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Protein

LIM and senescent cell antigen-like-containing domain protein

Gene

Lims1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and senescent cell antigen-like-containing domain proteinUniRule annotation
Gene namesi
Name:Lims1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1195263 Lims1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junctionUniRule annotation, Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 69LIM zinc-bindingInterPro annotationAdd BLAST62
Domaini71 – 128LIM zinc-bindingInterPro annotationAdd BLAST58
Domaini133 – 190LIM zinc-bindingInterPro annotationAdd BLAST58
Domaini191 – 250LIM zinc-bindingInterPro annotationAdd BLAST60
Domaini251 – 310LIM zinc-bindingInterPro annotationAdd BLAST60

Keywords - Domaini

LIM domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2272 Eukaryota
ENOG410XP46 LUCA
HOVERGENiHBG000053

Family and domain databases

InterProiView protein in InterPro
IPR017351 PINCH
IPR001781 Znf_LIM
PANTHERiPTHR24210 PTHR24210, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 5 hits
PIRSFiPIRSF038003 PINCH, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 5 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

A8CVP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF
60 70 80 90 100
YEFEGRKYCE HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC
110 120 130 140 150
QEVLADIGFV KNAGRHLCRP CHNREKARGL GKYICQKCHA IIDEQPLIFK
160 170 180 190 200
NDPYHPDHFN CANCGKELTA DARELKGELY CLPCHDKMGV PICGACRRPI
210 220 230 240 250
EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC ETHYNQLFGD
260 270 280 290 300
VCFHCNRVIE GDVVSALNKA WCVSCFACST CNTKLTLKNK FVEFDMKPVC
310 320
KECYEKFPLE LKKRLKKLSE TLGRK
Length:325
Mass (Da):37,241
Last modified:November 13, 2007 - v1
Checksum:iE68BFEA59B5FFDF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU122954 mRNA Translation: ABV30674.1
UniGeneiMm.402697
Mm.482932
Mm.57734

Similar proteinsi

Entry informationi

Entry nameiA8CVP4_MOUSE
AccessioniPrimary (citable) accession number: A8CVP4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: January 31, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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