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Protein

Imidazole glycerol phosphate synthase subunit HisF

Gene

hisF

Organism
Campylobacter concisus (strain 13826)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.UniRule annotation

Catalytic activityi

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13UniRule annotation1
Active sitei132UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00010

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazole glycerol phosphate synthase subunit HisFUniRule annotation (EC:4.1.3.-UniRule annotation)
Alternative name(s):
IGP synthase cyclase subunitUniRule annotation
IGP synthase subunit HisFUniRule annotation
ImGP synthase subunit HisFUniRule annotation
Short name:
IGPS subunit HisFUniRule annotation
Gene namesi
Name:hisFUniRule annotation
Ordered Locus Names:Ccon26_19890
ORF Names:CCC13826_1890
OrganismiCampylobacter concisus (strain 13826)
Taxonomic identifieri360104 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000001121 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000729221 – 251Imidazole glycerol phosphate synthase subunit HisFAdd BLAST251

Interactioni

Subunit structurei

Heterodimer of HisH and HisF.UniRule annotation

Protein-protein interaction databases

STRINGi360104.CCC13826_1890

Structurei

3D structure databases

ProteinModelPortaliA7ZGB2
SMRiA7ZGB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0S Bacteria
COG0107 LUCA
HOGENOMiHOG000224612
KOiK02500
OMAiKRIVPCL
OrthoDBiPOG091H06EY

Family and domain databases

CDDicd04731 HisF, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01013 HisF, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR006062 His_biosynth
IPR004651 HisF
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00977 His_biosynth, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR00735 hisF, 1 hit

Sequencei

Sequence statusi: Complete.

A7ZGB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHFAKRIIP CLDVKDGRVV KGVNFVGLVD AGDPVEIAKR YNDEGADELC
60 70 80 90 100
FLDITASHLG RDTIVDVVKK VASKLFIPLT VGGGIRTIDD ISRLLNAGCD
110 120 130 140 150
KVSLNSSAIK DPNLIDEAAK KFGSQCVVVA IDAKKIENGY SVFINGGRID
160 170 180 190 200
TKKDAFSWAK EVESRGAGEI LLTSMDNDGV KQGFSLELTK IFSALSIPTI
210 220 230 240 250
ASGGAGKMEH FKDAFEVGAD ACLAASIFHF GEIEIKKLKE YLKANGVEVR

L
Length:251
Mass (Da):26,994
Last modified:October 23, 2007 - v1
Checksum:i512AE573E60A145F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000792 Genomic DNA Translation: EAT99046.1
RefSeqiWP_012140656.1, NC_009802.2

Genome annotation databases

EnsemblBacteriaiEAT99046; EAT99046; CCC13826_1890
KEGGicco:CCC13826_1890

Entry informationi

Entry nameiHIS6_CAMC1
AccessioniPrimary (citable) accession number: A7ZGB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 23, 2007
Last modified: June 7, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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