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Protein

5'-deoxynucleotidase CKO_00504

Gene

CKO_00504

Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.UniRule annotation

Catalytic activityi

A 2'-deoxyribonucleoside 5'-monophosphate + H2O = a 2'-deoxyribonucleoside + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei18Appears to be important in orienting the phosphate for catalysisUniRule annotation1
Metal bindingi33Divalent metal cation; via tele nitrogenUniRule annotation1
Binding sitei33SubstrateUniRule annotation1
Metal bindingi68Divalent metal cation; via tele nitrogenUniRule annotation1
Metal bindingi69Divalent metal cationUniRule annotation1
Binding sitei69SubstrateUniRule annotation1
Metal bindingi137Divalent metal cationUniRule annotation1
Binding sitei137SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'-deoxynucleotidase CKO_00504UniRule annotation (EC:3.1.3.89UniRule annotation)
Alternative name(s):
5'-deoxyribonucleotidaseUniRule annotation
Nucleoside 5'-monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Ordered Locus Names:CKO_00504
OrganismiCitrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Taxonomic identifieri290338 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCitrobacter
Proteomesi
  • UP000008148 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000649471 – 1995'-deoxynucleotidase CKO_00504Add BLAST199

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290338.CKO_00504

Structurei

3D structure databases

ProteinModelPortaliA8ADU7
SMRiA8ADU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 142HDPROSITE-ProRule annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 19Substrate bindingUniRule annotation2
Regioni77 – 80Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the 5DNU family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DK2 Bacteria
COG1896 LUCA
HOGENOMiHOG000276964
KOiK08722
OMAiNQSHFFA
OrthoDBiPOG091H00DC

Family and domain databases

CDDicd00077 HDc, 1 hit
HAMAPiMF_01100 5DNU, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR006674 HD_domain
IPR039356 Nucleoside_monoPase
IPR022971 YfbR
PANTHERiPTHR11845 PTHR11845, 1 hit
PfamiView protein in Pfam
PF13023 HD_3, 1 hit
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS51831 HD, 1 hit

Sequencei

Sequence statusi: Complete.

A8ADU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQSHFFAHL SRLKLINRWP LMRNVRTENV SEHSLQVAMV AHALAAIKNR
60 70 80 90 100
KFGGQVNAER IALLAMYHDA SEVLTGDLPT PVKYFNSQIA QEYKAIEKIA
110 120 130 140 150
QQKLVDMVPD ELRDIFAPLI DEHAYSEEEK SVVKQADALC AYLKCLEELS
160 170 180 190
AGNNEFLLAK TRLEKTLASR RSEEMDYFMA VFVPSFHLSL DEISQDSPL
Length:199
Mass (Da):22,668
Last modified:October 23, 2007 - v1
Checksum:iEF93CA5B7479B1FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA Translation: ABV11660.1
RefSeqiWP_012131486.1, NC_009792.1

Genome annotation databases

EnsemblBacteriaiABV11660; ABV11660; CKO_00504
KEGGicko:CKO_00504

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000822 Genomic DNA Translation: ABV11660.1
RefSeqiWP_012131486.1, NC_009792.1

3D structure databases

ProteinModelPortaliA8ADU7
SMRiA8ADU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290338.CKO_00504

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV11660; ABV11660; CKO_00504
KEGGicko:CKO_00504

Phylogenomic databases

eggNOGiENOG4105DK2 Bacteria
COG1896 LUCA
HOGENOMiHOG000276964
KOiK08722
OMAiNQSHFFA
OrthoDBiPOG091H00DC

Family and domain databases

CDDicd00077 HDc, 1 hit
HAMAPiMF_01100 5DNU, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR006674 HD_domain
IPR039356 Nucleoside_monoPase
IPR022971 YfbR
PANTHERiPTHR11845 PTHR11845, 1 hit
PfamiView protein in Pfam
PF13023 HD_3, 1 hit
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS51831 HD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei5DNU_CITK8
AccessioniPrimary (citable) accession number: A8ADU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: September 12, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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