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Protein

Protein phosphatase 1 regulatory subunit 37

Gene

PPP1R37

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 37
Alternative name(s):
Leucine-rich repeat-containing protein 68
Gene namesi
Name:PPP1R37
Synonyms:LRRC68
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:33241 PPP1R37

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003209381 – 699Protein phosphatase 1 regulatory subunit 37Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei566PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA7Z026
PRIDEiA7Z026

Expressioni

Gene expression databases

BgeeiENSBTAG00000018834 Expressed in 9 organ(s), highest expression level in testis

Interactioni

Subunit structurei

Interacts with PPP1CA.By similarity

Structurei

3D structure databases

ProteinModelPortaliA7Z026
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati220 – 240LRR 1Add BLAST21
Repeati248 – 269LRR 2Add BLAST22
Repeati277 – 297LRR 3Add BLAST21
Repeati306 – 326LRR 4Add BLAST21
Repeati334 – 354LRR 5Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi532 – 661Pro-richAdd BLAST130

Sequence similaritiesi

Belongs to the PPP1R37 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1908 Eukaryota
ENOG410XSTR LUCA
GeneTreeiENSGT00920000149154
HOGENOMiHOG000074153
HOVERGENiHBG108102
InParanoidiA7Z026
KOiK17576
OMAiSFIETQR
OrthoDBiEOG091G0KU7
TreeFamiTF328391

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 5 hits

Sequencei

Sequence statusi: Complete.

A7Z026-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIPPQEAPP GPGADGEAEE APVEAPSPGP ASPPADGRLK AAAKRVTFPS
60 70 80 90 100
DEDIVSGAVE PKDPWRHAQN VTVDEIIGAY KQACQKLNCR QIPKLLRQLQ
110 120 130 140 150
EFTDLGHRID CLDLKGEKLD YKTCEALEEV FKRLQFKVVD LEQTNLDEDG
160 170 180 190 200
ASALFDMIEY YESATHLNIS FNKHIGTRGW QAAAHMMRKT SCLQYLDARN
210 220 230 240 250
TPLLDHSAPF VARALRIRSS LAVLHLESSS LSGRPLMLLA TALKMNMTLR
260 270 280 290 300
ELYLADNKLN GLQDSAQLGN LLKFNCSLQI LDLRNNHVLD SGLAYICEGL
310 320 330 340 350
KEQRKGLATL VLWNNQLTHT GMAFLGMTLP HTHSLETLNL GHNPIGNEGV
360 370 380 390 400
RNLKNGLISN RSVLRLGLAS TKLTCEGAVA VAEFIAESPR LLRLDLRENE
410 420 430 440 450
IKTGGLMALS LALKVNHSLL RLDLDREPKK EAVKSFIETQ KALLAEIQNG
460 470 480 490 500
CKRNFVLVRE REEKEQRLQL SASMPEITVT EPQPDDEPRE EPAAEAQENG
510 520 530 540 550
APGPSPGPDS DSDSDSEGED RDEADGERAE APCPTLVPPT DSLGPGDRSP
560 570 580 590 600
PGCPSSPAEQ RISVSSPGWG HKVFVVTRVE SPPERAEPPV PPAPPGPVSP
610 620 630 640 650
PASASPPTSP FPTPTEAAST PDPGPPEPQP PLEPPQVGPP LPNGLKPEFA
660 670 680 690
LALSPEPPPG PEAKVGSCGL EHELSCSKNE KELEELLLEA SQESGQETL
Length:699
Mass (Da):75,697
Last modified:October 23, 2007 - v1
Checksum:iB3C19171B2DFF3C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC153224 mRNA Translation: AAI53225.1
RefSeqiNP_001098849.1, NM_001105379.1
UniGeneiBt.62290

Genome annotation databases

EnsembliENSBTAT00000025071; ENSBTAP00000025071; ENSBTAG00000018834
GeneIDi516932
KEGGibta:516932

Similar proteinsi

Entry informationi

Entry nameiPPR37_BOVIN
AccessioniPrimary (citable) accession number: A7Z026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 23, 2007
Last modified: September 12, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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