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Protein

Calcium-activated potassium channel subunit beta-3

Gene

Kcnmb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. May partially inactivate the current of KCNBMA. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-1296052 Ca2+ activated K+ channels

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-3
Alternative name(s):
Calcium-activated potassium channel subfamily M subunit beta-3
Maxi K channel subunit beta-3
Gene namesi
Name:Kcnmb3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1311852 Kcnmb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 197ExtracellularSequence analysisAdd BLAST125
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 239CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003125951 – 239Calcium-activated potassium channel subunit beta-3Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
The extracellular domain contains disulfide bond essential for the gating mechanism.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA7VL23
PRIDEiA7VL23

Expressioni

Gene expression databases

BgeeiENSRNOG00000027836

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055650

Structurei

3D structure databases

SMRiA7VL23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF7H Eukaryota
ENOG410YQCT LUCA
GeneTreeiENSGT00390000015997
HOGENOMiHOG000290180
HOVERGENiHBG108059
InParanoidiA7VL23
KOiK04939
OMAiVFHCLFW
OrthoDBiEOG091G0MVO
PhylomeDBiA7VL23
TreeFamiTF328589

Family and domain databases

InterProiView protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu
PANTHERiPTHR10258 PTHR10258, 1 hit
PfamiView protein in Pfam
PF03185 CaKB, 1 hit

Sequencei

Sequence statusi: Complete.

A7VL23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPFSIPVQI TLQGGRRRQG RTALPASGIS NGDPLKVHPK LPSSAGEDRA
60 70 80 90 100
TLLGIAMMAS SVLMFFLLGT TVLKPFMLSS PREESNCTTV HTHIADDWLD
110 120 130 140 150
FAFTCEGSCQ GQGTYPCLQV FVNLSHSGQK VLLHYDEEAI RTNPKCFYTP
160 170 180 190 200
KCHGDRDHLL NSALDIKEFF DHNNGTFPCF YSPDGPLGVV LRKSGHKVVF
210 220 230
HCLFWPLLTL LGGALIVGLV RLTQHLSFQC EKYRAVVRA
Length:239
Mass (Da):26,447
Last modified:October 23, 2007 - v1
Checksum:i090A87142030B2FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB297662 mRNA Translation: BAF79924.1
RefSeqiNP_001098030.1, NM_001104560.2
UniGeneiRn.218452

Genome annotation databases

EnsembliENSRNOT00000058860; ENSRNOP00000055650; ENSRNOG00000027836
GeneIDi310303
KEGGirno:310303
UCSCiRGD:1311852 rat

Similar proteinsi

Entry informationi

Entry nameiKCMB3_RAT
AccessioniPrimary (citable) accession number: A7VL23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 23, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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