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Protein

tRNA pseudouridine synthase D

Gene

truD

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei27SubstrateUniRule annotation1
Active sitei80NucleophileUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei329SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciCKOS290338:G1G9Z-3609-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:CKO_04106
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCitrobacter
Proteomesi
  • UP000008148 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000847331 – 349tRNA pseudouridine synthase DAdd BLAST349

Proteomic databases

PRIDEiA8ANV9

Interactioni

Protein-protein interaction databases

STRINGi290338.CKO_04106

Structurei

3D structure databases

ProteinModelPortaliA8ANV9
SMRiA8ANV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 303TRUDUniRule annotationAdd BLAST149

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106NZV Bacteria
COG0585 LUCA
HOGENOMiHOG000224848
KOiK06176
OMAiLWLWVEK
OrthoDBiPOG091H03KK

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 2 hits
PfamiView protein in Pfam
PF01142 TruD, 2 hits
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

A8ANV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEFENLTYL HGKPQGAGLL KANPEDFVVV EDLGFEPDGE GEHILVRILK
60 70 80 90 100
NGCNTRFVAD ALAKFLKIHA REVSFAGQKD KHAVTEQWLC ARVPGKEMPD
110 120 130 140 150
LSAFQIEGCK VLEYARHKRK LRLGALKGNA FTLVLREVSH RDDVEARLQA
160 170 180 190 200
INTRGVPNYF GAQRFGIGGS NLQGALRWAQ SNAPVRDRNK RSFWLSAARS
210 220 230 240 250
ALFNQIVNER VKKPDFNQVV DGDALQLAGR GSWFVATQEE QAELQRRVDE
260 270 280 290 300
KELMITAALP GSGEWGTLRD ALAFEEAAIA DEGELQSLLL REKVEAARRA
310 320 330 340
MLLYPQQLRW NWWDDVTVEL RFWLPAGSFA TSVVRELINT MGDYAHIAE
Length:349
Mass (Da):39,258
Last modified:October 23, 2007 - v1
Checksum:i0096EA9A3DB23F1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA Translation: ABV15172.1
RefSeqiWP_012134861.1, NC_009792.1

Genome annotation databases

EnsemblBacteriaiABV15172; ABV15172; CKO_04106
KEGGicko:CKO_04106

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA Translation: ABV15172.1
RefSeqiWP_012134861.1, NC_009792.1

3D structure databases

ProteinModelPortaliA8ANV9
SMRiA8ANV9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290338.CKO_04106

Proteomic databases

PRIDEiA8ANV9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV15172; ABV15172; CKO_04106
KEGGicko:CKO_04106

Phylogenomic databases

eggNOGiENOG4106NZV Bacteria
COG0585 LUCA
HOGENOMiHOG000224848
KOiK06176
OMAiLWLWVEK
OrthoDBiPOG091H03KK

Enzyme and pathway databases

BioCyciCKOS290338:G1G9Z-3609-MONOMER

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 2 hits
PfamiView protein in Pfam
PF01142 TruD, 2 hits
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRUD_CITK8
AccessioniPrimary (citable) accession number: A8ANV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: November 7, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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