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Entry version 72 (02 Jun 2021)
Sequence version 1 (23 Oct 2007)
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Protein
Submitted name:

Multidrug resistance-associated protein 2

Gene

mrp2

Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi822 – 829ATPPROSITE-ProRule annotation8
Nucleotide bindingi1894 – 1901ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.208.26, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Multidrug resistance-associated protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mrp2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5833 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei132 – 160HelicalSequence analysisAdd BLAST29
Transmembranei180 – 203HelicalSequence analysisAdd BLAST24
Transmembranei402 – 428HelicalSequence analysisAdd BLAST27
Transmembranei434 – 453HelicalSequence analysisAdd BLAST20
Transmembranei521 – 539HelicalSequence analysisAdd BLAST19
Transmembranei1427 – 1453HelicalSequence analysisAdd BLAST27
Transmembranei1473 – 1495HelicalSequence analysisAdd BLAST23
Transmembranei1549 – 1568HelicalSequence analysisAdd BLAST20
Transmembranei1574 – 1592HelicalSequence analysisAdd BLAST19
Transmembranei1654 – 1676HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini405 – 580ABC transmembrane type-1InterPro annotationAdd BLAST176
Domaini788 – 1014ABC transporterInterPro annotationAdd BLAST227
Domaini1429 – 1672ABC transmembrane type-1InterPro annotationAdd BLAST244
Domaini1862 – 2130ABC transporterInterPro annotationAdd BLAST269

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni239 – 272DisorderedSequence analysisAdd BLAST34
Regioni284 – 308DisorderedSequence analysisAdd BLAST25
Regioni963 – 1035DisorderedSequence analysisAdd BLAST73
Regioni1178 – 1227DisorderedSequence analysisAdd BLAST50
Regioni1749 – 1791DisorderedSequence analysisAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili363 – 387Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi239 – 257Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi970 – 1035Polar residuesSequence analysisAdd BLAST66
Compositional biasi1185 – 1227Polar residuesSequence analysisAdd BLAST43
Compositional biasi1749 – 1778Polar residuesSequence analysisAdd BLAST30

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664, ABC_membrane, 1 hit
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A7XLD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMRRRSVYNF DQGKHGYLMN HISWLNFVSF NWITQLLRCL KNDDFVLPCI
60 70 80 90 100
EETSSIEHYS TNLNRNVRNI QLRKYNKYNK YKNYCCSKYN DGNKSCSCST
110 120 130 140 150
KNHTNKFHKR KKEDHFLKSS GITYAVLKTF KYYLSLISFF HIIHTIFLIF
160 170 180 190 200
VAVCIEKYVL LIKGGSNVVT LPFGFKNSKV LFGFIVISVI FISQFFDALL
210 220 230 240 250
CYYDFRLRVN MEVTVMYFLY KITLGNFNNQ LINRNDIYDD HSEEGKGQHK
260 270 280 290 300
NQCQYDENDQ NDENDQNDQN EQSDLRDIRH MHDKHVKHND EESKDSTNST
310 320 330 340 350
TYIKNNNNQM SHINDLSITN NMSDVHILSS IKNQDQNNSN NVSSMDSNTN
360 370 380 390 400
YMSKTTCLTC TGSEFNKEEK DEKKELLEEA KKKDKEVFDI SIYNIMFIDT
410 420 430 440 450
PFLIYFITAL IELANMIIKF IMSFYMFYYK MGSAAVLNGA LLIIIMYGLM
460 470 480 490 500
FAFEFSSSLF KLKYLKYRDT RISNMHHILK EFKLMKIFNW ESIAFDYVNM
510 520 530 540 550
FRIKEMKICK IRTYLSSLSN YVNNISVNIV EVAIFFFYIR SELKSNKTVS
560 570 580 590 600
FSSLITPLFV YKSLISGVSN FPNIINNLIE GAINIKRINK YINYYLFNND
610 620 630 640 650
MNDYFKNSLN GMKSNTCNFQ NGNTNNVNGY VDDYVDGYVD DYVDDYVNDY
660 670 680 690 700
VDDYVNDYVD DYVNDYVDDY VNDYVDDYVD DYMDHMMEYN ININSKNGCS
710 720 730 740 750
SKSRKNNKSF SKDHFSNHEQ GTMQSFYKFL DTHKNKTKQK SDCIKKCSNN
760 770 780 790 800
QLSKSNNNNV VGESNNSLFQ DRKGWYPKNK HFKDNIVINM KNCYFSSKNN
810 820 830 840 850
DDYILKNINL TLKNNSVVII LGNVGSGKTI FFYSLLGQFK LSCGSFYLKN
860 870 880 890 900
YIYKYMPILY VPQFNWISLG TIRSMILFGN KYDESIYYDV IVKSELFHDI
910 920 930 940 950
ISFKKKDMRY ISDEHSLSKG QKARICLARA LYHHYIHMKH MNLYYQKNEL
960 970 980 990 1000
INEKMKKISL KRDDNHTAQR SNDNTPNNNN TDNNNTSDNN NTSNNNNTSD
1010 1020 1030 1040 1050
NNNTSDNNNT SDNNNTSNNN NTDNNNTSNN KNSCSKNLTE ERNISYLYLF
1060 1070 1080 1090 1100
DDLFTSLDPC ISKDIFYNLF CDKEKIQHFK KNSSFILSIS EIILNSFISS
1110 1120 1130 1140 1150
NCILNNMQYD VLIYKLENST LHYEGNLVDY IKKNNIVVKE DIVQTNKQCE
1160 1170 1180 1190 1200
KKSLTNEQVK SMLSLNEDWN YMHRVKKKSI TQKETTKNYD NNNDNNNDNN
1210 1220 1230 1240 1250
NDNNNDNNND NNNNNNNDNN NNNNNNVNVS KEILSCEIKT QDHYNNIHCS
1260 1270 1280 1290 1300
KTNFEKHNNS IYSKKENETR KIHSGDIKYH KFMVLKQFKT IYSFKTIYSF
1310 1320 1330 1340 1350
NTEETNDDEY NKTYYRKYTK VIQNYDNHCL EGKKKSFRNY KSINSYNEIL
1360 1370 1380 1390 1400
IKENMKVWED DTYYGNDYID EYEKIKKNVL SKLKYNYYIS CDYNNSDHFD
1410 1420 1430 1440 1450
FNEELKFKGN IKLETFWWYL KKIGRPLIIV IIIFMLLSIF TDEIKNLILF
1460 1470 1480 1490 1500
LASTILKSGD KKDEEILNQQ LVYLNYFILL PSISLLTTLI SFMLIAHGIV
1510 1520 1530 1540 1550
KSAIKVHTEV LLSILYAPIH AFYSNNLGNI INKFITDVNI LDNGIIKRIY
1560 1570 1580 1590 1600
KTFYTIFRFL FTLFLLIYMV KYTIVIFPFI MLIIYFFVFN KYSKGCKEAQ
1610 1620 1630 1640 1650
RGFLASHAPL CTIYSNTIIG KDVINLYKKN NYFLTLYKQK IFDFRNYTIF
1660 1670 1680 1690 1700
KWSITIWASL YVQLIVLALT FFYIIYPHFF FKHAKQDHEI NYEKEASTIG
1710 1720 1730 1740 1750
YCITFSCSLG FVIKSLLYDY THVEKEMCST QRLEECSKMI KDEGYSDDNI
1760 1770 1780 1790 1800
TLQNNDPTHE DNNNNNNNNN NEQDANLFKS VPGSYDPNDK ENMRKYKTEI
1810 1820 1830 1840 1850
VNNTKDMYSI INKDDMLTHS INNKNNKLKK LYTSPHIDIN KIKYGICFER
1860 1870 1880 1890 1900
VFVSYKKKIC VDRKNNKYEY VNEKSCLKNI NIYALKNQKI GIVGKSGAGK
1910 1920 1930 1940 1950
STMILSILGL IGTTRGRITI EGQDIKTLTL DERKNMIGVL PQSSFVFFHW
1960 1970 1980 1990 2000
NIRTFIDPYK DFTDDEIVDA FKLIGINLSY DDLDKYIYKQ QRQQQKKKNK
2010 2020 2030 2040 2050
NTHNLWKKKS FIDLTNSISL SDECIRYLSL VRLFLNRHKY KLILIDEIPV
2060 2070 2080 2090 2100
LNFCYNTKKL TNFFTTDIKS FDYIIRTFFQ NTTVLIIAHD ASTLSCCDFI
2110 2120 2130
YVIAKGEVVY KCSYKDVKTQ TELANLLQEK QLN
Length:2,133
Mass (Da):251,339
Last modified:October 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i223C70274A8D0638
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF523383 mRNA Translation: ABV24501.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF523383 mRNA Translation: ABV24501.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi3.A.1.208.26, the atp-binding cassette (abc) superfamily

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00664, ABC_membrane, 1 hit
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA7XLD6_PLAFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7XLD6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 2, 2021
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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