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Entry version 42 (08 May 2019)
Sequence version 1 (13 Nov 2007)
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Protein
Submitted name:

CXC-rich protein

Gene

GL50803_14225

Organism
Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metalloendopeptidase activity Source: InterPro
  • peptidase activity Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CXC-rich proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:GL50803_14225Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGiardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri184922 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
GiardiaDB:GL50803_14225

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1752 – 1776HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500271725519 – 1805Sequence analysisAdd BLAST1787

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8B4A2

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHICIGE

Database of Orthologous Groups

More...
OrthoDBi
53897at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR001577 Peptidase_M8

The PANTHER Classification System

More...
PANTHERi
PTHR10942 PTHR10942, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8B4A2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLILSWLLPC LLTVSVSTEM ELRKALSNGR DVTLNDDITL KLPWMPVPAY
60 70 80 90 100
GKVFDGKGHT IRNISVSSTV PASQGSGLFS ELTGGSISNL NLQFNTTIDS
110 120 130 140 150
GLILFGGVSA KASDKARVTN VNVSGTVSIK SHADGNVTVG CIFGTAGDTG
160 170 180 190 200
TREPSDAVRS DCIVTVNASN ANLRLGGFIG ILENTAVAMH YTGKPRVGCH
210 220 230 240 250
AKRCYVGGFA SMATGPIQDV HFTDSVVNAT ALRHSIVGGI VGHGNNIQLC
260 270 280 290 300
SSYNSTISVT STGRVLAGVS VGGAVGETNA ENYVINTTFV KASMIVLETR
310 320 330 340 350
SSSYLGGVLG YGKHRGGTMT NSYAVVQSLR GYNNGGHMYG GGFLGYGNAS
360 370 380 390 400
SLTLSTCYMF VPEFQFFEKP GAGGQSYYGG FFGLINGSSS DTPSVHSIQA
410 420 430 440 450
GMGKFEVRMV AQGTNAGNFG GAIEAARETL IERIVLMGAA GIWSGEAPEN
460 470 480 490 500
AAIFIGKVGP GINLKTILVN ISIGNGNNLP NTANFVNTFT GTATDIVYNS
510 520 530 540 550
GIVKTSQFMP ASGTYQNFNI RVNTTTQVSC ENYLQKHGLD SSKVNCADDL
560 570 580 590 600
YLNKTTSSAQ INTDWKFETV DNWEHDPKGW YLPKGMPVAN SAINNPALFM
610 620 630 640 650
TIYLDAKGKT GLSWQNSGWD NETIWRFGNT NEADTTKAIP PSFPALWKNP
660 670 680 690 700
ESFLACTPQS CGRESFFSPF MCNCLHGCPD LKNGQCSSYN GATCDEGWKN
710 720 730 740 750
VGTSLCSGFS CAGKDQLCGG SQVAECDAGS SLCKCKEHEK YYNISTKTCE
760 770 780 790 800
MGCQGIGHGF CTGPGVAMCD KGWKDGEAGL CTVYSCSSDD PTTACGGSSV
810 820 830 840 850
AKCITAYDVC NCTVQTSAYN PENKQCEPNK CTIASGDHIC IGENKAICMS
860 870 880 890 900
NTWPTSGTSG ETLCAHYDCM RHQQCAAGSV CDIDTFACRC ANPTHYFDTA
910 920 930 940 950
DNTCKDGCTG LNAHTGVCIG SNKALCYKGY TSPSSGGPLC SQYSCADADP
960 970 980 990 1000
TCGGHGTCNS GTCTCNEGTL KLNNTCYANI CIRGTVSNQN ACTCTSGWQD
1010 1020 1030 1040 1050
DTDLAPLKCT KPSTCPDSIN INSDADLIYL YSCGSATYNL LGNVTVSYPW
1060 1070 1080 1090 1100
LPVPSFTGVF NGNGYALKGV RLYENDTVAA LYKTIDENAN ITNLIVEFAT
1110 1120 1130 1140 1150
NISSSTIKKI AGITPDLNGK VLANVTAAGS ISVKVGAIEV DVGGLADTCM
1160 1170 1180 1190 1200
GLGNVTFSGY LAVDSHAAVR VGALCASASS PLSDLATSGS ISCTSRGRCL
1210 1220 1230 1240 1250
VGGLVSNTTH NISSSSSNIS ITVSSINGLV GGVVSNTTGN LTNLTFTGIV
1260 1270 1280 1290 1300
SSPLDSTATV GGIVGVAKPQ SSQSLTIKGC SVVSKAVSAS SAGGLVGAIE
1310 1320 1330 1340 1350
DGVIEESSVT LTALEGSICA GGLVCNATHT TIAKSNSNIN ALRFTASYTE
1360 1370 1380 1390 1400
ESAKQYCGGF VASATETTIE DSYSIVTAST VKTSSEAFVG GFAGSTDGLT
1410 1420 1430 1440 1450
VKRSYASGDS VNLAPDNILH FGGFVGSCIC NIDSSFSKIT LMALNKRKIN
1460 1470 1480 1490 1500
NAHFGGFVGI IKRNSASDGR TASASPQISN SWVSSSMSVL LSSPEASRVF
1510 1520 1530 1540 1550
YGGFSGEADA STITDSYTRS NLSVNNDINL YHTGFGAFNG RFNELETNIT
1560 1570 1580 1590 1600
RCYADVGIDG ATDLNFEGNS AYGKKCAKCT KVLINSDQPG ISDENACGRT
1610 1620 1630 1640 1650
AAELQKSETI MKEFGSTDAF AFESGRMPMI VTTPNLDSVT HTYVYPSCNP
1660 1670 1680 1690 1700
STQGNCWDYK NTWIVSPDGI GSVATAPDCK VSSCTYCDAR DSGICRICAS
1710 1720 1730 1740 1750
RTFLDSRKTC SACSSSCAEC ATKESFCTAC KRSGAMPNVD GVCIMPRLSS
1760 1770 1780 1790 1800
AAIAGISIVV ILVISGVVGF LCWWFICRSK SRPTENPVHT LEPSVSTVSI

NESIL
Length:1,805
Mass (Da):188,755
Last modified:November 13, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FD5067F5B05FA52
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AACB02000002 Genomic DNA Translation: EDO81859.1

NCBI Reference Sequences

More...
RefSeqi
XP_001709533.1, XM_001709481.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EDO81859; EDO81859; GL50803_14225

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5702457

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gla:GL50803_14225

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACB02000002 Genomic DNA Translation: EDO81859.1
RefSeqiXP_001709533.1, XM_001709481.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEDO81859; EDO81859; GL50803_14225
GeneIDi5702457
KEGGigla:GL50803_14225

Organism-specific databases

EuPathDBiGiardiaDB:GL50803_14225

Phylogenomic databases

InParanoidiA8B4A2
OMAiDHICIGE
OrthoDBi53897at2759

Family and domain databases

InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR001577 Peptidase_M8
PANTHERiPTHR10942 PTHR10942, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8B4A2_GIAIC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8B4A2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 8, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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