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Entry version 84 (02 Dec 2020)
Sequence version 1 (13 Nov 2007)
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Protein
Submitted name:

Nuclear receptor co-repressor

Gene

ncor1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation, ReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear receptor co-repressorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ncor1Imported
Synonyms:ncorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040426-993, ncor1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A8B6H7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8B6H7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini423 – 474SANTInterPro annotationAdd BLAST52
Domaini637 – 688SANTInterPro annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 122DisorderedSequence analysisAdd BLAST122
Regioni142 – 165DisorderedSequence analysisAdd BLAST24
Regioni198 – 217DisorderedSequence analysisAdd BLAST20
Regioni479 – 647DisorderedSequence analysisAdd BLAST169
Regioni685 – 891DisorderedSequence analysisAdd BLAST207
Regioni947 – 977DisorderedSequence analysisAdd BLAST31
Regioni996 – 1040DisorderedSequence analysisAdd BLAST45
Regioni1430 – 1553DisorderedSequence analysisAdd BLAST124
Regioni1702 – 1765DisorderedSequence analysisAdd BLAST64
Regioni1822 – 1907DisorderedSequence analysisAdd BLAST86
Regioni1923 – 2019DisorderedSequence analysisAdd BLAST97
Regioni2035 – 2166DisorderedSequence analysisAdd BLAST132
Regioni2243 – 2409DisorderedSequence analysisAdd BLAST167

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili296 – 316Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 54PolarSequence analysisAdd BLAST54
Compositional biasi55 – 77PolyampholyteSequence analysisAdd BLAST23
Compositional biasi87 – 102PolyampholyteSequence analysisAdd BLAST16
Compositional biasi103 – 122PolarSequence analysisAdd BLAST20
Compositional biasi492 – 557PolyampholyteSequence analysisAdd BLAST66
Compositional biasi558 – 584PolarSequence analysisAdd BLAST27
Compositional biasi588 – 613Pro-richSequence analysisAdd BLAST26
Compositional biasi689 – 712PolyampholyteSequence analysisAdd BLAST24
Compositional biasi727 – 758PolarSequence analysisAdd BLAST32
Compositional biasi777 – 791PolyampholyteSequence analysisAdd BLAST15
Compositional biasi819 – 835PolarSequence analysisAdd BLAST17
Compositional biasi836 – 854PolyampholyteSequence analysisAdd BLAST19
Compositional biasi947 – 972PolyampholyteSequence analysisAdd BLAST26
Compositional biasi1016 – 1040PolarSequence analysisAdd BLAST25
Compositional biasi1440 – 1455PolarSequence analysisAdd BLAST16
Compositional biasi1469 – 1522PolarSequence analysisAdd BLAST54
Compositional biasi1702 – 1734PolyampholyteSequence analysisAdd BLAST33
Compositional biasi1747 – 1765PolarSequence analysisAdd BLAST19
Compositional biasi1823 – 1852PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1891 – 1905PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1935 – 1951PolarSequence analysisAdd BLAST17
Compositional biasi2035 – 2066PolarSequence analysisAdd BLAST32
Compositional biasi2079 – 2094PolarSequence analysisAdd BLAST16
Compositional biasi2095 – 2117PolyampholyteSequence analysisAdd BLAST23
Compositional biasi2244 – 2323PolarSequence analysisAdd BLAST80
Compositional biasi2333 – 2382PolarSequence analysisAdd BLAST50

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the N-CoR nuclear receptor corepressors family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
12227at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8B6H7

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00167, SANT, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR031557, N-CoR_GPS2_interact
IPR001005, SANT/Myb
IPR017884, SANT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15784, GPS2_interact, 1 hit
PF00249, Myb_DNA-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00717, SANT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51293, SANT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8B6H7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSGFPPSQ GSFSSEQSRY PPHSVQYTFS STRHPQEFSV SDYRNPLQDQ
60 70 80 90 100
QRRRPSLLSE FHPGTERPPE RKHGYEQQFH AISAQEEQEA LESKRPRIEN
110 120 130 140 150
VSETHFSRSQ PTSIILPSQH TLQDTIRTSA DVKKESQFGV KVEASSPGGV
160 170 180 190 200
PQVGEDADTS PSKLSKEELI QSMDRVDREI AKVEQQIFKL KKKQQQLEEE
210 220 230 240 250
AAKPVEPEKP VTPPPVEHKH RSIVQIIYDE NRKKAEEAHK ILEGLGPKVE
260 270 280 290 300
LPLYNQPSDT KVYHDNIKTN QVMRKKLILF FKRRNHARKQ REQKICQRYD
310 320 330 340 350
ELMTEWEKKV ERMENNPRRK AKESRTREYY ERQFPEIRKQ REQQERFQRV
360 370 380 390 400
GQRGTGLSAT IARSEHEISE IIDGLSEQEN NEKQMRQLSV IPPMMYDSEQ
410 420 430 440 450
RRVKFINMNG LMDDPMKVYK SRQFMNVWTE HEKEIFREKF VQHPKNFGLI
460 470 480 490 500
ASFLERKCVS DCVLYYYLTK KSQNYKTLVR RNFGNRRRRN QQITRPSQEE
510 520 530 540 550
KTEDKNEEDK SEKTEKKEDE EKKEEEEKDE KEDSKDISKD KENCEGEEEE
560 570 580 590 600
GKEQSTPRGR KTANSQGRRK GRITTRSMAN NEAASVVSED PPPPPPEPVL
610 620 630 640 650
PEPAPPSKPE PTQKPAREPA KPSIAASADT RGAVEAGETS RWTEEEMEIA
660 670 680 690 700
KKGLVEHGRN WSAIAKMVGS KSEAQCKNFY FNNKRRYNLD NLLRQHKGSR
710 720 730 740 750
RLRGNRDPSQ SDPVPDDDEE SDGPDNSSDT ESAPSPTQTD PSKPSESLTH
760 770 780 790 800
TISAVDGGSD QDVTAAKGPV ADAKGQESPY DELKVKIEKS PEGGAGDVLP
810 820 830 840 850
QDDRARSAYE MQIHPKSEPQ DVEMTSPSTD RAQVQVKTEP EVKDKEERQG
860 870 880 890 900
EQQHSDNDSS ATCSADEDVE AEPDRQRMYS LEKPSLLGPS GSVVVSSAKL
910 920 930 940 950
LNMQQMQQRA ATIPPMVSAP FGHSGVPGGP MSGFAMFQHQ IKAVHESVQE
960 970 980 990 1000
DKQRLDQNES DRRTRVTTHS PTVLDREGKP FAYMPYDLKL MEQEALGGAG
1010 1020 1030 1040 1050
RPGSPYRLSP REPSKASPQP DGSNSARYSV PPVLQPAPNQ AVQTVSDVRM
1060 1070 1080 1090 1100
TFSRHRPPNI PSPPPLIHTS KPTDKPSFIQ GGSISQGTPG TYLPPQSHAV
1110 1120 1130 1140 1150
YIPEVVKTTG GSISLGLPRQ QDPAKPVSYI KQEECSPRGQ SAQAEGLLSR
1160 1170 1180 1190 1200
AQYDGVVRGG PMQIQDMRGT PGKGQEGLPF RGGSITQGTP ALTQSNVAAE
1210 1220 1230 1240 1250
LLKGTIAKLA TEDQSSPEKS RAEAHSKAHV IYEGKSGHIL SYDAIKNPRE
1260 1270 1280 1290 1300
GTRSPRMGHD LKRTYDIMEG SRGHTPRETT PYEGLICRTL RESPHESKDR
1310 1320 1330 1340 1350
PMLAGSIMQG TPRASTEVYD EASKYGKQIK RESPPIRSFE GGITKGKPYE
1360 1370 1380 1390 1400
GVNTIKEMGR SIHEIPRKET QDSRKTPVLE GSITQGIPLK YEGSAVNPSA
1410 1420 1430 1440 1450
IKHNVKSLIT SPVKISHSAI EAAERERAKY EDAKASERVR HTSVVNSTSV
1460 1470 1480 1490 1500
LRSTHAEAGK AQLSPGMYDD SNARRTPTYS STSIPRGSPL LRGQEGSITT
1510 1520 1530 1540 1550
GKPVSHERKS ALTPTQRDSV PAKSPVSGAD PLGSHSPFDP HHRPVVPGEV
1560 1570 1580 1590 1600
YRTHLPPHLD PTIAFHHRVL DPAAYMFPRQ PSPTGYPNTY QLYTMENTRQ
1610 1620 1630 1640 1650
TILNDYITSQ QMQVIPRPDL ARGLSPREQS IAIPYPPPRG IIDLAQMPPT
1660 1670 1680 1690 1700
ILLPHPGGTG SPSLDRITYI PGPQTPFPPR AFNPASISPG HPAHHSAAAA
1710 1720 1730 1740 1750
IVERETQREK ERERERERER EREQRERERA AVEYMRGGPE QPVRPGSRSF
1760 1770 1780 1790 1800
LRSTSPSVRA QEGVLQQRPS IFQGTNSKSV ITPLMPMQSQ AAAAQANSRY
1810 1820 1830 1840 1850
NNAADALAAL VDAAAAAPQM DVAKVKDGKH SNSSSRDDEV MSSRRAAQES
1860 1870 1880 1890 1900
QELERRSMQS PYGDMSLPGG KPSQSVYAEG GGAAGSKEKA PPTKSRMEEE
1910 1920 1930 1940 1950
LRTHGKTTIT AANFIDVIIT RQIAPDKDSR ERGSQSSDSS SSMSSSRYDA
1960 1970 1980 1990 2000
QGGIEVISPA NSPALREDKS EGSFPSEKSS QLPTVMSFGR YRQPGDSGPS
2010 2020 2030 2040 2050
APQPPPSSQS DSYGSVPKTH RIMTLADHIS HIITQDFAKS QDTPPSSTSL
2060 2070 2080 2090 2100
PSSSSSLSST FQSSGVGGGV GRVKALNRYS PENPTSAHHQ RPARVSPENS
2110 2120 2130 2140 2150
SDKSRARPGR SPDRGRGLES YEPISPPQGY SGMDKQEASV LQSQRREQDL
2160 2170 2180 2190 2200
PEQRTDSRSP GSGIYLPSFF TKLESTSPMV MSKKQEICRK AEVGNAQPGT
2210 2220 2230 2240 2250
EIFNLPAVTT SSSVNPRNHS FSDPASNLGL EDIIRKALMG NMEEKQEDQQ
2260 2270 2280 2290 2300
QQQQTLMSAA NSSGSMSSIS ESRQEASPSP NTAGKQKLQS KASSRKSKSP
2310 2320 2330 2340 2350
NPGQAYSAGE RPSSVSSVHS EGDYHRQAPT WAWEDRPSST GSMQFPYNPL
2360 2370 2380 2390 2400
TMRMLSSTPP SSMACPSPSM QSQQQAQGGT TGPVAPTRAW EREPPLLSEQ

YETLSDSDD
Length:2,409
Mass (Da):266,771
Last modified:November 13, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4521E7C6446EC3C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF016488 mRNA Translation: ABK76313.1

NCBI Reference Sequences

More...
RefSeqi
NP_956570.2, NM_200276.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
393246

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:393246

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF016488 mRNA Translation: ABK76313.1
RefSeqiNP_956570.2, NM_200276.2

3D structure databases

SMRiA8B6H7
ModBaseiSearch...

Proteomic databases

PRIDEiA8B6H7

Genome annotation databases

GeneIDi393246
KEGGidre:393246

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9611
ZFINiZDB-GENE-040426-993, ncor1

Phylogenomic databases

OrthoDBi12227at2759
PhylomeDBiA8B6H7

Family and domain databases

CDDicd00167, SANT, 2 hits
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR031557, N-CoR_GPS2_interact
IPR001005, SANT/Myb
IPR017884, SANT_dom
PfamiView protein in Pfam
PF15784, GPS2_interact, 1 hit
PF00249, Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717, SANT, 2 hits
SUPFAMiSSF46689, SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51293, SANT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8B6H7_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8B6H7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: December 2, 2020
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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