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Entry version 107 (16 Oct 2019)
Sequence version 1 (13 Nov 2007)
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Protein
Submitted name:

Beta-globin

Gene

Hbb-bs

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi64Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi93Iron (heme proximal ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processOxygen transportPROSITE-ProRule annotationSAAS annotation, Transport
LigandHemePROSITE-ProRule annotationSAAS annotation, Iron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-MMU-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-MMU-2168880 Scavenging of heme from plasma
R-MMU-6798695 Neutrophil degranulation
R-MMU-9613829 Chaperone Mediated Autophagy
R-MMU-9615710 Microautophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Beta-globinImported
Submitted name:
Globin a1Imported
Submitted name:
Hemoglobin, beta adult s chainImported
Submitted name:
Hemoglobin, beta adult t chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hbb-bsImported
Synonyms:Glna1Imported, Hbb-btImported, Hbbt1Imported, Hbbt2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:5474852 Hbb-bs
MGI:5474850 Hbb-bt

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3546

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000052305 Expressed in 35 organ(s), highest expression level in spleen

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 147GLOBINInterPro annotationAdd BLAST146

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3378 Eukaryota
COG1018 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156216

KEGG Orthology (KO)

More...
KOi
K13823

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVKWTEE

Database of Orthologous Groups

More...
OrthoDBi
1370439at2759

TreeFam database of animal gene trees

More...
TreeFami
TF333268

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08925 Hb-beta_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.490.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00042 Globin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00814 BETAHAEM

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46458 SSF46458, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01033 GLOBIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A8DUK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVHLTDAEKA AVSGLWGKVN ADEVGGEALG RLLVVYPWTQ RYFDSFGDLS
60 70 80 90 100
SASAIMGNAK VKAHGKKVIT AFNDGLNHLD SLKGTFASLS ELHCDKLHVD
110 120 130 140
PENFRLLGNM IVIVLGHHLG KDFTPAAQAA FQKVVAGVAA ALAHKYH
Length:147
Mass (Da):15,748
Last modified:November 13, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6CF0EAEBF1F3E8D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q223E9Q223_MOUSE
Hemoglobin, beta adult s chain
Hbb-bs
103Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC131116 Genomic DNA No translation available.
EF605350 Genomic DNA Translation: ABU63178.1
EF605351 Genomic DNA Translation: ABU63179.1
EF605353 Genomic DNA Translation: ABU63181.1
EF605360 Genomic DNA Translation: ABU63188.1
EF605362 Genomic DNA Translation: ABU63190.1
EF605363 Genomic DNA Translation: ABU63191.1
EF605364 Genomic DNA Translation: ABU63192.1
EF605370 Genomic DNA Translation: ABU63198.1
EF605373 Genomic DNA Translation: ABU63201.1
EF605379 Genomic DNA Translation: ABU63207.1
EF605381 Genomic DNA Translation: ABU63209.1
EF605382 Genomic DNA Translation: ABU63210.1
EF605383 Genomic DNA Translation: ABU63211.1
EF605475 Genomic DNA Translation: ABU63254.1
EF605476 Genomic DNA Translation: ABU63255.1
EF605477 Genomic DNA Translation: ABU63256.1
EF605478 Genomic DNA Translation: ABU63257.1
EF605479 Genomic DNA Translation: ABU63258.1
EF605480 Genomic DNA Translation: ABU63259.1
EF605481 Genomic DNA Translation: ABU63260.1
EF605482 Genomic DNA Translation: ABU63261.1
EF605488 Genomic DNA Translation: ABU63267.1
EF605499 Genomic DNA Translation: ABU63278.1
EF605500 Genomic DNA Translation: ABU63279.1
EF605501 Genomic DNA Translation: ABU63280.1
EF605502 Genomic DNA Translation: ABU63281.1
EF605503 Genomic DNA Translation: ABU63282.1
EF605504 Genomic DNA Translation: ABU63283.1
EF605508 Genomic DNA Translation: ABU63287.1
GQ250376 Genomic DNA Translation: ACY03375.1
GQ250391 Genomic DNA Translation: ACY03390.1
LT548150 Genomic DNA Translation: SAI82194.1

NCBI Reference Sequences

More...
RefSeqi
NP_001188320.1, NM_001201391.1
NP_032246.2, NM_008220.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000023934; ENSMUSP00000023934; ENSMUSG00000052305
ENSMUST00000098192; ENSMUSP00000095794; ENSMUSG00000073940

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100503605
101488143

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:100503605
mmu:101488143

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131116 Genomic DNA No translation available.
EF605350 Genomic DNA Translation: ABU63178.1
EF605351 Genomic DNA Translation: ABU63179.1
EF605353 Genomic DNA Translation: ABU63181.1
EF605360 Genomic DNA Translation: ABU63188.1
EF605362 Genomic DNA Translation: ABU63190.1
EF605363 Genomic DNA Translation: ABU63191.1
EF605364 Genomic DNA Translation: ABU63192.1
EF605370 Genomic DNA Translation: ABU63198.1
EF605373 Genomic DNA Translation: ABU63201.1
EF605379 Genomic DNA Translation: ABU63207.1
EF605381 Genomic DNA Translation: ABU63209.1
EF605382 Genomic DNA Translation: ABU63210.1
EF605383 Genomic DNA Translation: ABU63211.1
EF605475 Genomic DNA Translation: ABU63254.1
EF605476 Genomic DNA Translation: ABU63255.1
EF605477 Genomic DNA Translation: ABU63256.1
EF605478 Genomic DNA Translation: ABU63257.1
EF605479 Genomic DNA Translation: ABU63258.1
EF605480 Genomic DNA Translation: ABU63259.1
EF605481 Genomic DNA Translation: ABU63260.1
EF605482 Genomic DNA Translation: ABU63261.1
EF605488 Genomic DNA Translation: ABU63267.1
EF605499 Genomic DNA Translation: ABU63278.1
EF605500 Genomic DNA Translation: ABU63279.1
EF605501 Genomic DNA Translation: ABU63280.1
EF605502 Genomic DNA Translation: ABU63281.1
EF605503 Genomic DNA Translation: ABU63282.1
EF605504 Genomic DNA Translation: ABU63283.1
EF605508 Genomic DNA Translation: ABU63287.1
GQ250376 Genomic DNA Translation: ACY03375.1
GQ250391 Genomic DNA Translation: ACY03390.1
LT548150 Genomic DNA Translation: SAI82194.1
RefSeqiNP_001188320.1, NM_001201391.1
NP_032246.2, NM_008220.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

CPTACinon-CPTAC-3546

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
15129

Genome annotation databases

EnsembliENSMUST00000023934; ENSMUSP00000023934; ENSMUSG00000052305
ENSMUST00000098192; ENSMUSP00000095794; ENSMUSG00000073940
GeneIDi100503605
101488143
KEGGimmu:100503605
mmu:101488143

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100503605
101488143
MGIiMGI:5474852 Hbb-bs
MGI:5474850 Hbb-bt

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00940000156216
KOiK13823
OMAiMVKWTEE
OrthoDBi1370439at2759
TreeFamiTF333268

Enzyme and pathway databases

ReactomeiR-MMU-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-MMU-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-MMU-2168880 Scavenging of heme from plasma
R-MMU-6798695 Neutrophil degranulation
R-MMU-9613829 Chaperone Mediated Autophagy
R-MMU-9615710 Microautophagy

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hbb-bs mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000052305 Expressed in 35 organ(s), highest expression level in spleen

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8DUK4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8DUK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: October 16, 2019
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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