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UniProtKB - A8DUV3 (A8DUV3_MOUSE)

Entry version 86 (02 Dec 2020)
Sequence version 1 (13 Nov 2007)
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Protein
Submitted name:

Alpha-globin

Gene

Hbat1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi59Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi88Iron (heme proximal ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processOxygen transportPROSITE-ProRule annotationARBA annotation, Transport
LigandHemePROSITE-ProRule annotationARBA annotation, Iron, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alpha-globinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hbat1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		A8DUV3

PRoteomics IDEntifications database

More...PRIDEi		A8DUV3

PTM databases

SwissPalm database of S-palmitoylation events

More...SwissPalmi		A8DUV3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A8DUV3, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A8DUV3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 142GLOBINInterPro annotationAdd BLAST140

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...CDDi		cd08927, Hb-alpha_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.490.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000971, Globin
IPR009050, Globin-like_sf
IPR012292, Globin/Proto
IPR002338, Haemoglobin_a-typ
IPR002339, Haemoglobin_pi

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00042, Globin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00612, ALPHAHAEM
PR00815, PIHAEM

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46458, SSF46458, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01033, GLOBIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8DUV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS 
        60         70         80         90        100
HGSAQVKGHG KKVADALASA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK 
       110        120        130        140 
LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR
Length:142
Mass (Da):15,085
Last modified:November 13, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F70043BFF66E24A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
EF605405 Genomic DNA Translation: ABU63213.1
EF605407 Genomic DNA Translation: ABU63215.1
EF605410 Genomic DNA Translation: ABU63218.1
EF605412 Genomic DNA Translation: ABU63220.1
EF605416 Genomic DNA Translation: ABU63224.1
EF605422 Genomic DNA Translation: ABU63230.1
EF605423 Genomic DNA Translation: ABU63231.1
EF605424 Genomic DNA Translation: ABU63232.1
EF605425 Genomic DNA Translation: ABU63233.1
EF605426 Genomic DNA Translation: ABU63234.1
EF605427 Genomic DNA Translation: ABU63235.1
EF605428 Genomic DNA Translation: ABU63236.1
EF605429 Genomic DNA Translation: ABU63237.1
EF605430 Genomic DNA Translation: ABU63238.1
EF605431 Genomic DNA Translation: ABU63239.1
EF605432 Genomic DNA Translation: ABU63240.1
EF605433 Genomic DNA Translation: ABU63241.1
EF605434 Genomic DNA Translation: ABU63242.1
EF605435 Genomic DNA Translation: ABU63243.1
EF605436 Genomic DNA Translation: ABU63244.1
EF605437 Genomic DNA Translation: ABU63245.1
EF605438 Genomic DNA Translation: ABU63246.1
EF605439 Genomic DNA Translation: ABU63247.1
EF605440 Genomic DNA Translation: ABU63248.1
EF605441 Genomic DNA Translation: ABU63249.1
EF605442 Genomic DNA Translation: ABU63250.1
EF605443 Genomic DNA Translation: ABU63251.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF605405 Genomic DNA Translation: ABU63213.1
EF605407 Genomic DNA Translation: ABU63215.1
EF605410 Genomic DNA Translation: ABU63218.1
EF605412 Genomic DNA Translation: ABU63220.1
EF605416 Genomic DNA Translation: ABU63224.1
EF605422 Genomic DNA Translation: ABU63230.1
EF605423 Genomic DNA Translation: ABU63231.1
EF605424 Genomic DNA Translation: ABU63232.1
EF605425 Genomic DNA Translation: ABU63233.1
EF605426 Genomic DNA Translation: ABU63234.1
EF605427 Genomic DNA Translation: ABU63235.1
EF605428 Genomic DNA Translation: ABU63236.1
EF605429 Genomic DNA Translation: ABU63237.1
EF605430 Genomic DNA Translation: ABU63238.1
EF605431 Genomic DNA Translation: ABU63239.1
EF605432 Genomic DNA Translation: ABU63240.1
EF605433 Genomic DNA Translation: ABU63241.1
EF605434 Genomic DNA Translation: ABU63242.1
EF605435 Genomic DNA Translation: ABU63243.1
EF605436 Genomic DNA Translation: ABU63244.1
EF605437 Genomic DNA Translation: ABU63245.1
EF605438 Genomic DNA Translation: ABU63246.1
EF605439 Genomic DNA Translation: ABU63247.1
EF605440 Genomic DNA Translation: ABU63248.1
EF605441 Genomic DNA Translation: ABU63249.1
EF605442 Genomic DNA Translation: ABU63250.1
EF605443 Genomic DNA Translation: ABU63251.1

3D structure databases

SMRiA8DUV3
ModBaseiSearch...

Protein-protein interaction databases

IntActiA8DUV3, 1 interactor

PTM databases

SwissPalmiA8DUV3

Proteomic databases

PeptideAtlasiA8DUV3
PRIDEiA8DUV3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Hba-a1, mouse

Family and domain databases

CDDicd08927, Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971, Globin
IPR009050, Globin-like_sf
IPR012292, Globin/Proto
IPR002338, Haemoglobin_a-typ
IPR002339, Haemoglobin_pi
PfamiView protein in Pfam
PF00042, Globin, 1 hit
PRINTSiPR00612, ALPHAHAEM
PR00815, PIHAEM
SUPFAMiSSF46458, SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033, GLOBIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8DUV3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8DUV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: December 2, 2020
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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