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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciIHOS453591:G1G9W-711-MONOMER
UniPathwayi
UPA00251;UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Igni_0683
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
Proteomesi
  • UP000000262 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003823951 – 423Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi453591.Igni_0683

Structurei

3D structure databases

ProteinModelPortaliA8AAB3
SMRiA8AAB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00918 Archaea
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG093Z024H

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

A8AAB3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRSLELFQI AKNLFPGGVN SPIRAAVKPY PFYVKKASGA TLVTVDGVEL
60 70 80 90 100
IDYVLGYGPL ILGHMHPKVL EAVEEQLNRG WLYGTPHELE IELAKKIVSH
110 120 130 140 150
YPSIDMVRFV NSGTEATMTA IRLARGFTKK NKIIKFDGCY HGAHDSVLVK
160 170 180 190 200
AGSAVSHFGV PGSAGVPEEV SKLTLVVPFN DVEAVEKVAK ENQDDLAAII
210 220 230 240 250
VEPVMGNAGV IPPKEGFLKE LRRIADETGA LLIFDEVITG YRLGLGGAQA
260 270 280 290 300
KFGVVPDLTT LGKIVGGGFP VGVVGGKREI MEYLTPSGPV FNAGTFNAHP
310 320 330 340 350
VTMAAGLATI NELERGYVYE VANSAAEKVA KALEQEAVAK FGGVVHRVAS
360 370 380 390 400
MFQWFPGVEE VNNYADALKA NKEISLRLHE ELLKRGVFIA PSLFEAWFTS
410 420
AAHGEDVVNK TLEALSEALK VIS
Length:423
Mass (Da):45,539
Last modified:October 23, 2007 - v1
Checksum:i0F6FFB0AB5C2E704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA Translation: ABU81865.1
RefSeqiWP_011998717.1, NC_009776.1

Genome annotation databases

EnsemblBacteriaiABU81865; ABU81865; Igni_0683
GeneIDi5561840
KEGGiiho:Igni_0683

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA Translation: ABU81865.1
RefSeqiWP_011998717.1, NC_009776.1

3D structure databases

ProteinModelPortaliA8AAB3
SMRiA8AAB3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi453591.Igni_0683

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU81865; ABU81865; Igni_0683
GeneIDi5561840
KEGGiiho:Igni_0683

Phylogenomic databases

eggNOGiarCOG00918 Archaea
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG093Z024H

Enzyme and pathway databases

UniPathwayi
UPA00251;UER00317

BioCyciIHOS453591:G1G9W-711-MONOMER

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSA_IGNH4
AccessioniPrimary (citable) accession number: A8AAB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: October 23, 2007
Last modified: October 10, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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