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Protein

Allantoinase

Gene

allB

Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes allantoate from (S)-allantoin.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Allantoinase (allB)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes allantoate from (S)-allantoin, the pathway (S)-allantoin degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc 1UniRule annotation1
Metal bindingi62Zinc 1UniRule annotation1
Metal bindingi147Zinc 1; via carbamate groupUniRule annotation1
Metal bindingi147Zinc 2; via carbamate groupUniRule annotation1
Metal bindingi183Zinc 2UniRule annotation1
Metal bindingi239Zinc 2UniRule annotation1
Metal bindingi312Zinc 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciBAMY326423:G1G84-3013-MONOMER
UniPathwayiUPA00395; UER00653

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Synonyms:pucHUniRule annotation
Ordered Locus Names:RBAM_029500
OrganismiBacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus amyloliquefaciens group
Proteomesi
  • UP000001120 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176681 – 454AllantoinaseAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA7Z8F5
SMRiA7Z8F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CD3 Bacteria
COG0044 LUCA
HOGENOMiHOG000219146
KOiK01466
OMAiHFNEPGR

Family and domain databases

Gene3Di2.30.40.10, 3 hits
HAMAPiMF_01645 Hydantoinase, 1 hit
InterProiView protein in InterPro
IPR017593 Allantoinase
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR03178 allantoinase, 1 hit

Sequencei

Sequence statusi: Complete.

A7Z8F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYDVIVKGA KAVRKGGTER ADIAVKDGKI ALIGPGIDEN AEQVVQADGM
60 70 80 90 100
YVFPGAVDCH VHFNEPGREE WEGIETGSNM LAAGGCTSYF DMPLNCIPST
110 120 130 140 150
VTAENLLAKA EIAERKSAVD FALWGGLMPG YTEHIRPMAE AGAIGFKAFL
160 170 180 190 200
SKSGTDEFQS ADERTLLKGM KEIAACGKVL ALHAESDALT RFLEAEYALQ
210 220 230 240 250
GKIDVRAYAS SRPEEAECEA VQRAIEYARA TGCALHFVHI STKRAVLSIQ
260 270 280 290 300
QAKKDGLDVT VETCPHYLLF SFEDFLKKGA AAKCAPPLRS EADKEELIGV
310 320 330 340 350
LAEGLIDMVS SDHSPCHPSL KREDNMFLSW GGISGGQFTL LGMIQLAIDH
360 370 380 390 400
GIPFEHVARW TAEAPAKRFG LTNKGRLEEG FDADFAIVRP EPFTVTKETM
410 420 430 440 450
FSKHKQSLYE GHTFPYRIAA TYSKGRCVYQ DGGRKQSGAF GTFLKPSEIK

EPIL
Length:454
Mass (Da):49,454
Last modified:October 23, 2007 - v1
Checksum:iBCA128C60A38F03C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA Translation: ABS75281.1
RefSeqiWP_012118360.1, NC_009725.1

Genome annotation databases

EnsemblBacteriaiABS75281; ABS75281; RBAM_029500
KEGGibay:RBAM_029500

Similar proteinsi

Entry informationi

Entry nameiALLB_BACVZ
AccessioniPrimary (citable) accession number: A7Z8F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: July 18, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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