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UniProtKB - A7UKX8 (A7UKX8_HUMAN)
Protein
Submitted name:
E3 ubiquitin-protein ligase Mdm2
Gene
MDM2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- negative regulation of apoptotic process Source: InterPro
- negative regulation of transcription by RNA polymerase II Source: InterPro
- protein ubiquitination Source: InterPro
- regulation of cell cycle Source: InterPro
Keywordsi
Biological process | Ubl conjugation pathwayARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: E3 ubiquitin-protein ligase Mdm2Submitted name: Mdm2Imported |
Gene namesi | Name:MDM2 Synonyms:mdm2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6973, MDM2 |
VEuPathDBi | HostDB:ENSG00000135679 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135679, Expressed in oviduct epithelium and 219 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 109 | SWIB/MDM2InterPro annotationAdd BLAST | 84 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 141 – 187 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 236 – 256 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 145 – 161 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 162 – 187 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 240 – 256 | Acidic residuesSequence analysisAdd BLAST | 17 |
Phylogenomic databases
GeneTreei | ENSGT00530000063539 |
Family and domain databases
Gene3Di | 1.10.245.10, 1 hit |
InterProi | View protein in InterPro IPR015459, MDM2_E3_ligase IPR016495, p53_neg-reg_MDM_2/4 IPR036885, SWIB_MDM2_dom_sf IPR003121, SWIB_MDM2_domain |
PANTHERi | PTHR13844:SF15, PTHR13844:SF15, 1 hit |
Pfami | View protein in Pfam PF02201, SWIB, 1 hit |
PIRSFi | PIRSF006748, p53_MDM_2/4, 2 hits |
SUPFAMi | SSF47592, SSF47592, 1 hit |
PROSITEi | View protein in PROSITE PS51925, SWIB_MDM2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 22 potential isoforms that are computationally mapped.Show allAlign All
A7UKX8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM
60 70 80 90 100
KEVLFYLGQY IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY
110 120 130 140 150
TMIYRNLVVV NQQESSDSGT SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS
160 170 180 190 200
HLVSRPSTSS RRRAISETEE NSDELSGERQ RKRHKSDSIS LSFDESLALC
210 220 230 240 250
VIREICCERS SSSESTGTPS NPDLDAGVYQ VTVYQAGESD TDSFEEDPEI
SLADYW
Computationally mapped potential isoform sequencesi
There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ00987 | MDM2_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 491 | Annotation score: | ||
G3XA89 | G3XA89_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 hCG_2014981 | 442 | Annotation score: | ||
E7EPE2 | E7EPE2_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 522 | Annotation score: | ||
J3KN53 | J3KN53_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 466 | Annotation score: | ||
F5GWH7 | F5GWH7_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 455 | Annotation score: | ||
Q9H4C5 | Q9H4C5_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 243 | Annotation score: | ||
A0A0C4DFR5 | A0A0C4DFR5_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 266 | Annotation score: | ||
F5H4Q8 | F5H4Q8_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 170 | Annotation score: | ||
A0A1B0GXJ6 | A0A1B0GXJ6_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 117 | Annotation score: | ||
A0A0A8KB88 | A0A0A8KB88_HUMAN | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 185 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 256 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC025423 Genomic DNA No translation available. EU076747 mRNA Translation: ABT17084.1 |
RefSeqi | NP_001138809.1, NM_001145337.2 |
Genome annotation databases
Ensembli | ENST00000393415.7; ENSP00000377067.3; ENSG00000135679.27 |
GeneIDi | 4193 |
UCSCi | uc058qrn.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC025423 Genomic DNA No translation available. EU076747 mRNA Translation: ABT17084.1 |
RefSeqi | NP_001138809.1, NM_001145337.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 1814 |
Protocols and materials databases
Antibodypediai | 3664, 1789 antibodies from 47 providers |
DNASUi | 4193 |
Genome annotation databases
Ensembli | ENST00000393415.7; ENSP00000377067.3; ENSG00000135679.27 |
GeneIDi | 4193 |
UCSCi | uc058qrn.1, human |
Organism-specific databases
CTDi | 4193 |
HGNCi | HGNC:6973, MDM2 |
OpenTargetsi | ENSG00000135679 |
VEuPathDBi | HostDB:ENSG00000135679 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00530000063539 |
Miscellaneous databases
BioGRID-ORCSi | 4193, 210 hits in 1135 CRISPR screens |
ChiTaRSi | MDM2, human |
GenomeRNAii | 4193 |
Gene expression databases
Bgeei | ENSG00000135679, Expressed in oviduct epithelium and 219 other tissues |
Family and domain databases
Gene3Di | 1.10.245.10, 1 hit |
InterProi | View protein in InterPro IPR015459, MDM2_E3_ligase IPR016495, p53_neg-reg_MDM_2/4 IPR036885, SWIB_MDM2_dom_sf IPR003121, SWIB_MDM2_domain |
PANTHERi | PTHR13844:SF15, PTHR13844:SF15, 1 hit |
Pfami | View protein in Pfam PF02201, SWIB, 1 hit |
PIRSFi | PIRSF006748, p53_MDM_2/4, 2 hits |
SUPFAMi | SSF47592, SSF47592, 1 hit |
PROSITEi | View protein in PROSITE PS51925, SWIB_MDM2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A7UKX8_HUMAN | |
Accessioni | A7UKX8Primary (citable) accession number: A7UKX8 Secondary accession number(s): E7EPE3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | May 25, 2022 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |