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Entry version 74 (16 Oct 2019)
Sequence version 1 (02 Oct 2007)
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Protein

Selection and upkeep of intraepithelial T-cells protein 1

Gene

Skint1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act by engaging a cell surface molecule on immature T-cells in the embryonic thymus. Plays a central role in mediating key epithelial-immune interactions by being involved in the selection of Vgamma5+Vdelta1+ T-cells, which constitute 90% of epidermal gammadelta T-cells.1 Publication

Miscellaneous

Encoded by one of the 11 copies of Skint genes clustered in the D1 region of the chromosome 4.
Humans and chimpanzees have a SKINT1-like (SKINT1L) gene with multiple inactivating mutations. All hominoid species have a common inactivating mutation, but that Old World monkeys such as olive baboons, green monkeys, cynomolgus macaques and rhesus macaques have apparently functional SKINT1L sequences, indicating that SKINT1L is inactivated in a common ancestor of hominoids.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Selection and upkeep of intraepithelial T-cells protein 1
Short name:
Skint-1
Alternative name(s):
Immunoglobulin-like and transmembrane domain-containing protein expressed in skin and thymus protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Skint1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3649627 Skint1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 246ExtracellularSequence analysisAdd BLAST223
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 284CytoplasmicSequence analysisAdd BLAST17
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 325ExtracellularSequence analysisAdd BLAST20
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Topological domaini347 – 364CytoplasmicSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500027010224 – 364Selection and upkeep of intraepithelial T-cells protein 1Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 123PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A7TZE6

PRoteomics IDEntifications database

More...
PRIDEi
A7TZE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skin and thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000089773 Expressed in 9 organ(s), highest expression level in zone of skin

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-59617N

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000124737

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A7TZE6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 141Ig-like V-typeAdd BLAST115
Domaini142 – 228Ig-like C1-typeAdd BLAST87

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SKINT family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J9CT Eukaryota
ENOG4111DQZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162562

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000063248

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A7TZE6

Identification of Orthologs from Complete Genome Data

More...
OMAi
IVFSSMC

Database of Orthologous Groups

More...
OrthoDBi
812118at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A7TZE6

TreeFam database of animal gene trees

More...
TreeFami
TF331083

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A7TZE6-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSTGLCFYG HCIVMFLLQM VTASSEPFIV NGLEGPVLAS LGGNLELSCQ
60 70 80 90 100
LSPPQQAQHM EIRWFRNLYT EPVHLYRDGK DMFGEIISKY VERTELLKDG
110 120 130 140 150
IGEGKVTLRI FNVTVDDDGS YHCVFKDGDF YEEHITEVKI TAINLQVQIH
160 170 180 190 200
VHPPNTKGVI VECHSGGWFP RPLMQWRDRR GEVIPAASKS HSQGRDKLFN
210 220 230 240 250
MKISLLISES FFQKVICCLQ NPLTGQEERT SVILSDAFFS WNRIWKMILG
260 270 280 290 300
IILSMMVVSI FVFSCLLHHE HKVCKWKWDA PWIKGLLIMT SSMVTVVLVM
310 320 330 340 350
VYLHMKQRVP VSDVHFELDT LWVEDISVIL CSLMVPATML VSYTYFRLKD
360
WCQHNHAQRV FTSN
Length:364
Mass (Da):41,792
Last modified:October 2, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBBAA9DD4CAD96DF5
GO
Isoform 2 (identifier: A7TZE6-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     273-289: VCKWKWDAPWIKGLLIM → GTYATWEQGRELVLHKP
     290-364: Missing.

Show »
Length:289
Mass (Da):32,946
Checksum:iA91CFEA211008441
GO
Isoform 3 (identifier: A7TZE6-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     236-255: DAFFSWNRIWKMILGIILSM → VVCYIMSIKVRMPRGSRGGN
     256-364: Missing.

Show »
Length:255
Mass (Da):28,752
Checksum:iB31020C6CF2F51E4
GO
Isoform 4 (identifier: A7TZE6-4) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     142-163: AINLQVQIHVHPPNTKGVIVEC → GGNGSFRGFYESTFFNSSGSER
     164-364: Missing.

Show »
Length:163
Mass (Da):18,301
Checksum:iB17C9C1BD9690182
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22T → I in ABS30712 (PubMed:18408721).Curated1
Sequence conflicti22T → I in ABS30713 (PubMed:18408721).Curated1
Sequence conflicti27P → Q in ABS30712 (PubMed:18408721).Curated1
Sequence conflicti27P → Q in ABS30713 (PubMed:18408721).Curated1
Sequence conflicti39A → V in ABS30712 (PubMed:18408721).Curated1
Sequence conflicti39A → V in ABS30713 (PubMed:18408721).Curated1
Sequence conflicti171R → Q in ABS30712 (PubMed:18408721).Curated1
Sequence conflicti171R → Q in ABS30713 (PubMed:18408721).Curated1
Sequence conflicti187A → T in ABS30712 (PubMed:18408721).Curated1
Sequence conflicti187A → T in ABS30713 (PubMed:18408721).Curated1
Sequence conflicti203I → M in ABS30712 (PubMed:18408721).Curated1
Sequence conflicti203I → M in ABS30713 (PubMed:18408721).Curated1
Sequence conflicti246K → T in ABS30712 (PubMed:18408721).Curated1
Sequence conflicti246K → T in ABS30713 (PubMed:18408721).Curated1
Sequence conflicti250 – 252GII → SIM in ABS30712 (PubMed:18408721).Curated3
Sequence conflicti250 – 252GII → SIM in ABS30713 (PubMed:18408721).Curated3
Sequence conflicti269H → Y in ABS30712 (PubMed:18408721).Curated1
Sequence conflicti269H → Y in ABS30713 (PubMed:18408721).Curated1
Sequence conflicti275 – 276KW → RC in ABS30712 (PubMed:18408721).Curated2
Sequence conflicti275 – 276KW → RC in ABS30713 (PubMed:18408721).Curated2
Sequence conflicti290T → I in ABS30712 (PubMed:18408721).Curated1
Sequence conflicti290T → I in ABS30713 (PubMed:18408721).Curated1
Sequence conflicti293M → V in ABS30712 (PubMed:18408721).Curated1
Sequence conflicti293M → V in ABS30713 (PubMed:18408721).Curated1
Sequence conflicti305M → K in ABS30712 (PubMed:18408721).Curated1
Sequence conflicti305M → K in ABS30713 (PubMed:18408721).Curated1
Sequence conflicti311V → I in ABS30712 (PubMed:18408721).Curated1
Sequence conflicti311V → I in ABS30713 (PubMed:18408721).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The strain FVB/NTac displays a selective deficiency for epidermal Vgamma5+Vdelta1+ T-cells due to a mutation that creates premature codon stop at position 324.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti324 – 364Missing in strain: FVB/NTac. 1 PublicationAdd BLAST41

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034871142 – 163AINLQ…VIVEC → GGNGSFRGFYESTFFNSSGS ER in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_034872164 – 364Missing in isoform 4. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_034873236 – 255DAFFS…IILSM → VVCYIMSIKVRMPRGSRGGN in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_034874256 – 364Missing in isoform 3. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_034875273 – 289VCKWK…GLLIM → GTYATWEQGRELVLHKP in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_034876290 – 364Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF494889 mRNA Translation: ABS30711.1
EF494890 mRNA Translation: ABS30712.1
EF494891 mRNA Translation: ABS30713.1
EU099296 mRNA Translation: ABU87894.1
EU099297 mRNA Translation: ABU87895.1
EU099298 mRNA Translation: ABU87896.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51267.1 [A7TZE6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001096132.1, NM_001102662.1 [A7TZE6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000117379; ENSMUSP00000124545; ENSMUSG00000089773 [A7TZE6-3]
ENSMUST00000161389; ENSMUSP00000125313; ENSMUSG00000089773 [A7TZE6-2]
ENSMUST00000162158; ENSMUSP00000124737; ENSMUSG00000089773 [A7TZE6-1]
ENSMUST00000162885; ENSMUSP00000125625; ENSMUSG00000089773 [A7TZE6-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
639781

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:639781

UCSC genome browser

More...
UCSCi
uc008udq.1 mouse [A7TZE6-1]
uc009vcw.1 mouse [A7TZE6-4]
uc012dip.1 mouse [A7TZE6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF494889 mRNA Translation: ABS30711.1
EF494890 mRNA Translation: ABS30712.1
EF494891 mRNA Translation: ABS30713.1
EU099296 mRNA Translation: ABU87894.1
EU099297 mRNA Translation: ABU87895.1
EU099298 mRNA Translation: ABU87896.1
CCDSiCCDS51267.1 [A7TZE6-1]
RefSeqiNP_001096132.1, NM_001102662.1 [A7TZE6-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N4INMR-A24-141[»]
SMRiA7TZE6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-59617N
STRINGi10090.ENSMUSP00000124737

Proteomic databases

PaxDbiA7TZE6
PRIDEiA7TZE6

Genome annotation databases

EnsembliENSMUST00000117379; ENSMUSP00000124545; ENSMUSG00000089773 [A7TZE6-3]
ENSMUST00000161389; ENSMUSP00000125313; ENSMUSG00000089773 [A7TZE6-2]
ENSMUST00000162158; ENSMUSP00000124737; ENSMUSG00000089773 [A7TZE6-1]
ENSMUST00000162885; ENSMUSP00000125625; ENSMUSG00000089773 [A7TZE6-4]
GeneIDi639781
KEGGimmu:639781
UCSCiuc008udq.1 mouse [A7TZE6-1]
uc009vcw.1 mouse [A7TZE6-4]
uc012dip.1 mouse [A7TZE6-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
639781
MGIiMGI:3649627 Skint1

Phylogenomic databases

eggNOGiENOG410J9CT Eukaryota
ENOG4111DQZ LUCA
GeneTreeiENSGT00940000162562
HOGENOMiHOG000063248
InParanoidiA7TZE6
OMAiIVFSSMC
OrthoDBi812118at2759
PhylomeDBiA7TZE6
TreeFamiTF331083

Miscellaneous databases

Protein Ontology

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PROi
PR:A7TZE6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000089773 Expressed in 9 organ(s), highest expression level in zone of skin

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKIT1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7TZE6
Secondary accession number(s): A7TZE7
, A7XUW2, A7XUW8, A7XUX1, A9XK90
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 2, 2007
Last modified: October 16, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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