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Entry version 115 (11 Dec 2019)
Sequence version 2 (29 Apr 2008)
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Protein

Genome polyprotein

Gene
N/A
Organism
Hepatitis C virus subtype 1a
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei952For protease NS2-3 activity; shared with dimeric partnerPROSITE-ProRule annotation1
Active sitei972For protease NS2-3 activity; shared with dimeric partnerPROSITE-ProRule annotation1
Active sitei993For protease NS2-3 activity; shared with dimeric partnerPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1123ZincCombined sources1
Metal bindingi1125ZincCombined sources1
Metal bindingi1171ZincCombined sources1
Metal bindingi1175Zinc; via pros nitrogenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Thiol proteasePROSITE-ProRule annotation, Transferase
Biological processActivation of host autophagy by virusSAAS annotation, Host-virus interaction, Inhibition of host innate immune response by virusSAAS annotation, Viral attachment to host cellSAAS annotation, Viral immunoevasion, Viral RNA replicationSAAS annotation, Virus entry into host cell
LigandATP-binding, Metal-bindingCombined sources, Nucleotide-binding, ZincCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHepatitis C virus subtype 1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri31646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaFlaviviridaeHepacivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000159290 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei718 – 739HelicalSequence analysisAdd BLAST22
Transmembranei759 – 778HelicalSequence analysisAdd BLAST20
Transmembranei785 – 802HelicalSequence analysisAdd BLAST18
Transmembranei814 – 835HelicalSequence analysisAdd BLAST22
Transmembranei873 – 901HelicalSequence analysisAdd BLAST29
Transmembranei1660 – 1688HelicalSequence analysisAdd BLAST29
Transmembranei1816 – 1840HelicalSequence analysisAdd BLAST25
Transmembranei1847 – 1870HelicalSequence analysisAdd BLAST24
Transmembranei1882 – 1902HelicalSequence analysisAdd BLAST21
Transmembranei2991 – 3008HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1123 ↔ 1125Combined sources

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1026 – 1027Cleavage; by protease NS2-3PROSITE-ProRule annotation2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8DG50

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
A8DG50

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini899 – 1026Peptidase C18InterPro annotationAdd BLAST128
Domaini1027 – 1208Peptidase S29InterPro annotationAdd BLAST182
Domaini1217 – 1369Helicase ATP-bindingInterPro annotationAdd BLAST153
Domaini1361 – 1538Helicase C-terminalInterPro annotationAdd BLAST178
Domaini2634 – 2752RdRp catalyticInterPro annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 77DisorderedSequence analysisAdd BLAST77
Regioni2187 – 2218DisorderedSequence analysisAdd BLAST32
Regioni2311 – 2334DisorderedSequence analysisAdd BLAST24
Regioni2351 – 2409DisorderedSequence analysisAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2488 – 2508Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 69PolyampholyteSequence analysisAdd BLAST23
Compositional biasi2195 – 2217PolarSequence analysisAdd BLAST23
Compositional biasi2311 – 2329Pro-richSequence analysisAdd BLAST19
Compositional biasi2351 – 2374PolarSequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1280.150, 1 hit
2.20.25.210, 1 hit
2.20.25.220, 1 hit
2.30.30.710, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011492 DEAD_Flavivir
IPR002521 HCV_core_C
IPR002522 HCV_core_N
IPR002519 HCV_env
IPR002531 HCV_NS1
IPR002518 HCV_NS2
IPR042205 HCV_NS2_C
IPR042209 HCV_NS2_N
IPR000745 HCV_NS4a
IPR001490 HCV_NS4b
IPR002868 HCV_NS5a
IPR013193 HCV_NS5a_1B_dom
IPR038568 HCV_NS5A_1B_sf
IPR024350 HCV_NS5a_C
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR013192 NS5A_1a
IPR038170 NS5A_1a_sf
IPR027417 P-loop_NTPase
IPR009003 Peptidase_S1_PA
IPR004109 Peptidase_S29_NS3
IPR007094 RNA-dir_pol_PSvirus
IPR002166 RNA_pol_HCV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07652 Flavi_DEAD, 1 hit
PF01543 HCV_capsid, 1 hit
PF01542 HCV_core, 1 hit
PF01539 HCV_env, 1 hit
PF01560 HCV_NS1, 1 hit
PF01538 HCV_NS2, 1 hit
PF01006 HCV_NS4a, 1 hit
PF01001 HCV_NS4b, 1 hit
PF01506 HCV_NS5a, 1 hit
PF08300 HCV_NS5a_1a, 1 hit
PF08301 HCV_NS5a_1b, 1 hit
PF12941 HCV_NS5a_C, 1 hit
PF02907 Peptidase_S29, 1 hit
PF00998 RdRP_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51693 HCV_NS2_PRO, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51822 HV_PV_NS3_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A8DG50-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTNPKPQRK TKRNTNRRPQ DVKFPGGGQI VGGVYLLPRR GPRLGVRATR
60 70 80 90 100
KTSERSQPRG RRQPIPKARR PEGRTWAQPG YPWPLYGNEG CGWAGWLLSP
110 120 130 140 150
RGSRPSWGPT DPRRRSRNLG KVIDTLTCGF ADLMGYIPLV GAPLGGAARA
160 170 180 190 200
LAHGVRVLED GVNYATGNLP GCSFSIFLLA LLSCLTVPAS AYQVRNSSGL
210 220 230 240 250
YHVTNDCPNS SIVYEAPDAI LHTPGCVPCV REGNTSRCWV AMTPTVATKD
260 270 280 290 300
GKLPTTQLRR HIDLLVGSAT LCSALYVGDL CGSVFLVGQL FTFSPKHHWT
310 320 330 340 350
TQDCNCSIYP GHITGHRMAW DMMMNWSPTA ALVMAQLLRI PQAILDMIAG
360 370 380 390 400
AHWGVLAGIA YFSMVGNWAK VLVVLLLFAS VDAQTYVTGG SAGRAALGFT
410 420 430 440 450
TFLSPGPKQN IQLVNTNGSW HINSTALNCN ESLDTGWLAG LFYYNRFNSS
460 470 480 490 500
GCRNRLASCR LLTDFDQGWG PISHANGSGP DQRPYCWHYP PKPCGIVSAK
510 520 530 540 550
TVCGPVYCFT PSPVAVGTTD KSGVPTYNWG ANETDVFVLN STRPPQGSWF
560 570 580 590 600
GCTWMNSTGF TKVCGAPPCA IGGTGNNTLH CPTDCFRKHP ETTYSRCGSG
610 620 630 640 650
PWLTPRCLVH YPYRLWHYPC TINYTIFKVR MYVGGVEHRL EAACNWTRGE
660 670 680 690 700
PCGLEDRDRT ELSPLLLSTT QWQVLPCSFT TLPALSTGLI HLHQNIVDVQ
710 720 730 740 750
YLYGVGSSIA SWAIKWEYVV LLFLLLADAR VCSCLWMMLL ISQAEAALEN
760 770 780 790 800
LVTLNAASLA GTHGPVPFLV FFCFAWYLKG RWVPGAVYAL YGMWPLLLLL
810 820 830 840 850
LALPQRAYAL DTEVAASCGG VVLVGLVALT LSPYYKRYIS WCLWWLQYFL
860 870 880 890 900
TRVEAQLHVW VPPLNVRGGR DAVILLMCVA HPILVFDITK LLLAVFGPLW
910 920 930 940 950
ILQASLLKVP YFVRVQGLLR ICALARKMAG GHYVQMAIIK LGALTGTYIY
960 970 980 990 1000
NHLTPLRDWA HNGLQDLAVA VEPVVFSPME TKLITWGADT AACGDIINGL
1010 1020 1030 1040 1050
PVSARRGQEI LLGPADGVVS KGWRLLAPIT AYAQQTRGLL GCIITSLTGR
1060 1070 1080 1090 1100
DKNQVEGEVQ IVSTAAQTFL ATCINGVCWT VYHGAGTRTI ASPKGPVIQM
1110 1120 1130 1140 1150
YTNVDKDLVG WPAPQGSRSL TPCTCGSSDL YLVTRHADVI PVRRRGDSRG
1160 1170 1180 1190 1200
SLLSPRPISY LKGSSGGPLL CPAGHAVGIF RAAVCTRGVA KAVDFIPVES
1210 1220 1230 1240 1250
LETTMRSPVF TDNSSPPAVP QSFQVTHLHA PTGSGKSTKV PAAYAAQGYK
1260 1270 1280 1290 1300
VLVLNPSVAA TLGFGAYMSK AHGIDPNIRT GVRTITTGSP ITYSTYGKFL
1310 1320 1330 1340 1350
ADGGCSGGAY DIIICDECHS TDATSILGIG TVLDQAETAG ARLVVLATAT
1360 1370 1380 1390 1400
PPGSVTVPHP NIEEVALSTT GEIPFYGKAI PLEVIKGGRH LIFCHSKRKC
1410 1420 1430 1440 1450
DELAAKLAAL GINAVAYYRG LDVSVIPTSG DVVVVATDAL MTGFTGDFDS
1460 1470 1480 1490 1500
VIDCNTCVTQ TVDFSLDPTF TIETTTLPQD AVSRTQRRGR TGRGKPGIYR
1510 1520 1530 1540 1550
FVAPGERPSG MFDSSVLCEC YDAGCAWYEL TPAETTVRLR AYMNTPGLPV
1560 1570 1580 1590 1600
CQDHLEFWEG VFTGLTHIDA HFLSQTKQSG ESLPYLVAYQ ATVCARAQAP
1610 1620 1630 1640 1650
PPSWDQMWKC LVRLKPTLHG PTPLLYRLGA VQNEVTLTHP ITKYIMTCMS
1660 1670 1680 1690 1700
ADLEVVTSTW VLVGGVLAAL AAYCLSTGCV VIVGRVILSG KPAIIPDREV
1710 1720 1730 1740 1750
LYREFDEMEE CSQHLPYIEQ GMMLAEQFKQ KALGLLQTAS RQAEVIAPAV
1760 1770 1780 1790 1800
QTNWQKLEAF WAKHMWNFIS GIQYLAGLST LPGNPAIASL MAFTAAVTSP
1810 1820 1830 1840 1850
LTTSQTLLFN ILGGWVAAQL AAPGAATAFV GAGLAGAAIG SVGLGKVLVD
1860 1870 1880 1890 1900
ILAGYGAGVA GALVAFKIMS GEVPSTEDLV NLLPAILSPG ALVVGVVCAA
1910 1920 1930 1940 1950
ILRRHVGPGE GAVQWMNRLI AFASRGNHVS PTHYVPESDA AARVTAILSS
1960 1970 1980 1990 2000
LTVTQLLRRL HQWISSECTT PCSGSWLRDI WDWICEVLSD FKTWLKAKLV
2010 2020 2030 2040 2050
PQLPGIPFVS CQRGYRGIWR GDGIMHTRCH CGAEISGHVR NGTMRIVGPR
2060 2070 2080 2090 2100
TCRNMWSGTF PINAYTTGPC TPLPAPNYKF ALWRVSAEEY VEIRQVGDFH
2110 2120 2130 2140 2150
YVTGMTTDNL KCPCQVPSPE FFTELDGVRL HRYAPPCKPL LREEVSFRVG
2160 2170 2180 2190 2200
LHEYPVGSQL PCEPEPDVAV LTSMLTDPSH ITAEAAGRRL ARGSPPSEAS
2210 2220 2230 2240 2250
SSASQLSAPS LKATCSANHD SPDAELIEAN LLWWQEMGGN ITRVESENKV
2260 2270 2280 2290 2300
VILDSFEPLV AKEDEREISV PAEILRKSRR FAQALPIWAR PDYNPPLIEA
2310 2320 2330 2340 2350
WKQPDYEPPV VHGCPLPPPQ SPPVPPPRKK RTVVLTESTL STALAELATK
2360 2370 2380 2390 2400
SFGSSSTSGI TGDNTTTSSE PAPSGCPPDS DAESYSSMPP LEGEPGDPDL
2410 2420 2430 2440 2450
SDGSWSTVSG EAGTEDVVCC SMSYSWTGAL ITPCAAEEQK LPINALSNSL
2460 2470 2480 2490 2500
LRHHNLVYST TSRSACQRQK KVTFDRLQVL DSHYQDVLKE VKAAASKVKA
2510 2520 2530 2540 2550
NLLSVEEACS LTPPHSAKSK FGYGAKDVRC HARKAVNHIN SVWKDLLEDS
2560 2570 2580 2590 2600
VTPIDTTIMA KNEVFCVQPE KGGRKPARLI VFPDLGVRVC EKMALYDVVT
2610 2620 2630 2640 2650
KLPLAVMGSS YGFQYSPGQR VEFLVQAWKS KKTPMGFSYD TRCFDSTVTE
2660 2670 2680 2690 2700
SDIRTEEAIY QCCDLDPQAR VAIKSLTERL YVGGPLTNSR GENCGYRRCR
2710 2720 2730 2740 2750
ASGVLTTSCG NTLTCYIKAR AACRAAGLQD CTMLVCGDDL VVICESAGVQ
2760 2770 2780 2790 2800
EDAASLRAFT EAMTRYSAPP GDPPQPEYDL ELITSCSSNV SVAHDGAGKR
2810 2820 2830 2840 2850
VYYLTRDPTT PLARAAWETA RHTPVNSWLG NIIMFAPTLW ARMILMTHFF
2860 2870 2880 2890 2900
SVLIARDQLE QALDCEIYGA CYSIEPLDLP PIIQRLHGLS AFSLHSYSPG
2910 2920 2930 2940 2950
EINRVAACLR KLGVPPLRAW RHRARNVRAR LLSRGGRAAI CGKYLFNWAV
2960 2970 2980 2990 3000
RTKLKLTPIA AAGQLDLSGW FTAGYSGGDI YHSVSHARPR WFWFCLLLLA
3010
AGVGIYLLPN R
Length:3,011
Mass (Da):326,965
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43B25306EA8F2918
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU155285 Genomic RNA Translation: ABV46162.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU155285 Genomic RNA Translation: ABV46162.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M5LX-ray1.25A1013-1208[»]
3M5MX-ray1.70A/B1013-1208[»]
3M5NX-ray1.90A/B/C/D1007-1007[»]
A/B/C/D1013-1208[»]
3M5OX-ray1.60A/B1013-1208[»]
3RC6X-ray1.30A1013-1208[»]
3SU0X-ray1.16A1013-1206[»]
3SU1X-ray1.40A1013-1208[»]
3SU2X-ray1.50A1013-1208[»]
3SU3X-ray1.30A1013-1208[»]
3SU5X-ray1.55A1013-1208[»]
3SU6X-ray1.10A1013-1208[»]
3SUDX-ray1.96A/B/C/D1013-1208[»]
3SUEX-ray2.20A/B/C/D1013-1208[»]
3SUFX-ray2.19A/B/C/D1013-1208[»]
3SUGX-ray1.80A1013-1208[»]
3SV6X-ray1.40A1013-1208[»]
3SV7X-ray1.55A1013-1208[»]
3SV8X-ray2.50A1013-1208[»]
3SV9X-ray1.60A1013-1208[»]
4NWKX-ray1.62A1013-1026[»]
A1031-1208[»]
4NWLX-ray2.20A/B1013-1026[»]
A/B1031-1208[»]
4WH6X-ray1.99A1030-1206[»]
4WH8X-ray2.70A/B1030-1205[»]
6C2NX-ray1.80A1013-1026[»]
A1029-1208[»]
SMRiA8DG50
ModBaseiSearch...
PDBe-KBiSearch...

Miscellaneous databases

EvolutionaryTraceiA8DG50

Family and domain databases

Gene3Di1.20.1280.150, 1 hit
2.20.25.210, 1 hit
2.20.25.220, 1 hit
2.30.30.710, 1 hit
InterProiView protein in InterPro
IPR011492 DEAD_Flavivir
IPR002521 HCV_core_C
IPR002522 HCV_core_N
IPR002519 HCV_env
IPR002531 HCV_NS1
IPR002518 HCV_NS2
IPR042205 HCV_NS2_C
IPR042209 HCV_NS2_N
IPR000745 HCV_NS4a
IPR001490 HCV_NS4b
IPR002868 HCV_NS5a
IPR013193 HCV_NS5a_1B_dom
IPR038568 HCV_NS5A_1B_sf
IPR024350 HCV_NS5a_C
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR013192 NS5A_1a
IPR038170 NS5A_1a_sf
IPR027417 P-loop_NTPase
IPR009003 Peptidase_S1_PA
IPR004109 Peptidase_S29_NS3
IPR007094 RNA-dir_pol_PSvirus
IPR002166 RNA_pol_HCV
PfamiView protein in Pfam
PF07652 Flavi_DEAD, 1 hit
PF01543 HCV_capsid, 1 hit
PF01542 HCV_core, 1 hit
PF01539 HCV_env, 1 hit
PF01560 HCV_NS1, 1 hit
PF01538 HCV_NS2, 1 hit
PF01006 HCV_NS4a, 1 hit
PF01001 HCV_NS4b, 1 hit
PF01506 HCV_NS5a, 1 hit
PF08300 HCV_NS5a_1a, 1 hit
PF08301 HCV_NS5a_1b, 1 hit
PF12941 HCV_NS5a_C, 1 hit
PF02907 Peptidase_S29, 1 hit
PF00998 RdRP_3, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51693 HCV_NS2_PRO, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51822 HV_PV_NS3_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8DG50_9HEPC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8DG50
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: April 29, 2008
Last modified: December 11, 2019
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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