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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei196PROSITE-ProRule annotation1
Active sitei404PROSITE-ProRule annotation1
Active sitei468PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:Kpol_1041p46
OrganismiVanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
Taxonomic identifieri436907 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeVanderwaltozyma
Proteomesi
  • UP000000267 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 616LumenalSequence analysisAdd BLAST594
Transmembranei617 – 637HelicalSequence analysisAdd BLAST21
Topological domaini638 – 713CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000041195123 – 713Pheromone-processing carboxypeptidase KEX1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA7TLB3

Interactioni

Protein-protein interaction databases

STRINGi436907.XP_001644846.1

Structurei

3D structure databases

ProteinModelPortaliA7TLB3
SMRiA7TLB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi554 – 599Poly-AspAdd BLAST46
Compositional biasi651 – 659Poly-Ser9

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
InParanoidiA7TLB3
KOiK01288
OrthoDBiEOG092C255X
PhylomeDBiA7TLB3

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7TLB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVSYKLLSL ITLLFVAQCT TGLLKQDDYV VRPDLLPGIS SIKDKALIPK
60 70 80 90 100
MYAGHIPLNL QKTTDENENT DESDSNSNTN YFFWKFQHQS VESPNLIFWL
110 120 130 140 150
NGGPGCSSMD GALVETGPFR VDKNGKLYPN EGSWHSRGDL VYIDQPIGTG
160 170 180 190 200
LSTSAAIPNL LDDLKEVSDN FILFLENYFT IFPNDLDKDI IIAGESYAGQ
210 220 230 240 250
YIPFFAKAIK EYNQKISDNK KKINLRMLLI GNGWIDPITQ SLSYLPFAIE
260 270 280 290 300
KNLVGKDTPD FETLLKAHEK CQNKINSISE DDNSFSHEEC ESIINMLVSV
310 320 330 340 350
TKDNSPNVKS NEVCINIYDF NLRDSFPACG ANWPIDVSHV AKFFSTPGVI
360 370 380 390 400
EALNLNAEEV PRWKECNYDV LNHLTNPVSK PSVRLLPELL ESGIEIILFN
410 420 430 440 450
GENDLVCNNK GITDMISKLT WNGATGFSDK VQKYEWLFRD LTKDTEEPAG
460 470 480 490 500
TVTFDRNLTF ISVYNASHMV AYDKSIVARG ILDIYLDNVM LVEKETDSPD
510 520 530 540 550
VLISTNEPTF SDIEEEELDG EKEDEKDGVT EGDGEKSDTD EGKDTDKGKD
560 570 580 590 600
EKNDDDDDDD DDSDDDSDDD DDDDDDDDDD DDDDDDSDDD DDDDDDSDDN
610 620 630 640 650
EKDDKSESET KTHPKAKIAL LLLLFISVFG ITGSQALRQR NFQFRRAPLT
660 670 680 690 700
SNSFSSSSSP NDPSNWDSND DFDFDIENDP LPSTNNKHKA AKKKKDYVSI
710
PSDIDESFEL AEI
Length:713
Mass (Da):80,063
Last modified:October 2, 2007 - v1
Checksum:i3C8951CB2FB6041C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS480413 Genomic DNA Translation: EDO16988.1
RefSeqiXP_001644846.1, XM_001644796.1

Genome annotation databases

EnsemblFungiiEDO16988; EDO16988; Kpol_1041p46
GeneIDi5545175
KEGGivpo:Kpol_1041p46

Entry informationi

Entry nameiKEX1_VANPO
AccessioniPrimary (citable) accession number: A7TLB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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