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Entry version 110 (26 Feb 2020)
Sequence version 1 (23 Oct 2007)
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Protein

TNF receptor-associated factor 6

Gene

TRAF6

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri71 – 110RING-type; degeneratePROSITE-ProRule annotationAdd BLAST40
Zinc fingeri151 – 203TRAF-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri204 – 260TRAF-type 2PROSITE-ProRule annotationAdd BLAST57

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processDNA damage, Immunity, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-SSC-168638 NOD1/2 Signaling Pathway
R-SSC-193692 Regulated proteolysis of p75NTR
R-SSC-202424 Downstream TCR signaling
R-SSC-209543 p75NTR recruits signalling complexes
R-SSC-209560 NF-kB is activated and signals survival
R-SSC-2871837 FCERI mediated NF-kB activation
R-SSC-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-SSC-450302 activated TAK1 mediates p38 MAPK activation
R-SSC-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-SSC-5607764 CLEC7A (Dectin-1) signaling
R-SSC-5689880 Ub-specific processing proteases
R-SSC-5689896 Ovarian tumor domain proteases
R-SSC-9020702 Interleukin-1 signaling
R-SSC-937039 IRAK1 recruits IKK complex
R-SSC-937041 IKK complex recruitment mediated by RIP1
R-SSC-937042 IRAK2 mediated activation of TAK1 complex
R-SSC-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-SSC-9645460 Alpha-protein kinase 1 signaling pathway
R-SSC-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-SSC-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-SSC-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-SSC-975155 MyD88 dependent cascade initiated on endosome
R-SSC-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-SSC-975871 MyD88 cascade initiated on plasma membrane

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TNF receptor-associated factor 6 (EC:2.3.2.27)
Alternative name(s):
E3 ubiquitin-protein ligase TRAF6
RING-type E3 ubiquitin transferase TRAF6Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAF6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2
  • UP000008227 Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lipid droplet, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Osteopetrosis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003916101 – 541TNF receptor-associated factor 6Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki143Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated on Lys-125, Lys-143 and Lys-472 with SUMO1.By similarity
Polyubiquitinated; after cell stimulation with IL-1-beta or TGF-beta. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form. Deubiquitinated by USP10 in a TANK-dependent manner, leading to the negative regulation of NF-kappaB signaling upon DNA damage.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A7XUJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000013291 Expressed in heart and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A7XUJ6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (By similarity). Homooligomer (By similarity). N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK2, IRAK3, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2.

Interacts with IL17R.

Interacts with SQSTM1 bridging NTRK1 and NGFR.

Forms a ternary complex with SQSTM1 and PRKCZ.

Interacts with PELI2 and PELI3. Binds UBE2V1.

Interacts with MAVS/IPS1.

Interacts with TAX1BP1.

Interacts with IL1RL1.

Interacts with TRAFD1.

Interacts with ZNF675.

Interacts with AJUBA.

Interacts with TICAM2.

Interacts with ZFAND5.

Interacts with ARRB1 and ARRB2.

Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling.

Interacts with UBE2N.

Interacts with TGFBR1, HDAC1 and RANGAP1.

Interacts with AKT1, AKT2 and AKT3.

Interacts (via TRAF domains) with NUMBL (via C-terminal).

Interacts (via TRAF domains) with WDR34 (via WD domains).

Interacts with RBCK1 (By similarity).

Interacts with TRAF3IP2 (By similarity).

Interacts with LIMD1 (via LIM domains) (By similarity).

Interacts with RSAD2/viperin (By similarity).

Interacts with IFIT3 (via N-terminus) (By similarity).

Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain).

Interacts with CARD14 (By similarity).

Interacts with CD40 and MAP3K8; the interaction is required for ERK activation.

Interacts with TICAM1 and this interaction is enhanced in the presence of WDFY1 (By similarity).

Interacts with TANK; this interaction increases in response to DNA damage (By similarity).

Interacts with USP10; this interaction increases in response to DNA damage (By similarity).

Interacts with ZC3H12A; this interaction increases in response to DNA damage and is stimulated by TANK (By similarity).

Interacts with WDFY3 (By similarity).

Interacts with TRIM13 (By similarity).

Interacts with GPS2 (By similarity).

Interacts (via C-terminus) with SASH1 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000029003

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A7XUJ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini369 – 518MATHPROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 373Interaction with TAX1BP1By similarityAdd BLAST373
Regioni374 – 541Interaction with TANKBy similarityAdd BLAST168

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili312 – 367Sequence analysisAdd BLAST56

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled coil domain mediates homo- and hetero-oligomerization.By similarity
The MATH/TRAF domain binds to receptor cytoplasmic domains.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri71 – 110RING-type; degeneratePROSITE-ProRule annotationAdd BLAST40
Zinc fingeri151 – 203TRAF-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri204 – 260TRAF-type 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISDW Eukaryota
ENOG410XTXK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155426

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_021061_5_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A7XUJ6

KEGG Orthology (KO)

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KOi
K03175

Identification of Orthologs from Complete Genome Data

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OMAi
ECAICID

Database of Orthologous Groups

More...
OrthoDBi
918518at2759

TreeFam database of animal gene trees

More...
TreeFami
TF321154

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03776 MATH_TRAF6, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.210.10, 1 hit
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002083 MATH/TRAF_dom
IPR012227 TNF_rcpt--assoc_TRAF
IPR008974 TRAF-like
IPR027139 TRAF6
IPR037309 TRAF6_MATH
IPR041310 TRAF6_Z2
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
IPR001293 Znf_TRAF

The PANTHER Classification System

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PANTHERi
PTHR10131:SF131 PTHR10131:SF131, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF18048 TRAF6_Z2, 1 hit
PF02176 zf-TRAF, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF015614 TRAF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00061 MATH, 1 hit
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49599 SSF49599, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50144 MATH, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
PS50145 ZF_TRAF, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A7XUJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLLHCENSC GSSQSESDCC AAMAASSCGA AAKDDGVSGT ASTGNLSSSF
60 70 80 90 100
MEEIQGYDVE FDPPLESKYE CPICLMALRE AVQTPCGHRF CKACIIKSIR
110 120 130 140 150
DAGHKCPVDN EILLENQLFP DNFAKREILS LTVKCPNVGC LHKMELRHLE
160 170 180 190 200
DHQAHCEFAL MNCPQCQRPF QKCQLNIHIL KECPRRQVSC VNCAVSMAFE
210 220 230 240 250
DKEIHDQNCP LANVICEYCN TVLIREQMPN HYDLDCPTAP VPCTFSTFGC
260 270 280 290 300
HEKMQRNHLA RHLQENTQSH MRMMAQALQG LSLAVAPVPQ RDMLPYDSSP
310 320 330 340 350
LSRISSGCCS DQNFQETIQQ LEGRLVRQDH QIRELTAKME TQSMYVSELK
360 370 380 390 400
RTIRSLEDKV AEIEAQQCNG IYIWKIGNFG MHLKSQEEEK PVVIHSPGFY
410 420 430 440 450
TGKPGYKLCM RLHLQLPTAQ RCANYISLFV HTMQGEYDSH LPWPFQGTIR
460 470 480 490 500
LTILDQSEAP IRQNHEEIMD AKPELLAFQR PTIPRNPKGF GYVTFMHLDA
510 520 530 540
LRQRTFIKDD TLLVRCEVST RFDMGSLRRE GFQPRSTDSG T
Length:541
Mass (Da):61,266
Last modified:October 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCA939106D3476BE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5G2QUR0A0A5G2QUR0_PIG
TNF receptor-associated factor
TRAF6
517Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5G2RK02A0A5G2RK02_PIG
TNF receptor-associated factor
TRAF6
526Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
EU095967 mRNA Translation: ABU75303.1

NCBI Reference Sequences

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RefSeqi
NP_001098756.1, NM_001105286.1
XP_005652858.1, XM_005652801.1
XP_013845523.1, XM_013990069.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000038108; ENSSSCP00000034114; ENSSSCG00000038082
ENSSSCT00025072870; ENSSSCP00025031583; ENSSSCG00025053171
ENSSSCT00040020989; ENSSSCP00040008813; ENSSSCG00040015563
ENSSSCT00045010582; ENSSSCP00045007210; ENSSSCG00045006364
ENSSSCT00050070036; ENSSSCP00050030107; ENSSSCG00050051437
ENSSSCT00055029378; ENSSSCP00055023384; ENSSSCG00055014879
ENSSSCT00060033021; ENSSSCP00060014161; ENSSSCG00060024340
ENSSSCT00070002699; ENSSSCP00070002244; ENSSSCG00070001436
ENSSSCT00070002709; ENSSSCP00070002254; ENSSSCG00070001436

Database of genes from NCBI RefSeq genomes

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GeneIDi
396629

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ssc:396629

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU095967 mRNA Translation: ABU75303.1
RefSeqiNP_001098756.1, NM_001105286.1
XP_005652858.1, XM_005652801.1
XP_013845523.1, XM_013990069.1

3D structure databases

SMRiA7XUJ6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000029003

Proteomic databases

PaxDbiA7XUJ6

Genome annotation databases

EnsembliENSSSCT00000038108; ENSSSCP00000034114; ENSSSCG00000038082
ENSSSCT00025072870; ENSSSCP00025031583; ENSSSCG00025053171
ENSSSCT00040020989; ENSSSCP00040008813; ENSSSCG00040015563
ENSSSCT00045010582; ENSSSCP00045007210; ENSSSCG00045006364
ENSSSCT00050070036; ENSSSCP00050030107; ENSSSCG00050051437
ENSSSCT00055029378; ENSSSCP00055023384; ENSSSCG00055014879
ENSSSCT00060033021; ENSSSCP00060014161; ENSSSCG00060024340
ENSSSCT00070002699; ENSSSCP00070002244; ENSSSCG00070001436
ENSSSCT00070002709; ENSSSCP00070002254; ENSSSCG00070001436
GeneIDi396629
KEGGissc:396629

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7189

Phylogenomic databases

eggNOGiENOG410ISDW Eukaryota
ENOG410XTXK LUCA
GeneTreeiENSGT00940000155426
HOGENOMiCLU_021061_5_0_1
InParanoidiA7XUJ6
KOiK03175
OMAiECAICID
OrthoDBi918518at2759
TreeFamiTF321154

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-SSC-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-SSC-168638 NOD1/2 Signaling Pathway
R-SSC-193692 Regulated proteolysis of p75NTR
R-SSC-202424 Downstream TCR signaling
R-SSC-209543 p75NTR recruits signalling complexes
R-SSC-209560 NF-kB is activated and signals survival
R-SSC-2871837 FCERI mediated NF-kB activation
R-SSC-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-SSC-450302 activated TAK1 mediates p38 MAPK activation
R-SSC-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-SSC-5607764 CLEC7A (Dectin-1) signaling
R-SSC-5689880 Ub-specific processing proteases
R-SSC-5689896 Ovarian tumor domain proteases
R-SSC-9020702 Interleukin-1 signaling
R-SSC-937039 IRAK1 recruits IKK complex
R-SSC-937041 IKK complex recruitment mediated by RIP1
R-SSC-937042 IRAK2 mediated activation of TAK1 complex
R-SSC-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-SSC-9645460 Alpha-protein kinase 1 signaling pathway
R-SSC-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-SSC-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-SSC-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-SSC-975155 MyD88 dependent cascade initiated on endosome
R-SSC-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-SSC-975871 MyD88 cascade initiated on plasma membrane

Gene expression databases

BgeeiENSSSCG00000013291 Expressed in heart and 5 other tissues
ExpressionAtlasiA7XUJ6 baseline and differential

Family and domain databases

CDDicd03776 MATH_TRAF6, 1 hit
Gene3Di2.60.210.10, 1 hit
3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR002083 MATH/TRAF_dom
IPR012227 TNF_rcpt--assoc_TRAF
IPR008974 TRAF-like
IPR027139 TRAF6
IPR037309 TRAF6_MATH
IPR041310 TRAF6_Z2
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
IPR001293 Znf_TRAF
PANTHERiPTHR10131:SF131 PTHR10131:SF131, 1 hit
PfamiView protein in Pfam
PF18048 TRAF6_Z2, 1 hit
PF02176 zf-TRAF, 1 hit
PIRSFiPIRSF015614 TRAF, 1 hit
SMARTiView protein in SMART
SM00061 MATH, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF49599 SSF49599, 3 hits
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
PS50145 ZF_TRAF, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRAF6_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7XUJ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: October 23, 2007
Last modified: February 26, 2020
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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