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Entry version 116 (02 Jun 2021)
Sequence version 1 (13 Nov 2007)
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Protein
Submitted name:

Toutatis, isoform E

Gene

tou

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulationARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Toutatis, isoform EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:touImported
Synonyms:anon-48AdImported, Dm TouImported, Dmel\CG10897Imported, EP(2)0622Imported, EP0622Imported, EP622Imported, gene VIImported, TIP5Imported, TOUImported, TouImported, VIImported
ORF Names:CG10897Imported, Dmel_CG10897Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0033636, tou

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8DYA3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0033636, Expressed in embryo and 41 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8DYA3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A8DYA3, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0111979

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8DYA3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini948 – 1021MBDInterPro annotationAdd BLAST74
Domaini1254 – 1317DDTInterPro annotationAdd BLAST64
Domaini2638 – 2688PHD-typeInterPro annotationAdd BLAST51
Domaini2692 – 2744PHD-typeInterPro annotationAdd BLAST53
Domaini3039 – 3109BromoInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni186 – 230DisorderedSequence analysisAdd BLAST45
Regioni268 – 306DisorderedSequence analysisAdd BLAST39
Regioni332 – 425DisorderedSequence analysisAdd BLAST94
Regioni455 – 507DisorderedSequence analysisAdd BLAST53
Regioni519 – 572DisorderedSequence analysisAdd BLAST54
Regioni650 – 684DisorderedSequence analysisAdd BLAST35
Regioni757 – 782DisorderedSequence analysisAdd BLAST26
Regioni823 – 880DisorderedSequence analysisAdd BLAST58
Regioni921 – 944DisorderedSequence analysisAdd BLAST24
Regioni1081 – 1125DisorderedSequence analysisAdd BLAST45
Regioni1513 – 1569DisorderedSequence analysisAdd BLAST57
Regioni1584 – 1618DisorderedSequence analysisAdd BLAST35
Regioni1747 – 1843DisorderedSequence analysisAdd BLAST97
Regioni1889 – 1909DisorderedSequence analysisAdd BLAST21
Regioni2047 – 2068DisorderedSequence analysisAdd BLAST22
Regioni2382 – 2403DisorderedSequence analysisAdd BLAST22
Regioni2437 – 2464DisorderedSequence analysisAdd BLAST28
Regioni2510 – 2560DisorderedSequence analysisAdd BLAST51
Regioni2584 – 2637DisorderedSequence analysisAdd BLAST54
Regioni2747 – 2832DisorderedSequence analysisAdd BLAST86
Regioni2843 – 2862DisorderedSequence analysisAdd BLAST20
Regioni2925 – 2952DisorderedSequence analysisAdd BLAST28
Regioni2966 – 2998DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili603 – 623Sequence analysisAdd BLAST21
Coiled coili3001 – 3028Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 21Polar residuesSequence analysisAdd BLAST21
Compositional biasi193 – 207Polar residuesSequence analysisAdd BLAST15
Compositional biasi332 – 358Polar residuesSequence analysisAdd BLAST27
Compositional biasi368 – 425Polar residuesSequence analysisAdd BLAST58
Compositional biasi455 – 495Polar residuesSequence analysisAdd BLAST41
Compositional biasi540 – 572Polar residuesSequence analysisAdd BLAST33
Compositional biasi762 – 782Polar residuesSequence analysisAdd BLAST21
Compositional biasi1540 – 1554Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1747 – 1783Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi2440 – 2455Polar residuesSequence analysisAdd BLAST16
Compositional biasi2511 – 2531Basic residuesSequence analysisAdd BLAST21
Compositional biasi2546 – 2560Polar residuesSequence analysisAdd BLAST15
Compositional biasi2584 – 2605Polar residuesSequence analysisAdd BLAST22
Compositional biasi2761 – 2784Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi2932 – 2951Pro residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WAL family.ARBA annotation

Keywords - Domaini

BromodomainPROSITE-ProRule annotationARBA annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0383, Eukaryota
KOG1245, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156831

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8DYA3

Identification of Orthologs from Complete Genome Data

More...
OMAi
DICGYHE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8DYA3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05503, Bromo_BAZ2A_B_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037374, BAZ2A/B_Bromo
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR018501, DDT_dom
IPR016177, DNA-bd_dom_sf
IPR001739, Methyl_CpG_DNA-bd
IPR028942, WHIM1_dom
IPR028941, WHIM2_dom
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439, Bromodomain, 1 hit
PF02791, DDT, 1 hit
PF01429, MBD, 1 hit
PF00628, PHD, 2 hits
PF15612, WHIM1, 1 hit
PF15613, WSD, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00571, DDT, 1 hit
SM00391, MBD, 1 hit
SM00249, PHD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF54171, SSF54171, 1 hit
SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit
PS50827, DDT, 1 hit
PS50982, MBD, 1 hit
PS50016, ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A8DYA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKNAGDGSD GKNSNKNSNA GGGGGAGGPH DPTGLLDAAS LFAYWGRDPT
60 70 80 90 100
GAAAAAASNP LFNSQFNAAA AAGLGLLPQA GGASANDRYS MAAAAAAAAG
110 120 130 140 150
AHHHQNTMAV AASQAASLAG LHPASWWSMA QLAAQDYFSR LQASGLSPFP
160 170 180 190 200
HPDLAAAFGP AGMGMGGGAG GAGAGGGGAG VLGQGGGGNG GSGNGGGGSS
210 220 230 240 250
SGSSGSKSNK SRKEKRAAQQ QQQQQQNLAN SLNAAAAAAA AAAANNPAAA
260 270 280 290 300
LASMHGFGVG VPGTSIPSVS TGSGSISTNS GGHGSYKSTA SAYGKPSTMT
310 320 330 340 350
SSSMANNPGS AYDPVTLHKE LLAMQAVAAA ASGSGSSGSS GKKSGGGGSS
360 370 380 390 400
SSSMHSLGMG IGGSGGMMSS GKASTSVSAS NSSLGGMHPS LTSSNPLMSP
410 420 430 440 450
HAGMGSSSSS SSKDRDKNNP SLNALNSLSQ FGALGMTPQQ SMQAAMNAFA
460 470 480 490 500
ASTGVSPSAT VTSSPHHSSQ QQQQMGGNSS TSGSGKSSSK DYMMGTGSEH
510 520 530 540 550
PSLLGVRLPP DTEIIKYTSS IVGPKIPGTT SRGRKKTISE TEQQTTQQQQ
560 570 580 590 600
KQQHQAEQHL LQQQQQAQKE LDSTKNAISS LLAFPGLSPA KRARLEMEYA
610 620 630 640 650
AMAAAAQQQH QQAQQQHQAQ QQLHGMLGAA GIPGMAGLVG LPGMSGNPLD
660 670 680 690 700
QLSVSKASSS TAPTTSTSSS SAGSNLLNQS NSDRVEVIKL PPTITSNGAY
710 720 730 740 750
NLSSKGKEVH DLTTDMATNS GGVNLSLKSN AGSSALTPSG AVGSASNPIT
760 770 780 790 800
IDDFDAPLNL SMKPSDKSNS SSSNAAAGGS SSSSAALANL ASDYQAASSG
810 820 830 840 850
QSGNSLQSLS SITAALGGTG GMPGGSISGS GGTSPAPAGA GSGATGGGSG
860 870 880 890 900
SGGSGGGSSS YKEGRPRNLG RGVSKPKKNT VASLLAQSRA VGLKPMLATQ
910 920 930 940 950
QLLQQGADIE KIRLALSEAN AHMETSTDSE SVAAESGLSE SESEDANILN
960 970 980 990 1000
VAELRVPLEL GWKRETVIRG LTKQGQIRGE VTYYAPGSTT PLKSNGQVFA
1010 1020 1030 1040 1050
ILEQQPSNLS RENFSFSARA IVGSFLQPAP PPYANDGEYI RMTDEDVAKR
1060 1070 1080 1090 1100
LEDLKVFTRQ TLNVEQRIEI AKQQQAMRDA KKLQKEELAR NKEKARQEKN
1110 1120 1130 1140 1150
SKLEQQRKDK ELKNQQAVEE RKKRQEELDR LKQEELLKKQ QEKEKRRQEA
1160 1170 1180 1190 1200
ILAKEQELQK QKEMLLAAEM ERERRRQHMS LIRMLELRRK FEDREKKKHQ
1210 1220 1230 1240 1250
LVLDRLLLRE RRMAERKRDA EILQLIRRPN EDSEMPQELV IPELDRIAGN
1260 1270 1280 1290 1300
RLPGQAMADL LMVFEFLHNF GETLGFDMES LPSLQNLHDA LMSDSNADAE
1310 1320 1330 1340 1350
EELLSVMTHL LVCAIEDPGV PNPGRHTTLL GQSLRNADIT NSNVSEILRI
1360 1370 1380 1390 1400
YLYATATGEV RQMHGITVDR ERERRVPDHH QLDSDTTTHS HSVKNQEYYK
1410 1420 1430 1440 1450
LLHENDTWKL SQSLKDRPFV ALNPTRKAQM LAHLCNDLLM NKAVLRQIDG
1460 1470 1480 1490 1500
SLETCAQMRK EKYMTDMKVR KYKALHMRKA RIEAYERAQA EREAAMQALM
1510 1520 1530 1540 1550
AQQKLDAERL KAEEEAKAAA AEEAAAAAGT DGEATKGGSP NGEKPEDGDQ
1560 1570 1580 1590 1600
NEEGAAKEPQ QQQQQPMEVD GVVDEASLVS PAKTIIQTDN SLTPSKQDMP
1610 1620 1630 1640 1650
TPTYQINGSS TPTTSGVTGG DMNVLLQAKK SGARNSINDE HHHDVSIIDD
1660 1670 1680 1690 1700
DLSDLDSEIT NVEEDEDNRL SADELQKKLD KIVRASLNCK EALEKSTNQL
1710 1720 1730 1740 1750
RAACFGQDRF WRRYWKLPKA GGIFIEALES AQNDICDYHE ALEAMDDKKD
1760 1770 1780 1790 1800
ANDEKENSEN EKDVAAESSE QPMEVDESIT KLEDGVPASD VGMPESNQQN
1810 1820 1830 1840 1850
AHQDEEDDDD DVTEINKVEP EIVDLGDDDD DAAPPLPKIE PPRPEIKVKS
1860 1870 1880 1890 1900
EMELMGPPPT TMISTKTDFE AEIKIPSMPG ILMPPTLNNN NTNNNNNNNG
1910 1920 1930 1940 1950
SDNCDKLETG LGLGQQQQNF SQSVIKTEDV KKEDDCIIVS TSSVDDTPKW
1960 1970 1980 1990 2000
FSIVRREVPL ISELPAEEGG VVGQELQISY ANQNCSAQLQ LQGHPWDLIN
2010 2020 2030 2040 2050
NMQYYSIPMD ECKVDTSKLG NECIFSLSGL DEKQMLAKVE EYKAHKVESK
2060 2070 2080 2090 2100
NGLGSPHRHH ETKDDEEQAK LKLDKEIDTE METDADDLAG KEKFFRLRSD
2110 2120 2130 2140 2150
VPPDTGGGVS EGTDVKPKIE LRLDEALSQA YYHNIANMSL SSVQTYIPID
2160 2170 2180 2190 2200
IPLPLSMTPD EHRLLEQVKL AGFPERVHGV YVPRRQRYGW WQLDDEQKLR
2210 2220 2230 2240 2250
QLLKTLNPSG LRERELQENL QRFLGLEQPL GVNYKLKSDI DFPEEFLMPD
2260 2270 2280 2290 2300
KKGDWNPKVA KRVELALIEQ LESLEDKVAS ASMQLKNWQL PNRVESELTL
2310 2320 2330 2340 2350
DSQEDVTEED FVSIIPMIRE RIIDLEANIE RRYLKPPLGS QTGDAHLAVI
2360 2370 2380 2390 2400
AQNQHTTTQT QNSASAAAYL LQMQQQQQQQ QLAQQQQQQQ QGSGAGNSLN
2410 2420 2430 2440 2450
PSSFNERTMA LAAAAAASGP GNATGVANSA VVAGATPCES GSGEPNSGNA
2460 2470 2480 2490 2500
SPASNCDSDR DEKVEQIPKG LVQWRDAVSR SHTTAQLAMA LYVLESCVAW
2510 2520 2530 2540 2550
DKSIMKAYAT KNKSSKKKSS AKKQATPSKK QQQKKNKKEQ QLTPNGKESK
2560 2570 2580 2590 2600
SKSAINKPEN QAPLSIKINL KALAQNGQCL LKTKTPPILT KSPTASPSSH
2610 2620 2630 2640 2650
PNTSDSDSDF GKRTKKKSGG KRRRSANNTN SSKYSNSLQN CQFCTSGENE
2660 2670 2680 2690 2700
DKLLLCDGCD KGYHTYCFKP KMDNIPDGDW YCYECVNKAT NERKCIVCGG
2710 2720 2730 2740 2750
HRPSPVGKMI YCDLCPRAYH ADCYIPPLLK VPRGKWYCHG CISRAPPPKK
2760 2770 2780 2790 2800
RSAGGTSGSS SKSRRDRDRE SGGSAKRRSD NSKTPAMEHM QQQQMPLAGG
2810 2820 2830 2840 2850
DSHHHHHQQP PSLNSSHDES MNSLPAAPLS PAHSVVSATN YDDQHHANNS
2860 2870 2880 2890 2900
VDGSSRFHAH LIPPSNNGTA ALLEDVPGGA NVMPGVYPVY TPVAAGNFSA
2910 2920 2930 2940 2950
GLINQAPVQP AMPFANVVAM SPRAVTPTRT RTPTPTPAPT PPPPPPTPLL
2960 2970 2980 2990 3000
MQASPTATAL HVNACQSPPQ QQHAQLMTMP SPPAIGVGTA TNQMSPPPIN
3010 3020 3030 3040 3050
IHAIQEAKEK LKQEKKEKHA TKKLMKELAV CKTLLGEMEL HEDSWPFLLP
3060 3070 3080 3090 3100
VNTKQFPTYR KIIKTPMDLS TIKKKLQDLS YKTREDFCVD VRQIFDNCEM
3110 3120 3130
FNEDDSPVGK AGHGMRKFFE SRWGELTDKH S
Length:3,131
Mass (Da):336,605
Last modified:November 13, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C7B7C18E7B07B47
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A1Z8M2A1Z8M2_DROME
Toutatis, isoform A
tou anon-48Ad, Dm Tou, Dmel\CG10897, EP(2)0622, EP0622
2,999Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KFE3A0A0B4KFE3_DROME
Toutatis, isoform F
tou anon-48Ad, Dm Tou, Dmel\CG10897, EP(2)0622, EP0622
3,058Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KEM1A0A0B4KEM1_DROME
Toutatis, isoform G
tou anon-48Ad, Dm Tou, Dmel\CG10897, EP(2)0622, EP0622
3,094Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q95T46Q95T46_DROME
GH22615p
tou anon-48Ad, Dm Tou, Dmel\CG10897, EP(2)0622, EP0622
249Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE013599 Genomic DNA Translation: ABV53763.1

NCBI Reference Sequences

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RefSeqi
NP_001097270.1, NM_001103800.3

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0113066; FBpp0111979; FBgn0033636

Database of genes from NCBI RefSeq genomes

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GeneIDi
36241

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG10897

UCSC genome browser

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UCSCi
CG10897-RE, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: ABV53763.1
RefSeqiNP_001097270.1, NM_001103800.3

3D structure databases

SMRiA8DYA3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0111979

Proteomic databases

PaxDbiA8DYA3

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
36241

Genome annotation databases

EnsemblMetazoaiFBtr0113066; FBpp0111979; FBgn0033636
GeneIDi36241
KEGGidme:Dmel_CG10897
UCSCiCG10897-RE, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
36241
FlyBaseiFBgn0033636, tou

Phylogenomic databases

eggNOGiKOG0383, Eukaryota
KOG1245, Eukaryota
GeneTreeiENSGT00940000156831
InParanoidiA8DYA3
OMAiDICGYHE
PhylomeDBiA8DYA3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
36241, 1 hit in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
36241

Gene expression databases

BgeeiFBgn0033636, Expressed in embryo and 41 other tissues
ExpressionAtlasiA8DYA3, baseline and differential
GenevisibleiA8DYA3, DM

Family and domain databases

CDDicd05503, Bromo_BAZ2A_B_like, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR037374, BAZ2A/B_Bromo
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR018501, DDT_dom
IPR016177, DNA-bd_dom_sf
IPR001739, Methyl_CpG_DNA-bd
IPR028942, WHIM1_dom
IPR028941, WHIM2_dom
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439, Bromodomain, 1 hit
PF02791, DDT, 1 hit
PF01429, MBD, 1 hit
PF00628, PHD, 2 hits
PF15612, WHIM1, 1 hit
PF15613, WSD, 2 hits
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00571, DDT, 1 hit
SM00391, MBD, 1 hit
SM00249, PHD, 2 hits
SUPFAMiSSF47370, SSF47370, 1 hit
SSF54171, SSF54171, 1 hit
SSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit
PS50827, DDT, 1 hit
PS50982, MBD, 1 hit
PS50016, ZF_PHD_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8DYA3_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8DYA3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 2, 2021
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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