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UniProtKB - A7UKX9 (A7UKX9_HUMAN)
Protein
Submitted name:
Mdm2
Gene
mdm2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- negative regulation of apoptotic process Source: InterPro
- negative regulation of transcription by RNA polymerase II Source: InterPro
- protein ubiquitination Source: InterPro
- regulation of cell cycle Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Mdm2Imported |
Gene namesi | Name:mdm2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleus Source: InterPro
Keywords - Cellular componenti
NucleusARBA annotationStructurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 82 – 104 | DisorderedSequence analysisAdd BLAST | 23 |
Keywords - Domaini
Zinc-fingerARBA annotationFamily and domain databases
Gene3Di | 1.10.245.10, 1 hit |
InterProi | View protein in InterPro IPR015459, MDM2_E3_ligase IPR016495, p53_neg-reg_MDM_2/4 IPR036885, SWIB_MDM2_dom_sf IPR036443, Znf_RanBP2_sf |
PANTHERi | PTHR13844:SF15, PTHR13844:SF15, 2 hits |
PIRSFi | PIRSF006748, p53_MDM_2/4, 2 hits |
SUPFAMi | SSF47592, SSF47592, 1 hit SSF90209, SSF90209, 1 hit |
i Sequence
Sequence statusi: Fragment.
A7UKX9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM
60 70 80 90 100
KEDLDAGVSE HSGDWLDQDS VSDQFSVEFE VESLDSEDYS LSEEGQELSD
110 120 130 140
EDDEVYQVTV YQAGESDTDS FEEDPEISLA DYWKCTACNE MNPP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 144 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU076748 mRNA Translation: ABT17085.1 |
RefSeqi | NP_001138809.1, NM_001145337.2 NP_001265391.1, NM_001278462.1 |
Genome annotation databases
GeneIDi | 4193 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU076748 mRNA Translation: ABT17085.1 |
RefSeqi | NP_001138809.1, NM_001145337.2 NP_001265391.1, NM_001278462.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A7UKX9 |
Protocols and materials databases
DNASUi | 4193 |
Genome annotation databases
GeneIDi | 4193 |
Organism-specific databases
CTDi | 4193 |
Miscellaneous databases
BioGRID-ORCSi | 4193, 210 hits in 1135 CRISPR screens |
ChiTaRSi | MDM2, human |
GenomeRNAii | 4193 |
Family and domain databases
Gene3Di | 1.10.245.10, 1 hit |
InterProi | View protein in InterPro IPR015459, MDM2_E3_ligase IPR016495, p53_neg-reg_MDM_2/4 IPR036885, SWIB_MDM2_dom_sf IPR036443, Znf_RanBP2_sf |
PANTHERi | PTHR13844:SF15, PTHR13844:SF15, 2 hits |
PIRSFi | PIRSF006748, p53_MDM_2/4, 2 hits |
SUPFAMi | SSF47592, SSF47592, 1 hit SSF90209, SSF90209, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A7UKX9_HUMAN | |
Accessioni | A7UKX9Primary (citable) accession number: A7UKX9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | May 25, 2022 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |