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Entry version 81 (02 Jun 2021)
Sequence version 1 (23 Oct 2007)
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Protein

Streptococcal surface protein A

Gene

sspA

Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adhesin that mediates binding of bacteria to a variety of host cells. Plays a role in the bacterial invasion of dentinal tubules (PubMed:9393810).

A host immunostimulatory component, it modulates the innate immunity response. Plays a protective role against some antibiotics and cationic antimicrobial peptides (histatin-5, HTN3, but not beta-defensin 4A, DEFB4A). Purified soluble protein stimulates human epithelial cells to produce IL-6 and monocyte chemotactic protein (MCP-1, CCL2) probably via interaction with integrin beta-1 (ITGB1) (PubMed:22609749).

2 Publications

Miscellaneous

S.gordonii, a commensal oral cavity bacteria, is among the bacteria most frequently identified as being the primary etiological agents of subacute infective endocarditis (found in 13% of cases).1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processVirulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SGOR467705:G1G95-209-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Streptococcal surface protein A
Alternative name(s):
Adhesin SspS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sspA1 Publication
Ordered Locus Names:SGO_0210
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri467705 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001131 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell wall, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Single sspA deletion, bacteria invade human dental roots less well, adhere less well to collagen, decreased accumulation of mature SspB; double sspA-sspB deletion, no invasion of dental roots, collagen adherence is further reduced, as is chaining on soluble collagen (PubMed:9393810). Triple sspA-sspB-hsa deletion no longer causes human platelet aggregation; double sspA-sspB deletion still causes platelet aggregation (PubMed:19884334). Double sspA-sspB adheres better to human epithelial cells and is internalized better than wild-type cells, but induces less host cytokine production (IL-6, IL-8, monocyte chemotactic protein). Stimulates less cytokine production in mouse bone marrow-derived dendritic cells (IL-6, IL-10, IL-12, tumor necrosis factor). Increased sensitivity to antibiotics polymyxin B and nisin, and human histatin-5 (His3-(20-43)-peptide, HTN3). In intranasal mouse infection, the double mutant is cleared less quickly from lungs, neutrophil, hemokine and cytokine production are delayed or reduced (PubMed:22609749).3 Publications

Keywords - Diseasei

Dental caries

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 38Sequence analysisAdd BLAST38
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500271765239 – 1575Streptococcal surface protein ASequence analysisAdd BLAST1537
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_50183508621543 – 1575Removed by sortasePROSITE-ProRule annotationAdd BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1542Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by growth in the presence of collagen (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to human integrin beta-1 (ITGB1).

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
467705.SGO_0210

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati146 – 220Ag I/II A 1PROSITE-ProRule annotationAdd BLAST75
Repeati221 – 302Ag I/II A 2PROSITE-ProRule annotationAdd BLAST82
Repeati303 – 384Ag I/II A 3PROSITE-ProRule annotationAdd BLAST82
Repeati385 – 466Ag I/II A 4PROSITE-ProRule annotationAdd BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1539 – 1543LPXTG sorting signalPROSITE-ProRule annotation5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the antigen I/II family.1 Publication

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3064, Bacteria
COG3087, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_257994_0_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSWYGAG

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.530.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026345, Adh_isopep-form_adh_dom
IPR041324, AgI/II_N
IPR032300, Antigen_C
IPR021197, Cross-wall-target_lipo_motif
IPR013574, Glucan-bd_C/Surface_Ag-I/II_V
IPR019948, Gram-positive_anchor
IPR019931, LPXTG_anchor
IPR036234, SA_I/II_PAC_V_sf
IPR009578, Surface_Ag_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18652, Adhesin_P1_N, 1 hit
PF17998, AgI_II_C2, 1 hit
PF16364, Antigen_C, 1 hit
PF08363, GbpC, 1 hit
PF00746, Gram_pos_anchor, 1 hit
PF06696, Strep_SA_rep, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74914, SSF74914, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04228, isopep_sspB_C2, 1 hit
TIGR03726, strep_RK_lipo, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51965, AG_I_II_AR, 4 hits
PS50847, GRAM_POS_ANCHORING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A8AUS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKRKEVFGF RKSKVAKTLC GAVLGAALIA IADQQVLADE VTETNSTANV
60 70 80 90 100
AVTTTGNPAT NLPEAQGEAT EAASQSQAQA GSKEGALPVE VSADDLNQAV
110 120 130 140 150
TDAKAAGVNV VQDQTSDKGT ATTAAENAQK QAEIKSDYAK QAEEIKKTTE
160 170 180 190 200
AYKKEVEAHQ AETDKINAEN KAAEDKYQED LKAHQAEVEK INTANATAKA
210 220 230 240 250
EYEAKLAQYQ KDLAAVQKAN EDSQLDYQNK LSAYQAELAR VQKANAEAKE
260 270 280 290 300
AYEKAVKENT AKNAALQAEN EAIKQRNETA KANYDAAMKQ YEADLAAIKK
310 320 330 340 350
AKEDNDADYQ AKLAAYQAEL ARVQKANADA KAAYEKAVEE NTAKNTAIQA
360 370 380 390 400
ENEAIKQRNA AAKATYEAAL KQYEADLAAA KKANEDSDAD YQAKLAAYQT
410 420 430 440 450
ELARVQKANA DAKAAYEKAV EDNKAKNAAL QAENEEIKQR NAAAKTDYEA
460 470 480 490 500
KLAKYEADLA KYKKELAEYP AKLKAYEDEQ AQIKAALVEL EKNKNQDGYL
510 520 530 540 550
SKPSAQSLVY DSEPNAQLSL TTNGKMLKAS AVDEAFSHDT AQYSKKILQP
560 570 580 590 600
DNLNVSYLQQ ADDVTSSMEL YGNFGDKAGW TTTVGNNTEV KFASVLLERG
610 620 630 640 650
QSVTATYTNL EKSYYNGKKI SKVVFKYTLD SDSKFKNVDK AWLGVFTDPT
660 670 680 690 700
LGVFASAYTG QEEKDTSIFI KNEFTFYDEN DQPINFDNAL LSVASLNREN
710 720 730 740 750
NSIEMAKDYS GTFVKISGSS VGEKDGKIYA TETLNFKQGQ GGSRWTMYKN
760 770 780 790 800
SQPGSGWDSS DAPNSWYGAG AISMSGPTNH VTVGAISATQ VVPSDPVMAV
810 820 830 840 850
ATGKRPNIWY SLNGKIRAVN VPKITKEKPT PPVAPTEPQA PTYEVEKPLE
860 870 880 890 900
PAPVAPTYEN EPTPPVKTPD QPEPSKPEEP TYETEKPLEP APVVPTYENE
910 920 930 940 950
PTPPVKTPDQ PEPSKPEEPT YETEKPLEPA PVAPTYENEP TPPVKTPDQP
960 970 980 990 1000
EPSKPEEPTY DPLPTPPVAP TPKQLPTPPV VPTVHFHYSS LLAQPQINKE
1010 1020 1030 1040 1050
IKNEDGVDID RTLVAKQSIV KFELKTEALT AGRPKTTSFV LVDPLPTGYK
1060 1070 1080 1090 1100
FDLDATKAAS TGFDTTYDEA SHTVTFKATD ETLATYNADL TKPVETLHPT
1110 1120 1130 1140 1150
VVGRVLNDGA TYTNNFTLTV NDAYGIKSNV VRVTTPGKPN DPDNPNNNYI
1160 1170 1180 1190 1200
KPTKVNKNKE GLNIDGKEVL AGSTNYYELT WDLDQYKGDK SSKEAIQNGF
1210 1220 1230 1240 1250
YYVDDYPEEA LDVRPDLVKV ADEKGNQVSG VSVQQYDSLE AAPKKVQDLL
1260 1270 1280 1290 1300
KKANITVKGA FQLFSADNPE EFYKQYVSTG TSLVITDPMT VKSEFGKTGG
1310 1320 1330 1340 1350
KYENKAYQID FGNGYATEVV VNNVPKITPK KDVTVSLDPT SENLDGQTVQ
1360 1370 1380 1390 1400
LYQTFNYRLI GGLIPQNHSE ELEDYSFVDD YDQAGDQYTG NYKTFSSLNL
1410 1420 1430 1440 1450
TMKDGSVIKA GTDLTSQTTA ETDAANGIVT VRFKEDFLQK ISLDSPFQAE
1460 1470 1480 1490 1500
TYLQMRRIAI GTFENTYVNT VNKVAYASNT VRTTTPIPRT PDKPTPIPTP
1510 1520 1530 1540 1550
KPKDPDKPET PKEPKVPSPK VEDPSAPIPV SVGKELTTLP KTGTNDSSYM
1560 1570
PYLGLAALVG VLGLGQLKRK EDESN
Length:1,575
Mass (Da):171,926
Last modified:October 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F9EA5F22CC2278D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000725 Genomic DNA Translation: ABV10916.1

NCBI Reference Sequences

More...
RefSeqi
WP_011999747.1, NC_009785.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABV10916; ABV10916; SGO_0210

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sgo:SGO_0210

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA Translation: ABV10916.1
RefSeqiWP_011999747.1, NC_009785.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi467705.SGO_0210

Genome annotation databases

EnsemblBacteriaiABV10916; ABV10916; SGO_0210
KEGGisgo:SGO_0210

Phylogenomic databases

eggNOGiCOG3064, Bacteria
COG3087, Bacteria
HOGENOMiCLU_257994_0_0_9
OMAiNSWYGAG

Enzyme and pathway databases

BioCyciSGOR467705:G1G95-209-MONOMER

Family and domain databases

Gene3Di2.60.530.10, 1 hit
InterProiView protein in InterPro
IPR026345, Adh_isopep-form_adh_dom
IPR041324, AgI/II_N
IPR032300, Antigen_C
IPR021197, Cross-wall-target_lipo_motif
IPR013574, Glucan-bd_C/Surface_Ag-I/II_V
IPR019948, Gram-positive_anchor
IPR019931, LPXTG_anchor
IPR036234, SA_I/II_PAC_V_sf
IPR009578, Surface_Ag_rpt
PfamiView protein in Pfam
PF18652, Adhesin_P1_N, 1 hit
PF17998, AgI_II_C2, 1 hit
PF16364, Antigen_C, 1 hit
PF08363, GbpC, 1 hit
PF00746, Gram_pos_anchor, 1 hit
PF06696, Strep_SA_rep, 5 hits
SUPFAMiSSF74914, SSF74914, 1 hit
TIGRFAMsiTIGR04228, isopep_sspB_C2, 1 hit
TIGR03726, strep_RK_lipo, 1 hit
PROSITEiView protein in PROSITE
PS51965, AG_I_II_AR, 4 hits
PS50847, GRAM_POS_ANCHORING, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSPA_STRGC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8AUS0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 2, 2021
Last sequence update: October 23, 2007
Last modified: June 2, 2021
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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