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UniProtKB - A7UKX7 (A7UKX7_HUMAN)
Protein
Submitted name:
Mdm2
Gene
mdm2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- negative regulation of apoptotic process Source: InterPro
- negative regulation of transcription by RNA polymerase II Source: InterPro
- protein ubiquitination Source: InterPro
- regulation of cell cycle Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Mdm2Imported |
Gene namesi | Name:mdm2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Expressioni
Gene expression databases
Bgeei | ENSG00000135679, Expressed in oviduct epithelium and 219 other tissues |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 82 – 118 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 24 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 82 – 104 | Acidic residuesSequence analysisAdd BLAST | 23 |
Family and domain databases
Gene3Di | 1.10.245.10, 1 hit |
InterProi | View protein in InterPro IPR015459, MDM2_E3_ligase IPR016495, p53_neg-reg_MDM_2/4 IPR036885, SWIB_MDM2_dom_sf |
PANTHERi | PTHR13844:SF15, PTHR13844:SF15, 1 hit |
PIRSFi | PIRSF006748, p53_MDM_2/4, 3 hits |
SUPFAMi | SSF47592, SSF47592, 1 hit |
i Sequence
Sequence statusi: Fragment.
A7UKX7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM
60 70 80 90 100
KEDLDAGVSE HSGDWLDQDS VSDQFSVEFE VESLDSEDYS LSEEGQELSD
110
EDDEDYWKCT SCNEMNPP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 118 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU076746 mRNA Translation: ABT17083.1 |
RefSeqi | NP_001138812.1, NM_001145340.2 |
Genome annotation databases
GeneIDi | 4193 |
UCSCi | uc058qrp.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU076746 mRNA Translation: ABT17083.1 |
RefSeqi | NP_001138812.1, NM_001145340.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A7UKX7 |
Protocols and materials databases
DNASUi | 4193 |
Genome annotation databases
GeneIDi | 4193 |
UCSCi | uc058qrp.1, human |
Organism-specific databases
CTDi | 4193 |
Miscellaneous databases
BioGRID-ORCSi | 4193, 210 hits in 1135 CRISPR screens |
ChiTaRSi | MDM2, human |
GenomeRNAii | 4193 |
Gene expression databases
Bgeei | ENSG00000135679, Expressed in oviduct epithelium and 219 other tissues |
Family and domain databases
Gene3Di | 1.10.245.10, 1 hit |
InterProi | View protein in InterPro IPR015459, MDM2_E3_ligase IPR016495, p53_neg-reg_MDM_2/4 IPR036885, SWIB_MDM2_dom_sf |
PANTHERi | PTHR13844:SF15, PTHR13844:SF15, 1 hit |
PIRSFi | PIRSF006748, p53_MDM_2/4, 3 hits |
SUPFAMi | SSF47592, SSF47592, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A7UKX7_HUMAN | |
Accessioni | A7UKX7Primary (citable) accession number: A7UKX7 Secondary accession number(s): A0A0A6YYM9, A0A0K0K1B6, F6RKA8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | May 25, 2022 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |