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Entry version 81 (07 Apr 2021)
Sequence version 1 (23 Oct 2007)
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Protein

Glutamate receptor ionotropic, NMDA 2B

Gene

grin2b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:18177891, PubMed:25008524, PubMed:28232581). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable).Curated3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei511Glutamate1 Publication1
Binding sitei516GlutamateBy similarity1
Binding sitei729GlutamateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • NMDA glutamate receptor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandCalcium, Magnesium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 2B
Short name:
GluN2B
Alternative name(s):
N-methyl D-aspartate receptor subtype 2B
Short name:
NMDAR2B
Short name:
NR2B1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:grin2b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000186698 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 4s, Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 554Extracellular1 PublicationAdd BLAST530
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei555 – 573Helical1 PublicationAdd BLAST19
Topological domaini574 – 600Cytoplasmic1 PublicationAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei601 – 620Discontinuously helical1 PublicationAdd BLAST20
Topological domaini621 – 627Cytoplasmic1 Publication7
Transmembranei628 – 643Helical1 PublicationAdd BLAST16
Topological domaini644 – 819Extracellular1 PublicationAdd BLAST176
Transmembranei820 – 839HelicalBy similarityAdd BLAST20
Topological domaini840 – 1448Cytoplasmic1 PublicationAdd BLAST609

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501082110425 – 1448Glutamate receptor ionotropic, NMDA 2BSequence analysisAdd BLAST1424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi81 ↔ 316Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi336N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Disulfide bondi426 ↔ 453Combined sources2 Publications
Disulfide bondi433 ↔ 454Combined sources2 Publications
Glycosylationi685N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Disulfide bondi743 ↔ 798Combined sources2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A7XY94

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in oocytes.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (grin1), and two epsilon subunits (grin2a, grin2b, grin2c or grin2d) (in vitro) (PubMed:18177891, PubMed:25008524, PubMed:27062927, PubMed:28232581). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable).

Curated4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61037N

Protein interaction database and analysis system

More...
IntActi
A7XY94, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A7XY94

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni601 – 620Pore-forming1 PublicationAdd BLAST20
Regioni687 – 688Glutamate bindingBy similarity2

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
SREVYSC

Database of Orthologous Groups

More...
OrthoDBi
188544at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR019594, Glu/Gly-bd
IPR001508, Iono_rcpt_met
IPR001320, Iontro_rcpt
IPR018884, NMDAR2_C
IPR028082, Peripla_BP_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01094, ANF_receptor, 1 hit
PF00060, Lig_chan, 1 hit
PF10613, Lig_chan-Glu_bd, 1 hit
PF10565, NMDAR2_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00177, NMDARECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00918, Lig_chan-Glu_bd, 1 hit
SM00079, PBPe, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822, SSF53822, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A7XY94-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPTEACCYL KISLIILFYM GCYAQKHPNM DIAVILVGTT EEVAIKDVHE
60 70 80 90 100
KDDFHHLPVT PRVALVTMNE SDPKSIITRI CDLMSDKKVQ GVVFGDDTDQ
110 120 130 140 150
EAIAQILDFI SVQTLTPILG IHGGSSMIMA DKEEASMFFQ FGPSIEQQAS
160 170 180 190 200
VMLNIMEEYD WYIFSIVTTY FPGYQDFENK VRSTIENSFV GWELEEVIHL
210 220 230 240 250
DMSLDDIDSK IQNQLKKLQS PVILLYCTKE EATYIFEVAH SVGLTGYGFT
260 270 280 290 300
WIVPSLVAGD TDTVPDEFPT GLISVSYDEW DYDLPARVRD GIAIITTAAS
310 320 330 340 350
TMLSEHNSIP QSKSSCNNIQ ESRVYEAHML KRYLINVTFE GRNLSFSEDG
360 370 380 390 400
YQMHPKLVII LLNQERKWER VGKYKDRSLK MKYYVWPVFD LYPNSEEHKD
410 420 430 440 450
EHLSIVTLEE APFVIVEDVD PLSGTCMRNT VPCRKQIRPE NRTEEGGNYI
460 470 480 490 500
KRCCKGFCID ILKKIAKTVK FTYDLYLVTN GKHGKKINGT WNGMIGEVVT
510 520 530 540 550
KRAYMAVGSL TINEERSEVV DFSVPFIETG ISVMVSRSNG TVSPSAFLEP
560 570 580 590 600
FSADVWVMMF VMLLIVSAVA VFVFEYFSPV GYNRCLADGR EPGGPSFTIG
610 620 630 640 650
KAIWLLWGLV FNNSVPVQNP KGTTSKIMVS VWAFFAVIFL ASYTANLAAF
660 670 680 690 700
MIQEEYVDQV SGLSDKKFQR PNDFSPAFRF GTVPNGSTER NIRNNYLEMH
710 720 730 740 750
SYMVKFNQRS VQDALLSLKS GKLDAFIYDA AVLNYMAGRD EGCKLVTIGS
760 770 780 790 800
GKVFATTGYG IAIQKDSGWK RQVDLAILQL FGDGEMEELE ALWLTGICHN
810 820 830 840 850
EKNEVMSSQL DIDNMAGVFY MLAAAMALSL ITFIMEHLFF WQLRHCFMGV
860 870 880 890 900
CSGKPGMVFS ISRGIYSCIH GVAIEDRQSA LDSPSATMNN THSNILRLLR
910 920 930 940 950
TAKNMANLSG VNGSPQSALD FIRRESSVYD ISEHRRSFTH SDCKSFQPEE
960 970 980 990 1000
NLFSDYISEV ERTFGNLQLK DSNVYQDHFH HHRPHSIGSN SSIDGLYDCD
1010 1020 1030 1040 1050
NAPFTTQPRS LSKKPLDIGL PSKHPSPQIG DLYGKFSFKS DHYGAPDDLI
1060 1070 1080 1090 1100
RSDVSDISTH TVTYGNIEGN AKRRKQYKDS LKKRPASAKS RREFDEIELA
1110 1120 1130 1140 1150
YRRRQRSPDH KRYFRDKEGL RDFYLDQFRT KENNPHWEHV DLTHIYAERA
1160 1170 1180 1190 1200
DDFKHDTSCS NRQHQKHVGE FVQTDRKHGS GGNAWEKNMS NIEWEDRASS
1210 1220 1230 1240 1250
NFCRNCPSKM HNYTGQNTNR PACIRCEVCK KAGNLYDISE DNSLQDLEAR
1260 1270 1280 1290 1300
PIQAPNSKYP QSPNGKAQKR NRSKLHRQHS YDTFVDLQKE DVTLAPRSVS
1310 1320 1330 1340 1350
LKDKERFLDG SPYAHMFEMP NETSFTSKSH GPTHNPGGYM LSRSLYPDRV
1360 1370 1380 1390 1400
TQNPFIPTFG DDQCLLHGSK PYYFRQPAIG GLKGRADFRG AGKSLSAQHS
1410 1420 1430 1440
GPSGHFQKDI CIGNQPNACV SNNKNPRSFN NSTNGHVYEK LSSIESDV
Length:1,448
Mass (Da):163,913
Last modified:October 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBF9301FEE749D5D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU104357 mRNA Translation: ABU84989.1
CM004473 Genomic DNA Translation: OCT82994.1

NCBI Reference Sequences

More...
RefSeqi
NP_001104191.1, NM_001110721.1
XP_018114751.1, XM_018259262.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100126610

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:100126610

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU104357 mRNA Translation: ABU84989.1
CM004473 Genomic DNA Translation: OCT82994.1
RefSeqiNP_001104191.1, NM_001110721.1
XP_018114751.1, XM_018259262.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4TLLX-ray3.59B/D20-839[»]
4TLMX-ray3.77B/D20-839[»]
5IOUelectron microscopy7.00B/D1-839[»]
5IOVelectron microscopy7.50B/D1-839[»]
5IPQelectron microscopy13.50B/D1-839[»]
5IPRelectron microscopy14.10B/D1-839[»]
5IPSelectron microscopy13.50B/D1-839[»]
5IPTelectron microscopy14.10B/D1-839[»]
5IPUelectron microscopy15.40B/D1-839[»]
5IPVelectron microscopy9.25B/D1-839[»]
5UN1X-ray3.60B/D/F/H400-839[»]
5UOWelectron microscopy4.50D1-840[»]
5UP2electron microscopy6.00D1-840[»]
SMRiA7XY94
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-61037N
IntActiA7XY94, 1 interactor

PTM databases

iPTMnetiA7XY94

Genome annotation databases

GeneIDi100126610
KEGGixla:100126610

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100126610

Phylogenomic databases

OMAiSREVYSC
OrthoDBi188544at2759

Family and domain databases

InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR019594, Glu/Gly-bd
IPR001508, Iono_rcpt_met
IPR001320, Iontro_rcpt
IPR018884, NMDAR2_C
IPR028082, Peripla_BP_I
PfamiView protein in Pfam
PF01094, ANF_receptor, 1 hit
PF00060, Lig_chan, 1 hit
PF10613, Lig_chan-Glu_bd, 1 hit
PF10565, NMDAR2_C, 1 hit
PRINTSiPR00177, NMDARECEPTOR
SMARTiView protein in SMART
SM00918, Lig_chan-Glu_bd, 1 hit
SM00079, PBPe, 1 hit
SUPFAMiSSF53822, SSF53822, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNMDE2_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7XY94
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2017
Last sequence update: October 23, 2007
Last modified: April 7, 2021
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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