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Entry version 90 (02 Jun 2021)
Sequence version 1 (23 Oct 2007)
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Protein

Bifunctional protein PutA

Gene

putA

Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Oxidizes proline to glutamate for use as a carbon and nitrogen source.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADUniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 1 and 2 of the subpathway that synthesizes L-glutamate from L-proline.UniRule annotation This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei883UniRule annotation1
Active sitei917UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation, OxidoreductaseUniRule annotationARBA annotation, RepressorUniRule annotation
Biological processProline metabolismUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00261;UER00373
UPA00261;UER00374

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bifunctional protein PutAUniRule annotation
Including the following 2 domains:
Proline dehydrogenaseUniRule annotation (EC:1.5.5.2UniRule annotation)
Alternative name(s):
Proline oxidaseUniRule annotation
Delta-1-pyrroline-5-carboxylate dehydrogenaseUniRule annotation (EC:1.2.1.88UniRule annotation)
Short name:
P5C dehydrogenaseUniRule annotation
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:putAImported
Ordered Locus Names:EcE24377A_1132Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli O139:H28 (strain E24377A / ETEC)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri331111 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001122 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini89 – 136PRODHInterPro annotationAdd BLAST48
Domaini148 – 259Pro_dh-DNA_bdgInterPro annotationAdd BLAST112
Domaini269 – 569Pro_dhInterPro annotationAdd BLAST301
Domaini659 – 1105AldedhInterPro annotationAdd BLAST447

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation
In the C-terminal section; belongs to the aldehyde dehydrogenase family.UniRule annotation
In the N-terminal section; belongs to the proline dehydrogenase family.UniRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005682_1_1_6

Identification of Orthologs from Complete Genome Data

More...
OMAi
VRIYAPV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1220.10, 1 hit
1.20.5.550, 1 hit
3.40.309.10, 1 hit
3.40.605.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016160, Ald_DH_CS_CYS
IPR029510, Ald_DH_CS_GLU
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR013321, Arc_rbn_hlx_hlx
IPR025703, Bifunct_PutA
IPR005933, Delta1-pyrroline-5-COlate_DH-3
IPR029041, FAD-linked_oxidoreductase-like
IPR041349, PRODH
IPR024090, PRODH_PutA_dom_I
IPR024089, PRODH_PutA_dom_I/II
IPR024082, PRODH_PutA_dom_II
IPR002872, Proline_DH_dom
IPR010985, Ribbon_hlx_hlx

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00171, Aldedh, 1 hit
PF01619, Pro_dh, 1 hit
PF14850, Pro_dh-DNA_bdg, 1 hit
PF18327, PRODH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000197, Bifunct_PutA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47598, SSF47598, 1 hit
SSF51730, SSF51730, 1 hit
SSF53720, SSF53720, 1 hit
SSF81935, SSF81935, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01238, D1pyr5carbox3, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A7ZKB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTTTMGVKL DDATRERIKS AATRIDRTPH WLIKQAIFSY LEQLENSDTL
60 70 80 90 100
PELPALLSGA ANESDEAPTP AEEPHQPFLD FAEQILPQSV SRAAITAAYR
110 120 130 140 150
RPETEAVSML LEQARLPQPV AEQAHKLAYQ LADKLRNQKN ASGRAGMVQG
160 170 180 190 200
LLQEFSLSSQ EGVALMCLAE ALLRIPDKAT RDALIRDKIS NGNWQSHIGR
210 220 230 240 250
SPSLFVNAAT WGLLFTGKLV STHNEAILSR SLNRIIGKSG EPLIRKGVDM
260 270 280 290 300
AMRLMGEQFV TGETIAEALA NARKLEEKGF RYSYDMLGEA ALTAADAQAY
310 320 330 340 350
MVSYQQAIHA IGKASNGRGI YEGPGISIKL SALHPRYSRA QYDRVMEELY
360 370 380 390 400
PRLKSLTLLA RQYDIGINID AEEADRLEIS LDLLEKLCFE PELAGWNGIG
410 420 430 440 450
FVIQAYQKRC PLVIDYLIDL ATRSRRRLMI RLVKGAYWDS EIKRAQMDGL
460 470 480 490 500
EGYPVYTRKV YTDVSYLACA KKLLAVPNLI YPQFATHNAH TLAAIYQLAG
510 520 530 540 550
QNYYPGQYEF QCLHGMGEPL YEQVTGKVAD GKLNRPCRIY APVGTHETLL
560 570 580 590 600
AYLVRRLLEN GANTSFVNRI ADTSLPLDEL VADPVTAVEK LAQQEGQTGL
610 620 630 640 650
PHPKIPLPRD LYGHGRDNSA GLDLANEHRL ASLSSALLNS ALQKWQALPM
660 670 680 690 700
LEQPVAAGEM SPVINPAEPK DIVGYVREAT PREVEQALES AVNNAPIWFA
710 720 730 740 750
TPPAERAAIL HRAAVLMESQ MQQLIGILVR EAGKTFSNAI AEVREAVDFL
760 770 780 790 800
HYYAGQVRDD FANETHRPLG PVVCISPWNF PLAIFTGQIA AALAAGNSVL
810 820 830 840 850
AKPAEQTPLI AAQGIAILLE AGVPPGVVQL LPGRGETVGA QLTGDDRVRG
860 870 880 890 900
VMFTGSTEVA TLLQRNIASR LDAQGRPIPL IAETGGMNAM IVDSSALTEQ
910 920 930 940 950
VVVDVLASAF DSAGQRCSAL RVLCLQDEIA DHTLKMLRGA MAECRMGNPG
960 970 980 990 1000
RLTTDIGPVI DSEAKANIER HIQTMRSKGR PVFQAVRENS EDAREWQSGT
1010 1020 1030 1040 1050
FVAPTLIELD DFAELQKEVF GPVLHVVRYN RNQLPELIEQ INASGYGLTL
1060 1070 1080 1090 1100
GVHTRIDETI AQVTGSAHVG NLYVNRNMVG AVVGVQPFGG EGLSGTGPKA
1110 1120 1130 1140 1150
GGPLYLYRLL ANRPESALAV TLARQDAEYP VDAQLKAALT QPLNALREWA
1160 1170 1180 1190 1200
ANRPELQALC TQYGELAQAG TQRLLPGPTG ERNTWTLLPR ERVLCIADDE
1210 1220 1230 1240 1250
QDALTQLAAV LAVGSQVLWP DDALHRQLVK ALPSAVSERI QLAKAENITA
1260 1270 1280 1290 1300
QPFDAVIFHG DSDQLRALCE AVAARDGAIV SVQGFARGES NILLERLYIE
1310 1320
RSLSVNTAAA GGNASLMTIG
Length:1,320
Mass (Da):143,796
Last modified:October 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i457D0C5A237C0EF6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000800 Genomic DNA Translation: ABV20412.1

NCBI Reference Sequences

More...
RefSeqi
WP_001326117.1, NC_009801.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABV20412; ABV20412; EcE24377A_1132

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecw:EcE24377A_1132

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000800 Genomic DNA Translation: ABV20412.1
RefSeqiWP_001326117.1, NC_009801.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiABV20412; ABV20412; EcE24377A_1132
KEGGiecw:EcE24377A_1132

Phylogenomic databases

HOGENOMiCLU_005682_1_1_6
OMAiVRIYAPV

Enzyme and pathway databases

UniPathwayiUPA00261;UER00373
UPA00261;UER00374

Family and domain databases

Gene3Di1.10.1220.10, 1 hit
1.20.5.550, 1 hit
3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016160, Ald_DH_CS_CYS
IPR029510, Ald_DH_CS_GLU
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR013321, Arc_rbn_hlx_hlx
IPR025703, Bifunct_PutA
IPR005933, Delta1-pyrroline-5-COlate_DH-3
IPR029041, FAD-linked_oxidoreductase-like
IPR041349, PRODH
IPR024090, PRODH_PutA_dom_I
IPR024089, PRODH_PutA_dom_I/II
IPR024082, PRODH_PutA_dom_II
IPR002872, Proline_DH_dom
IPR010985, Ribbon_hlx_hlx
PfamiView protein in Pfam
PF00171, Aldedh, 1 hit
PF01619, Pro_dh, 1 hit
PF14850, Pro_dh-DNA_bdg, 1 hit
PF18327, PRODH, 1 hit
PIRSFiPIRSF000197, Bifunct_PutA, 1 hit
SUPFAMiSSF47598, SSF47598, 1 hit
SSF51730, SSF51730, 1 hit
SSF53720, SSF53720, 1 hit
SSF81935, SSF81935, 1 hit
TIGRFAMsiTIGR01238, D1pyr5carbox3, 1 hit
PROSITEiView protein in PROSITE
PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA7ZKB9_ECO24
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7ZKB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 2, 2021
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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