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Protein

Thiamine thiazole synthase

Gene

thi4

Organism
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NAD; via amide nitrogenUniRule annotation1
Binding sitei63NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei134NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi166Iron; shared with adjacent protomerUniRule annotation1
Metal bindingi181IronUniRule annotation1
Binding sitei230NAD; via amide nitrogenUniRule annotation1
Binding sitei240GlycineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi55 – 56NADUniRule annotation2
Nucleotide bindingi164 – 166NAD; shared with adjacent protomerUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processThiamine biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation, NADUniRule annotation

Enzyme and pathway databases

BioCyciIHOS453591:G1G9W-585-MONOMER
UniPathwayiUPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine thiazole synthaseUniRule annotation (EC:4.-.-.-UniRule annotation)
Gene namesi
Name:thi4UniRule annotation
Ordered Locus Names:Igni_0560Imported
OrganismiIgnicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)Imported
Taxonomic identifieri453591 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeIgnicoccus
Proteomesi
  • UP000000262 Componenti: Chromosome

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi453591.Igni_0560

Structurei

3D structure databases

ProteinModelPortaliA8A9Z0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the THI4 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00574 Archaea
COG1635 LUCA
HOGENOMiHOG000106048
KOiK03146
OMAiMWGGGMM
OrthoDBiPOG093Z09PU

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR000103 Pyridine_nuc-diS_OxRdtase_2
IPR002922 Thi4_fam
IPR022828 Thi4_prok
PRINTSiPR00469 PNDRDTASEII
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit

Sequencei

Sequence statusi: Complete.

A8A9Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDEGIITTT ILKKSTEELM SYAQSSDVIV VGAGPAGLTA AYYLAKEGFK
60 70 80 90 100
TLVLERRISY GGGINGGGTL FHKVVVEDLE VDGYSTSDVV RELGLTLEET
110 120 130 140 150
EYDGVKLVDA VALTATLAFK AVEAGAKVLL GWHVEDLIYR EVDGKVKVTG
160 170 180 190 200
VVALWSPIEI AGLHVDPIFF KSKAVVDATG HGAEVLKVAE RKLNLPLGVA
210 220 230 240 250
TEKGAWAERA EELVVKETGK VVDGLYAAGM SVASWKRLPR MGPAISGMLL
260
SGKKVADQIK GDLRS
Length:265
Mass (Da):28,188
Last modified:October 23, 2007 - v1
Checksum:i1CC9226A3D3BEF81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000816 Genomic DNA Translation: ABU81742.1
RefSeqiWP_011998594.1, NC_009776.1

Genome annotation databases

EnsemblBacteriaiABU81742; ABU81742; Igni_0560
GeneIDi5562773
KEGGiiho:Igni_0560

Similar proteinsi

Entry informationi

Entry nameiA8A9Z0_IGNH4
AccessioniPrimary (citable) accession number: A8A9Z0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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