 4270 4280 4290 4300
DLFLLVQQQR EHLSGSTKEL HELRNSLDSL RKLAEIIPQA DINPSTLNFV
4310 4320 4330 4340 4350
KSADIAMEIK QHLRQIHYVL KQWKLLLSCA PSSFIEESEN RLLVRKISLA
4360 4370 4380 4390 4400
QSELHSLCIQ ILNSSQELLN ELNNANLEYL SSEKCVTYQK SYAEIQENIK
4410 4420 4430 4440 4450
KTLELLRTGQ NDYLPLAQPI VELLDSVQLK NHTEIAPEAI DLANADTELA
4460 4470 4480 4490 4500
NIAHSVLMSM QKIYKHHVKT DEVNQNGEAK EQDEESKEAL QEQHLKKCLT
4510 4520 4530 4540 4550
GELTSDWQQL SLPRVLGKLS NVLLVLKHSH FEGKDKLLCV RRAIGLLPVL
4560 4570 4580 4590 4600
EQYQLLADYL LLQQLATHKV SAKMLSIVLT VFVEIGSKGF CVPPDLMQDE
4610 4620 4630 4640 4650
EGQSKQESKN GEGFGLEDGT GENDASDKIE SEDQLDDAKR PEDRKDEGDK
4660 4670 4680 4690 4700
QEPDCKEEKG IEMSDDFDAK MQDVEKPEED DSGESEEEED LNKEMGETEE
4710 4720 4730 4740 4750
GAEKLDDQIW GDDEEEKPEE EQEPDMNEED QGKGSKDEKD AHNDLDTKND
4760 4770 4780 4790 4800
AAKEDGKDEH EKDGLDATNE PSGEDKRKEQ AKDIDDMKDP EMDEEQTNAM
4810 4820 4830 4840 4850
HNELEEPPEP EEMDLGDMNN VDEGHDDQDE QPTDENPFDI DAMKENMQPA
4860 4870 4880 4890 4900
EEPEADGDDE HDANEEGDPQ SDGSDSEEDE AGTEAKPAEE DHGEGEEATP
4910 4920 4930 4940 4950
EDEKDEAETQ KRGELEDEDD SKPEDSPEDS KEEKEEKREE KPEEHSQSKD
4960 4970 4980 4990 5000
KASKEENVQS MPETDQSSSA DQVQQPQDPD IKQDQKLDEQ ETGEEKDGVG
5010 5020 5030 5040 5050
QAENDADDGG HQGVAETQET VSQEDRKNER QTQEKRKQGR TNEERSLGEA
5060 5070 5080 5090 5100
EQNKLKQLKT IDQLKDSKES DDAEQEKPEP MDQTEAEEYQ HVKEPKNSDK
5110 5120 5130 5140 5150
TTLDNATEEQ SKKIQHQEDE PPNEEEIEAE NVDELMEAEE PAVDPEDDAE
5160 5170 5180 5190 5200
LEQLGAEKTE QKSDKPSKTE KSKEQLETPE GMEIEGEVVL TMTVPRSSET
5210 5220 5230 5240 5250
TAHSNSEILL DKSSHAEDLS SAEQIELRQQ YQKQLTTFRV AQPEHEDYET
5260 5270 5280 5290 5300
WQGISNRMTQ NARELCEQLR LILEPTKCTR LKGDYRTGRR INMKKIIPYI
5310 5320 5330 5340 5350
ASQFRKDKIW LRRTKPAQRD YKITIAIDDS KSMHHNNSKT LTLEAISLVS
5360 5370 5380 5390 5400
QALTLLESGR LSIVSFGEAP QIILNHTEQF DGPRLVNALN FAQDKTKIAG
5410 5420 5430 5440 5450
LLNFIRTANA EESGTGGDNG LFENLLLILS DGRNIFSEGA QNVKNAIKLA
5460 5470 5480 5490 5500
RLQRIFLVYI IIDNPDNKNS ILDIQHVAVN ADGSVNINSY LDSFPFPYYV
5510 5520
IVRDLNQLPL VLSEAMRQWF ELVNSE
Length:5,526
Mass (Da):631,328
Last modified:April 1, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB3E7B1500EE3ED9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE013599 Genomic DNA Translation: ABV53770.2

NCBI Reference Sequences

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RefSeqi
NP_001097279.2, NM_001103809.3

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0310323; FBpp0302006; FBgn0033661

Database of genes from NCBI RefSeq genomes

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GeneIDi
36268

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG13185

UCSC genome browser

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UCSCi
CG13185-RC, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: ABV53770.2
RefSeqiNP_001097279.2, NM_001103809.3

3D structure databases

SMRiA8DYB0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0302006

Proteomic databases

PaxDbiA8DYB0
PRIDEiA8DYB0

Genome annotation databases

EnsemblMetazoaiFBtr0310323; FBpp0302006; FBgn0033661
GeneIDi36268
KEGGidme:Dmel_CG13185
UCSCiCG13185-RC, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0033661, CG13185
VEuPathDBiVectorBase:FBgn0033661

Phylogenomic databases

eggNOGiKOG1808, Eukaryota
HOGENOMiCLU_000050_0_2_1
InParanoidiA8DYB0
OMAiELGPPNI
OrthoDBi138219at2759
PhylomeDBiA8DYB0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36268, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36268

Gene expression databases

BgeeiFBgn0033661, Expressed in midgut and 56 other tissues
ExpressionAtlasiA8DYB0, baseline and differential
GenevisibleiA8DYB0, DM

Family and domain databases

Gene3Di3.40.50.300, 3 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR040848, AAA_lid_7
IPR011704, ATPase_dyneun-rel_AAA
IPR012099, Midasin
IPR041190, Midasin_AAA_lid_5
IPR027417, P-loop_NTPase
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF07728, AAA_5, 6 hits
PF17865, AAA_lid_5, 1 hit
PF17867, AAA_lid_7, 3 hits
PF00092, VWA, 1 hit
PIRSFiPIRSF010340, Midasin, 4 hits
SMARTiView protein in SMART
SM00382, AAA, 5 hits
SUPFAMiSSF52540, SSF52540, 6 hits
SSF53300, SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234, VWFA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8DYB0_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8DYB0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: April 1, 2015
Last modified: September 29, 2021
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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