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UniProtKB - A7Z4Y0 (BAEE_BACVZ)
Protein
Polyketide biosynthesis protein BaeE
Gene
baeE
Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
Status
Functioni
Probably involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. Probably has an acyl transferase activity and could also have a flavin mononucleotide-dependent oxidoreductase activity.
1 PublicationCatalytic activityi
- EC:2.3.1.39
: bacillaene biosynthesis Pathwayi
This protein is involved in the pathway bacillaene biosynthesis, which is part of Antibiotic biosynthesis.1 PublicationView all proteins of this organism that are known to be involved in the pathway bacillaene biosynthesis and in Antibiotic biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 85 | By similarity | 1 | |
Active sitei | 191 | By similarity | 1 |
GO - Molecular functioni
- [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- antibiotic biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Antibiotic biosynthesis |
Enzyme and pathway databases
BioCyci | BAMY326423:G1G84-1728-MONOMER |
UniPathwayi | UPA01003 |
Names & Taxonomyi
Protein namesi | Recommended name: Polyketide biosynthesis protein BaeEIncluding the following 1 domains: |
Gene namesi | Name:baeE Ordered Locus Names:RBAM_016930 |
Organismi | Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum) |
Taxonomic identifieri | 326423 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus amyloliquefaciens group › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000388001 | 1 – 746 | Polyketide biosynthesis protein BaeEAdd BLAST | 746 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 312 | Acyl transferaseAdd BLAST | 312 |
Sequence similaritiesi
In the N-terminal section; belongs to the FabD family.Curated
Phylogenomic databases
HOGENOMi | CLU_008708_0_0_9 |
OMAi | SIRFLMG |
Family and domain databases
CDDi | cd04742, NPD_FabD, 1 hit |
Gene3Di | 3.20.20.70, 1 hit 3.40.366.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013785, Aldolase_TIM IPR004410, Malonyl_CoA-ACP_transAc_FabD IPR016036, Malonyl_transacylase_ACP-bd IPR014179, PfaD_fam |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit |
SUPFAMi | SSF52151, SSF52151, 1 hit SSF55048, SSF55048, 1 hit |
TIGRFAMsi | TIGR00128, fabD, 1 hit TIGR02814, pfaD_fam, 1 hit |
i Sequence
Sequence statusi: Complete.
A7Z4Y0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISFVFPGQG SQRIGMGEDL FGRYPELTAK ADHILGYSIQ ELCRDGERLN
60 70 80 90 100
QTQFTQPALY VVNALSYLKK TEETGLKPDF TAGHSLGEYN ALYASGAFDF
110 120 130 140 150
EEGLQLVKKR GELMSRAKGG GMAAVIGLTH EQVTDVLREN HLDMIDIANM
160 170 180 190 200
NTPQQIVISG YKEDIEKAAS VFEAVNGVKM VHRLNVSGAF HSRYMLEAKE
210 220 230 240 250
EFSRFIESFH FKPLSIPVIS NVTARPYEQR ELKETLTGQI TGSVNWTDSI
260 270 280 290 300
RFLMGRKNMS FEEIGPGKVL TGLIQRITAE AEPITDEIKV PAEAGKSSIT
310 320 330 340 350
AASLGNEEFK RDYQLKYAYL AGGMYRGISS KEMVVKLAEK GMMGFFGTGG
360 370 380 390 400
LNIAHVEDAI LSIQHELRDG GSFGINVVHN MKHTDSEEKM IDLLLKHGIQ
410 420 430 440 450
NLEASAFLTV TPALVRFRAK GLKRGAGGQI IARQRIIAKL SRPEVAEAFL
460 470 480 490 500
SPAPDHILQK LAAENKITAE EASLMREIPV AHDICVEADS GGHTDGGVAY
510 520 530 540 550
SLMPAIIRLR DDMMKKYRYG KTVRIGAAGG IGTPEAAMAA FMLGADFIVT
560 570 580 590 600
GSINQCTVEA ATSGLVKDLL QQMNVQDTAY APAGDMFESG SKVQVLKKGL
610 620 630 640 650
FFPTRASKLH ELYQRHRSIE EIDEKTLRQI EEKYFKASVS SIYDKVKAHY
660 670 680 690 700
SNEDISKAER NPKEKMALIF KWYFRQSSAS AIKGDPDAKV DFQIHCGPAL
710 720 730 740
GAFNQWVKGT ELESWKNRHA DGIGMRLMEE TASLLNQKLG SFLQTC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000560 Genomic DNA Translation: ABS74056.1 |
RefSeqi | WP_012117591.1, NC_009725.2 |
Genome annotation databases
EnsemblBacteriai | ABS74056; ABS74056; RBAM_016930 |
KEGGi | bay:RBAM_016930 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000560 Genomic DNA Translation: ABS74056.1 |
RefSeqi | WP_012117591.1, NC_009725.2 |
3D structure databases
SMRi | A7Z4Y0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 326423.RBAM_016930 |
Genome annotation databases
EnsemblBacteriai | ABS74056; ABS74056; RBAM_016930 |
KEGGi | bay:RBAM_016930 |
Phylogenomic databases
HOGENOMi | CLU_008708_0_0_9 |
OMAi | SIRFLMG |
Enzyme and pathway databases
UniPathwayi | UPA01003 |
BioCyci | BAMY326423:G1G84-1728-MONOMER |
Family and domain databases
CDDi | cd04742, NPD_FabD, 1 hit |
Gene3Di | 3.20.20.70, 1 hit 3.40.366.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013785, Aldolase_TIM IPR004410, Malonyl_CoA-ACP_transAc_FabD IPR016036, Malonyl_transacylase_ACP-bd IPR014179, PfaD_fam |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit |
SUPFAMi | SSF52151, SSF52151, 1 hit SSF55048, SSF55048, 1 hit |
TIGRFAMsi | TIGR00128, fabD, 1 hit TIGR02814, pfaD_fam, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BAEE_BACVZ | |
Accessioni | A7Z4Y0Primary (citable) accession number: A7Z4Y0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 3, 2009 |
Last sequence update: | October 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families