Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Histocompatibility 2, M region locus 5

Gene

H2-M5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: GO_Central
  • signaling receptor binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-1236977 Endosomal/Vacuolar pathway
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-6798695 Neutrophil degranulation
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Submitted name:
Histocompatibility 2, M region locus 5Imported
Submitted name:
MHC classIb protein M5Imported
Gene namesi
Name:H2-M5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95917 H2-M5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei308 – 331HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501508658220 – 348Sequence analysisAdd BLAST329

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000024459 Expressed in 21 organ(s), highest expression level in bone marrow

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131365

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 298Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118960
HOGENOMiHOG000296917
HOVERGENiHBG016709
KOiK06751
OrthoDBiEOG091G09OH
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A7VMS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSPALSTLL SLLLTGALAL TLVRAGIHSL QFFATTMTQP GLREHSFIFV
60 70 80 90 100
VFVDDTQFLC YNNKGKNQRM EPRALWVKQM GPEYWEQQTR TVKVIEKIAL
110 120 130 140 150
VNLQEAMDIY NHSKDGSHVF QCVYGCEVGP DGLFLRGHEK HAYDGRDYLT
160 170 180 190 200
LSPDLHSWVA GDTAAQITLR RWEKSGVSEQ RQSFLKGECV ESLRTYLEIG
210 220 230 240 250
KETLLRTDPP KAHVTHHPRP EGEVTLRCWA LGFYPANIIL TWQWDEEDLT
260 270 280 290 300
QDMDLIETRP AGDGTFQKWA SVVVPSGEEQ RYTCHVQHEG LTQPLVLKWD
310 320 330 340
PSKHTIPIMG ITVGLLLFGV VFTGAVVAIV MRKRKGFQII ILKTFLKG
Length:348
Mass (Da):39,478
Last modified:October 23, 2007 - v1
Checksum:i5C94A264BF0C5A1C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJA9H3BJA9_MOUSE
Histocompatibility 2, M region locu...
H2-M5
318Annotation score:
H3BK58H3BK58_MOUSE
Histocompatibility 2, M region locu...
H2-M5
327Annotation score:
F6VXI7F6VXI7_MOUSE
Histocompatibility 2, M region locu...
H2-M5
138Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR956641 Genomic DNA No translation available.
AB359228 mRNA Translation: BAF76148.1
RefSeqiNP_001108547.1, NM_001115075.1
UniGeneiMm.246609

Genome annotation databases

EnsembliENSMUST00000169189; ENSMUSP00000131365; ENSMUSG00000024459
GeneIDi240095
KEGGimmu:240095
UCSCiuc008clt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR956641 Genomic DNA No translation available.
AB359228 mRNA Translation: BAF76148.1
RefSeqiNP_001108547.1, NM_001115075.1
UniGeneiMm.246609

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131365

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169189; ENSMUSP00000131365; ENSMUSG00000024459
GeneIDi240095
KEGGimmu:240095
UCSCiuc008clt.1 mouse

Organism-specific databases

CTDi240095
MGIiMGI:95917 H2-M5

Phylogenomic databases

GeneTreeiENSGT00760000118960
HOGENOMiHOG000296917
HOVERGENiHBG016709
KOiK06751
OrthoDBiEOG091G09OH
TreeFamiTF336617

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-1236977 Endosomal/Vacuolar pathway
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-6798695 Neutrophil degranulation
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024459 Expressed in 21 organ(s), highest expression level in bone marrow

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA7VMS3_MOUSE
AccessioniPrimary (citable) accession number: A7VMS3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again