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Protein

Interferon epsilon

Gene

IFNE

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon epsilon
Short name:
IFN-epsilon
Alternative name(s):
Interferon epsilon-1
Gene namesi
Name:IFNE
Synonyms:IFNE1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031763322 – 193Interferon epsilonAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 163By similarity
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA7UHZ5
PRIDEiA7UHZ5

Expressioni

Gene expression databases

BgeeiENSSSCG00000005136 Expressed in 2 organ(s), highest expression level in lung
ExpressionAtlasiA7UHZ5 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005523

Structurei

3D structure databases

ProteinModelPortaliA7UHZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JB9C Eukaryota
ENOG4111BCG LUCA
GeneTreeiENSGT00920000149151
HOGENOMiHOG000230501
InParanoidiA7UHZ5
KOiK05442
OMAiCLPHRKN
OrthoDBiEOG091G0R2T
TreeFamiTF336177

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7UHZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MINKSFFEIM LVLLASSTGF SRELKLVLSQ QRRVNRESLK LLNKLQTSSI
60 70 80 90 100
QQCLPHRKNF LLPQKSMNPH QYQKQQALAI LHEMLQQIFS LFRAVISLDG
110 120 130 140 150
WEESHMEEFL VELHQQLEYL EALMRLQAEQ KSDTLCSENL TLQVKMYFQR
160 170 180 190
IRDYLENQDY SSCAWTIVRV EINRCLFFVF QLTGKLSKQG MEP
Length:193
Mass (Da):22,851
Last modified:October 2, 2007 - v1
Checksum:i60016CD37455C83E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU072421 mRNA Translation: ABU49642.1
RefSeqiNP_001098780.1, NM_001105310.1
XP_005660117.1, XM_005660060.2
UniGeneiSsc.69826

Genome annotation databases

EnsembliENSSSCT00000005664; ENSSSCP00000005523; ENSSSCG00000005136
GeneIDi100125969
KEGGissc:100125969

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU072421 mRNA Translation: ABU49642.1
RefSeqiNP_001098780.1, NM_001105310.1
XP_005660117.1, XM_005660060.2
UniGeneiSsc.69826

3D structure databases

ProteinModelPortaliA7UHZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000005523

Proteomic databases

PaxDbiA7UHZ5
PRIDEiA7UHZ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000005664; ENSSSCP00000005523; ENSSSCG00000005136
GeneIDi100125969
KEGGissc:100125969

Organism-specific databases

CTDi338376

Phylogenomic databases

eggNOGiENOG410JB9C Eukaryota
ENOG4111BCG LUCA
GeneTreeiENSGT00920000149151
HOGENOMiHOG000230501
InParanoidiA7UHZ5
KOiK05442
OMAiCLPHRKN
OrthoDBiEOG091G0R2T
TreeFamiTF336177

Gene expression databases

BgeeiENSSSCG00000005136 Expressed in 2 organ(s), highest expression level in lung
ExpressionAtlasiA7UHZ5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFNE_PIG
AccessioniPrimary (citable) accession number: A7UHZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 2, 2007
Last modified: November 7, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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