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Protein

Probable spanin, outer lipoprotein subunit

Gene

Rz1

Organism
Salmonella phage P22 (Bacteriophage P22)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the spanin complex that disrupts the host outer membrane and participates in cell lysis during virus exit. The spanin complex conducts the final step in host lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans. Host outer membrane disruption is possibly due to local fusion between the inner and outer membrane performed by the spanin complex (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCytolysis, Host cell lysis by virus, Viral release from host cell

Protein family/group databases

TCDBi1.M.1.1.4 the rz/rz1 spanin1 (rz(1)) family

Names & Taxonomyi

Protein namesi
Recommended name:
Probable spanin, outer lipoprotein subunit
Short name:
o-spanin
Alternative name(s):
Rz1 protein
Gene namesi
Name:Rz1
OrganismiSalmonella phage P22 (Bacteriophage P22)
Taxonomic identifieri10754 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeP22virus
Virus hostiSalmonella typhimurium [TaxID: 90371]
Proteomesi
  • UP000002165 Componenti: Genome
  • UP000001795 Componenti: Genome
  • UP000001796 Componenti: Genome
  • UP000001315 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 61PeriplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

Keywords - Cellular componenti

Host cell outer membrane, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000042926129 – 61Probable spanin, outer lipoprotein subunitAdd BLAST33

Keywords - PTMi

Lipoprotein

Interactioni

Subunit structurei

Interacts (via C-terminus) with the spanin inner membrane subunit (via C-terminus). Part of the spanin complex which spans the entire periplasmic space. The spanin complex is composed of spanin inner membrane subunit and spanin outer membrane subunit (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the caudovirales o-spanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiVOG09000244

Family and domain databases

InterProiView protein in InterPro
IPR010346 o-spanin
PfamiView protein in Pfam
PF06085 Rz1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8CGF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTRLSKLSA LMFLLGVSAC KSPPPVQSQR PEPAAWAMEK AQDLQQMLNS
60
IITVSEVEST G
Length:61
Mass (Da):6,617
Last modified:November 13, 2007 - v1
Checksum:i2C30817CC6B76A7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK000583 Genomic DNA Translation: DAA01048.1
AF527608 Genomic DNA Translation: AAM81450.1
AB362338 Genomic DNA Translation: BAF80782.1
AB426868 Genomic DNA Translation: BAG12665.1
RefSeqiYP_063732.1, NC_002371.2

Genome annotation databases

GeneIDi2944226
KEGGivg:2944226

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK000583 Genomic DNA Translation: DAA01048.1
AF527608 Genomic DNA Translation: AAM81450.1
AB362338 Genomic DNA Translation: BAF80782.1
AB426868 Genomic DNA Translation: BAG12665.1
RefSeqiYP_063732.1, NC_002371.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.M.1.1.4 the rz/rz1 spanin1 (rz(1)) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2944226
KEGGivg:2944226

Phylogenomic databases

OrthoDBiVOG09000244

Family and domain databases

InterProiView protein in InterPro
IPR010346 o-spanin
PfamiView protein in Pfam
PF06085 Rz1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPAN2_BPP22
AccessioniPrimary (citable) accession number: A8CGF6
Secondary accession number(s): Q8LTE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 14, 2014
Last sequence update: November 13, 2007
Last modified: January 31, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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