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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:RBAM_028250
OrganismiBacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Taxonomic identifieri326423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus amyloliquefaciens group
Proteomesi
  • UP000001120 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei48 – 68HelicalUniRule annotationAdd BLAST21
Transmembranei92 – 112HelicalUniRule annotationAdd BLAST21
Transmembranei119 – 139HelicalUniRule annotationAdd BLAST21
Transmembranei155 – 175HelicalUniRule annotationAdd BLAST21
Transmembranei196 – 216HelicalUniRule annotationAdd BLAST21
Transmembranei229 – 249HelicalUniRule annotationAdd BLAST21
Transmembranei255 – 275HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000627871 – 276Undecaprenyl-diphosphataseAdd BLAST276

Structurei

3D structure databases

SMRiA7Z830
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OMAiVFKDRIL

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

A7Z830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLWEMFTAA VLGIVEGLTE YAPVSSTGHM IIADDIWLKS GSLMNPEAAN
60 70 80 90 100
SFKVVIQLGS ILAVAIVFKD RILHLLGLKK NVTRDQQKGY RLTIAQIAVG
110 120 130 140 150
LVPAAVLGFL FEDFIDRYLF SVRTVAYGLI AGAVLMLIAD WINKRKETID
160 170 180 190 200
TVDRITYKQA FCVGLFQCLA LWPGFSRSGS TIAGGVIVGL NHRAAADFTF
210 220 230 240 250
IMAIPIMAGA SLLKLVKYWS SLSYDMIPFF LVGFICAFVV ALLVVKFFLR
260 270
LINRIKLVPF AIYRVILGII LIMLVR
Length:276
Mass (Da):30,532
Last modified:October 23, 2007 - v1
Checksum:iB4CC505EE2E13FCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000560 Genomic DNA Translation: ABS75156.1
RefSeqiWP_007613337.1, NC_009725.1

Genome annotation databases

EnsemblBacteriaiABS75156; ABS75156; RBAM_028250
KEGGibay:RBAM_028250

Similar proteinsi

Entry informationi

Entry nameiUPPP_BACVZ
AccessioniPrimary (citable) accession number: A7Z830
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 23, 2007
Last modified: July 18, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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