UniProtKB - A8B338 (A8B338_GIAIC)
Protein
Submitted name:
Peroxiredoxin 1
Gene
GL50803_0014521
Organism
Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia)
Status
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.UniRule annotation
Caution
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 50 | Cysteine sulfenic acid (-SOH) intermediateUniRule annotation | 1 |
GO - Molecular functioni
- thioredoxin peroxidase activity Source: GO_Central
GO - Biological processi
- cell redox homeostasis Source: GO_Central
- response to oxidative stress Source: GO_Central
Keywordsi
Molecular function | AntioxidantUniRule annotation, Oxidoreductase, PeroxidaseUniRule annotationImported |
Protein family/group databases
PeroxiBasei | 5983, Gint2CysPrx01_50803 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:GL50803_0014521Imported, GL50803_14521Imported |
Organismi | Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia)Imported |
Taxonomic identifieri | 184922 [NCBI] |
Taxonomic lineagei | Eukaryota › Metamonada › Diplomonadida › Hexamitidae › Giardiinae › Giardia › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | GiardiaDB:GL50803_14521 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 164 | ThioredoxinInterPro annotationAdd BLAST | 161 |
Sequence similaritiesi
Belongs to the peroxiredoxin family.UniRule annotation
Keywords - Domaini
Redox-active centerUniRule annotationPhylogenomic databases
HOGENOMi | CLU_042529_21_1_1 |
InParanoidi | A8B338 |
OrthoDBi | 1326484at2759 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A8B338-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVPIPGTPC PDFEVDVVTP ELKFAKRKLS DYKGKYLIVF FYPLDFTFVC
60 70 80 90 100
PSEIIHFSNL AEQLKKKCNA EIIIGSTDSV YSHYAWCLQG QNEGGIGTCK
110 120 130 140 150
CDLFADTNHK MARDFGVLVE DAGIALRGMF IVSDKGVVRH VTINDLPVGR
160 170 180 190 200
SVEEAMRLVQ AFQYADKTGG VIPCGWTPEK NDTIIPDPEK KKEYFSKTFK
K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACB02000001 Genomic DNA Translation: EDO82442.1 AACB03000003 Genomic DNA Translation: KAE8303094.1 |
RefSeqi | XP_001710116.1, XM_001710064.1 |
Genome annotation databases
EnsemblProtistsi | EDO82442; EDO82442; GL50803_14521 |
GeneIDi | 5703042 |
KEGGi | gla:GL50803_14521 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACB02000001 Genomic DNA Translation: EDO82442.1 AACB03000003 Genomic DNA Translation: KAE8303094.1 |
RefSeqi | XP_001710116.1, XM_001710064.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
PeroxiBasei | 5983, Gint2CysPrx01_50803 |
Genome annotation databases
EnsemblProtistsi | EDO82442; EDO82442; GL50803_14521 |
GeneIDi | 5703042 |
KEGGi | gla:GL50803_14521 |
Organism-specific databases
VEuPathDBi | GiardiaDB:GL50803_14521 |
Phylogenomic databases
HOGENOMi | CLU_042529_21_1_1 |
InParanoidi | A8B338 |
OrthoDBi | 1326484at2759 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8B338_GIAIC | |
Accessioni | A8B338Primary (citable) accession number: A8B338 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 13, 2007 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 10, 2021 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |