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Protein

Thyroid adenoma-associated protein homolog

Gene

Thada

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid adenoma-associated protein homolog
Gene namesi
Name:Thada
Synonyms:Kiaa1767
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3039623 Thada

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003440581 – 1938Thyroid adenoma-associated protein homologAdd BLAST1938

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1006PhosphoserineCombined sources1
Modified residuei1015PhosphoserineBy similarity1
Modified residuei1152PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA8C756
MaxQBiA8C756
PaxDbiA8C756
PeptideAtlasiA8C756
PRIDEiA8C756

PTM databases

iPTMnetiA8C756
PhosphoSitePlusiA8C756
SwissPalmiA8C756

Expressioni

Gene expression databases

BgeeiENSMUSG00000024251 Expressed in 192 organ(s), highest expression level in dorsal pancreas
GenevisibleiA8C756 MM

Interactioni

Protein-protein interaction databases

BioGridi232178, 2 interactors
IntActiA8C756, 1 interactor
STRINGi10090.ENSMUSP00000041701

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili877 – 909Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi943 – 946Poly-Leu4
Compositional biasi1313 – 1318Poly-Leu6
Compositional biasi1581 – 1584Poly-Leu4

Sequence similaritiesi

Belongs to the THADA family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1810 Eukaryota
COG5543 LUCA
GeneTreeiENSGT00390000015500
HOGENOMiHOG000078273
HOVERGENiHBG108565
InParanoidiA8C756
OMAiWQSMCGL
OrthoDBiEOG091G084B
PhylomeDBiA8C756
TreeFamiTF319713

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR019442 DUF2428_death-receptor-like
PfamiView protein in Pfam
PF10350 DUF2428, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A8C756-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVKKKREMQ VAALTVCHQD METLRSFADM EGKNLASLLL HCVQLTDGVS
60 70 80 90 100
QIHSIKQIVP LLEKVDKNGV CDPAIQSCLD ILAGIYFSLT LKNPLKKVLA
110 120 130 140 150
SSLNGLPEVF LTQATHSFTF HLQEELDTAD LYSYRKVMDN ISSCMENFNL
160 170 180 190 200
GRASVVNLLK DVLHFLQKSL IEILEENRKF AGNRIVQTQL MSDLLVGVRV
210 220 230 240 250
AMTLVQKVQG PQGSLWNDSS SPIWQSMCGL LSIFTKFLND DDLLQTVEST
260 270 280 290 300
SGLAVILFIK TMFRPSEKLP GLISSLLLRS AECTSIPEWL MNSCRSLCCT
310 320 330 340 350
DVPASTLLFL CQGTLAMLDW QDGSMGPSGE ALLLDIVHVL FTLSSQIKES
360 370 380 390 400
TLDMFLSRIL ASWTSSAIQI LESGSSGLKG HLNGDSCVPR RLLEYVYTHW
410 420 430 440 450
EHPLDALRHQ TKVMFRNLLQ MHRLTMEGAD LATDPFCLEL TKSLLQLEWH
460 470 480 490 500
IKGKYACLGC LVETLGIEHI LAIDKTIPSQ ILEVMGDQSL VPYASDLLET
510 520 530 540 550
MFKNHKSHLK SQTVTNTWMD KWHETWVFPV LSVLCGGNLD QRSYVIDYYL
560 570 580 590 600
PRILNYSPES LHYMVHILQA STDTGTGSCN HRGALGALMA CLRTARAHGH
610 620 630 640 650
LQSATQAWEN LVCSARVKQG LIHQHCQVRI DTLGLLCESN RSTEVVSTEE
660 670 680 690 700
MQWVQFFITY NLNSQSPGVR QQICSLLKKL FCRIQESSQV LYKLEQRKST
710 720 730 740 750
PDSENGSIRE QPSVTLQQYK NFMSSVCNIL FEALFPGSSY STRFSALTIL
760 770 780 790 800
GSVAEVFPDP EGNIQTVYQL SHDIDAGRYQ ILMECFTSTF EEVKTLAFDL
810 820 830 840 850
LMKLSSVTAG QFQDSEKLQD LFQAALELST STKPYDCVTA SYLLNLLIRQ
860 870 880 890 900
DALPAVLSAS SPQQLTRGAG ETSAVLERNT LVVIKCLMEN LEDEISQAEN
910 920 930 940 950
SLLQAASSFP MYGRVHCITR AFQRLPLNDL RLASEWRPLL GRLLLLSYRL
960 970 980 990 1000
STVVAPVIQS SSPEGLIPVD TDSASASRLQ LILNEIQPRD TNDYFNHTKI
1010 1020 1030 1040 1050
LKECDSFDLE DLSTSVSNID SSAEVKGKEE KACDVTAQMV LACCWRSMKE
1060 1070 1080 1090 1100
VALLLGTLCQ LLPVQPGPES SNVFLTVQQV KEIGDYFKQH LLQSRHRGAF
1110 1120 1130 1140 1150
ELAYTGFVKL TEILNRCSNV SLQKLPEQWL RSVLEEIKGS DPSSKLCATR
1160 1170 1180 1190 1200
RSAGIPFYIQ ALLASEPKKS RMDLLKITMR ELISLALSAD DSKGRVPQVH
1210 1220 1230 1240 1250
ALNILRALFR DTRLGENIIP YVAGGAKAAI LGFTSPVWAV RNSSTLLFSS
1260 1270 1280 1290 1300
LITRVFGVKR GKDEVSKTNR MTGREFFSRF PELYPFLLKQ LETVASTVDS
1310 1320 1330 1340 1350
ELGEPDRHPG MFLLLLVLER LYPSPMDGTS SALSLAPFVP FIIRCGRSPI
1360 1370 1380 1390 1400
YRSREMAARA LVPFIMIDQI PSTLCALLNS LPNSTDQCFR QNHIHGTLLQ
1410 1420 1430 1440 1450
VFHLLQAYIT DCRHRTNADF LQELSDVTAC TKAKLWLAMR QNPCLVTRAV
1460 1470 1480 1490 1500
YIDILFLLTN CLDRPEEGKQ TALESLGFWE DVRRIILESE LIKGFPWTFK
1510 1520 1530 1540 1550
VPGLPQYLQS LTKLAIPEVW ASLAEAKGQA TAVPLSFSRL LKSSFPEVRL
1560 1570 1580 1590 1600
LALDTLLERA RSSEQEQKEP LPLLCSMGEE LLLLAMKEDH PGCFCRVLKI
1610 1620 1630 1640 1650
LYHLNPSEWL PQTECYAHLS PKEFLMWSMD IASNDRSEIQ GVALKLASKI
1660 1670 1680 1690 1700
IAYRVQSCEK NKDSLAPELR QWVQLVVWSC GDHLPTASRL AVAEVLTSTA
1710 1720 1730 1740 1750
PLFLTSPQPI LELQGTLSLW RCVLTLLQSE EQTVREAATE IVTTAMSQGN
1760 1770 1780 1790 1800
TCQSTEFAFC QVDASIALTL ALAVLCDLLQ QWDQLEPGLP ILLGWLLEEG
1810 1820 1830 1840 1850
DDLEGHVQSP HQGEEEHIFE KSEVNFWAET LTFVKSLCRQ LFHLLCQSGW
1860 1870 1880 1890 1900
QSPHSQKLCH LQRIASEQSH LISQLFRELP LSAEFLKTVE YTRLRIQEER
1910 1920 1930
TLAVLRLLAC LEGKEGLRAE DCPREWRQVM APRTEAAC
Length:1,938
Mass (Da):217,289
Last modified:November 13, 2007 - v1
Checksum:iF1E09CC95E2A2B54
GO
Isoform 2 (identifier: A8C756-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1270: Missing.

Show »
Length:668
Mass (Da):75,674
Checksum:iB2AC92D667ECE12D
GO
Isoform 3 (identifier: A8C756-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1438: Missing.

Note: No experimental confirmation available.
Show »
Length:500
Mass (Da):56,646
Checksum:i78F416E93E0D8E18
GO
Isoform 4 (identifier: A8C756-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-347: I → V
     348-1938: Missing.

Note: No experimental confirmation available.
Show »
Length:347
Mass (Da):38,376
Checksum:i6A769CB239E9B999
GO
Isoform 5 (identifier: A8C756-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1576: Missing.

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):41,036
Checksum:i5A19E8B8FAFFBF9C
GO

Sequence cautioni

The sequence BAD32536 differs from that shown. Intron retention.Curated
The sequence BAE33129 differs from that shown. Reason: Erroneous termination at position 1897. Translated as Gln.Curated
The sequence BAE41536 differs from that shown. Reason: Frameshift at position 1917.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1749G → V in BAE33129 (PubMed:16141072).Curated1
Sequence conflicti1750N → S in AAH52885 (PubMed:15489334).Curated1
Sequence conflicti1759F → S in BAE33129 (PubMed:16141072).Curated1
Sequence conflicti1925E → G in BAE33129 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0347401 – 1576Missing in isoform 5. 1 PublicationAdd BLAST1576
Alternative sequenceiVSP_0347361 – 1438Missing in isoform 3. 1 PublicationAdd BLAST1438
Alternative sequenceiVSP_0347371 – 1270Missing in isoform 2. 1 PublicationAdd BLAST1270
Alternative sequenceiVSP_034738347I → V in isoform 4. 1 Publication1
Alternative sequenceiVSP_034739348 – 1938Missing in isoform 4. 1 PublicationAdd BLAST1591

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF222207 mRNA Translation: ABQ10601.1
AK044550 mRNA Translation: BAC31976.1
AK155218 mRNA Translation: BAE33129.1 Sequence problems.
AK170056 mRNA Translation: BAE41536.1 Frameshift.
BC052885 mRNA Translation: AAH52885.1
AK173258 mRNA Translation: BAD32536.1 Sequence problems.
CCDSiCCDS50198.1 [A8C756-1]
RefSeqiNP_898842.2, NM_183021.3 [A8C756-1]
XP_006524337.2, XM_006524274.3 [A8C756-1]
XP_006524339.1, XM_006524276.3 [A8C756-1]
XP_017172962.1, XM_017317473.1 [A8C756-1]
UniGeneiMm.246767

Genome annotation databases

EnsembliENSMUST00000047524; ENSMUSP00000041701; ENSMUSG00000024251 [A8C756-1]
GeneIDi240174
KEGGimmu:240174
UCSCiuc008dsr.2 mouse [A8C756-3]
uc008dss.2 mouse [A8C756-2]
uc012axy.1 mouse [A8C756-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF222207 mRNA Translation: ABQ10601.1
AK044550 mRNA Translation: BAC31976.1
AK155218 mRNA Translation: BAE33129.1 Sequence problems.
AK170056 mRNA Translation: BAE41536.1 Frameshift.
BC052885 mRNA Translation: AAH52885.1
AK173258 mRNA Translation: BAD32536.1 Sequence problems.
CCDSiCCDS50198.1 [A8C756-1]
RefSeqiNP_898842.2, NM_183021.3 [A8C756-1]
XP_006524337.2, XM_006524274.3 [A8C756-1]
XP_006524339.1, XM_006524276.3 [A8C756-1]
XP_017172962.1, XM_017317473.1 [A8C756-1]
UniGeneiMm.246767

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232178, 2 interactors
IntActiA8C756, 1 interactor
STRINGi10090.ENSMUSP00000041701

PTM databases

iPTMnetiA8C756
PhosphoSitePlusiA8C756
SwissPalmiA8C756

Proteomic databases

EPDiA8C756
MaxQBiA8C756
PaxDbiA8C756
PeptideAtlasiA8C756
PRIDEiA8C756

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047524; ENSMUSP00000041701; ENSMUSG00000024251 [A8C756-1]
GeneIDi240174
KEGGimmu:240174
UCSCiuc008dsr.2 mouse [A8C756-3]
uc008dss.2 mouse [A8C756-2]
uc012axy.1 mouse [A8C756-1]

Organism-specific databases

CTDi63892
MGIiMGI:3039623 Thada
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1810 Eukaryota
COG5543 LUCA
GeneTreeiENSGT00390000015500
HOGENOMiHOG000078273
HOVERGENiHBG108565
InParanoidiA8C756
OMAiWQSMCGL
OrthoDBiEOG091G084B
PhylomeDBiA8C756
TreeFamiTF319713

Miscellaneous databases

ChiTaRSiThada mouse
PROiPR:A8C756
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024251 Expressed in 192 organ(s), highest expression level in dorsal pancreas
GenevisibleiA8C756 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR019442 DUF2428_death-receptor-like
PfamiView protein in Pfam
PF10350 DUF2428, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTHADA_MOUSE
AccessioniPrimary (citable) accession number: A8C756
Secondary accession number(s): Q3TDR4
, Q3U2L1, Q69ZA8, Q7TPV7, Q8C8S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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