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Entry version 66 (11 Dec 2019)
Sequence version 1 (13 Nov 2007)
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Protein

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase

Gene

GL50803_12081

Organism
Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5.8 µM for UDP-GlcNAc1 Publication
  1. Vmax=5.1 pmol/min/mg enzyme1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1269UDPBy similarity1
Binding sitei1272UDPBy similarity1
Binding sitei1357UDPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1333 – 1336UDPBy similarity4
Nucleotide bindingi1351 – 1353UDPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT41 Glycosyltransferase Family 41

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase (EC:2.4.1.2551 Publication)
Short name:
GlOGT1 Publication
Alternative name(s):
O-linked GlcNAc transferaseImported
O-linked N-acetylglucosaminyltransferase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:GL50803_12081
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGiardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri184922 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetamonadaDiplomonadidaHexamitidaeGiardiinaeGiardia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
GiardiaDB:GL50803_12081

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004169391 – 1480UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferaseAdd BLAST1480

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A8BFN4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati38 – 71TPR 1Sequence analysisAdd BLAST34
Repeati113 – 146TPR 2Sequence analysisAdd BLAST34
Repeati176 – 209TPR 3Sequence analysisAdd BLAST34
Repeati288 – 321TPR 4Sequence analysisAdd BLAST34
Repeati613 – 646TPR 5Sequence analysisAdd BLAST34
Repeati648 – 680TPR 6Sequence analysisAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TPR repeat domain is required for substrate binding and oligomerization.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4626 Eukaryota
ENOG410ZUK7 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8BFN4

KEGG Orthology (KO)

More...
KOi
K09667

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDDINSI

Database of Orthologous Groups

More...
OrthoDBi
142546at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037919 OGT
IPR029489 OGT/SEC/SPY_C
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR44366 PTHR44366, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13844 Glyco_transf_41, 2 hits
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8BFN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVALMDKIAQ LFRNKQYSDL IQLIDKQLHA KNEPEALIFL YAIQGEISFK
60 70 80 90 100
QKDWIQAFAA YEKAVAESKQ KGLPTQVYAQ IVQRQMIILL RLQMLDTAFG
110 120 130 140 150
LFSENQSVSV DNVQVLAQLA LLYLMCERYS EAEKLLSSIV ESSTSNTITL
160 170 180 190 200
SKQFKEDIGP FKELFGVLDT YDTFLATILN NLAICNSKLG NHTLAFDQFQ
210 220 230 240 250
QALDIIKDPE KITRPPLSPI TVLFDNCVST VDEDKEKALK VEHHMLTINE
260 270 280 290 300
SKENQEDDTV LSLLRDGCTL IPSSTLGTHL PLIIELHSTI CYNIGKLELT
310 320 330 340 350
LGNLDRSVNH FKKSIEYQPS FARYVALGLV YRDMRNFYDA AEMLTKAVDS
360 370 380 390 400
CVGISNLCLG EVVYNLGILV SEELKMPYKS LQFFDEATVL FIRGEFSAGA
410 420 430 440 450
ILSRIMKANS LTTITTATAV SSDWEFIMAF LNTLYLDLCA FSKDQGFNVE
460 470 480 490 500
AAFTGTNAIS FNLPITEPQE KESPKSDKIA SEKPLVESNP GRSRTPSSMN
510 520 530 540 550
DVYMLSAENL SFSLLESSFA QKETITSRLF PTFQAETKRY LAILYTNLGL
560 570 580 590 600
IYYRIGIPTY YKQARRCFEV AIWFDNDCVF AINYLSVLLL KENSKTLAIE
610 620 630 640 650
GLLKCTRLFP EYYEPFYNLG NILKADEENK KALQYYSRAI ELNPRFLDGY
660 670 680 690 700
LARGVLYAEL HRFETAYLDF SKCIELDPDN RHAFCNYIHM KQILGIFHND
710 720 730 740 750
TLDMRKISKI IDDYIHEYLT VQNAINKGVV LPSHPLPPIM PYHCYLYRLS
760 770 780 790 800
SSQLRFICQR YSEQNVNWVK QNIDMMSTPL LDLSIHQRPM PPSIGLINSV
810 820 830 840 850
SSSSQLQLSM LPLNQSAADS MVPLAMLTPG PTLCTAIGFQ SIKSVIRDSQ
860 870 880 890 900
HITHGPIFSY DRALITLARS KHSSKCPISY IDIVNLKSPL RLGVLCDDIN
910 920 930 940 950
SIPIGCILES WLRNIDPKVA SLSIYSTVAS DKSALRTSLE AHCSNFIDFT
960 970 980 990 1000
NYKYQNNPFL CAQRINGDGI CIMISMCQHN CGLEGRILAM RPAPIQISYW
1010 1020 1030 1040 1050
THGGTTNSNY LDYILADQYC IPPGYAHLYS EHVITMPGCF ICPSHSMHYS
1060 1070 1080 1090 1100
NAILLEEHAD ILKVTVEEVR SLIQDSKPDI DVNHHSAAGE NILSLDGSDA
1110 1120 1130 1140 1150
TSSSVDSGIG SRTHSEAPIG GGDKDEGAHS SKILELELEL AEIAKMKGET
1160 1170 1180 1190 1200
KNGVSTNSAS EGRDELLMND RILITGDNVF FQVQPIRNGR LVGGRDRSMI
1210 1220 1230 1240 1250
KKMEPLLKAI YPLQRIASEA AVPASMEKSE NNSDLTSHRV CLELPLYRKN
1260 1270 1280 1290 1300
IRALYGIPAN CFLFCTFNQV YKFDMGTLGI IAALLRSVPN AYYALLKFPP
1310 1320 1330 1340 1350
ASQLHIEAFF RHKAPDILDR VIFLSMLPMK VEHIRRYLAV DVFVDTLKCN
1360 1370 1380 1390 1400
GSTIVLDALW SGVPVVGFVG EYILSRKTLS FLSVLECKDL ICASQGEAVL
1410 1420 1430 1440 1450
LCTRLAVDSG YYFSVRKRIL KNRSNLFNIS RWCDNFVLTM MLAYKNWIFG
1460 1470 1480
GKPTSFSTER VIANVKSQGF SWPLKSTGAQ
Length:1,480
Mass (Da):166,363
Last modified:November 13, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1D3856F0EB6886F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AACB02000015 Genomic DNA Translation: EDO79630.1

NCBI Reference Sequences

More...
RefSeqi
XP_001707304.1, XM_001707252.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EDO79630; EDO79630; GL50803_12081

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5700203

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gla:GL50803_12081

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACB02000015 Genomic DNA Translation: EDO79630.1
RefSeqiXP_001707304.1, XM_001707252.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiGT41 Glycosyltransferase Family 41

Proteomic databases

PRIDEiA8BFN4

Genome annotation databases

EnsemblProtistsiEDO79630; EDO79630; GL50803_12081
GeneIDi5700203
KEGGigla:GL50803_12081

Organism-specific databases

EuPathDBiGiardiaDB:GL50803_12081

Phylogenomic databases

eggNOGiKOG4626 Eukaryota
ENOG410ZUK7 LUCA
InParanoidiA8BFN4
KOiK09667
OMAiCDDINSI
OrthoDBi142546at2759

Enzyme and pathway databases

UniPathwayiUPA00378

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR037919 OGT
IPR029489 OGT/SEC/SPY_C
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PANTHERiPTHR44366 PTHR44366, 1 hit
PfamiView protein in Pfam
PF13844 Glyco_transf_41, 2 hits
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 8 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOGT1_GIAIC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8BFN4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: November 13, 2007
Last modified: December 11, 2019
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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