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Entry version 72 (12 Aug 2020)
Sequence version 1 (02 Oct 2007)
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Protein
Submitted name:

Predicted protein

Gene

v1g248100

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Predicted proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:v1g248100Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNematostella vectensis (Starlet sea anemone)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri45351 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001593 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
45351.EDO31207

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini215 – 248TPR_REGIONInterPro annotationAdd BLAST34
Domaini248 – 315TPR_REGIONInterPro annotationAdd BLAST68
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati248 – 281TPRPROSITE-ProRule annotationAdd BLAST34
Repeati282 – 315TPRPROSITE-ProRule annotationAdd BLAST34
Domaini477 – 586TPR_REGIONInterPro annotationAdd BLAST110
Repeati477 – 510TPRPROSITE-ProRule annotationAdd BLAST34
Repeati553 – 586TPRPROSITE-ProRule annotationAdd BLAST34
Repeati698 – 731TPRPROSITE-ProRule annotationAdd BLAST34
Domaini712 – 840TPR_REGIONInterPro annotationAdd BLAST129
Repeati807 – 840TPRPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni118 – 161DisorderedSequence analysisAdd BLAST44
Regioni325 – 395DisorderedSequence analysisAdd BLAST71
Regioni455 – 474DisorderedSequence analysisAdd BLAST20
Regioni619 – 654DisorderedSequence analysisAdd BLAST36
Regioni856 – 965DisorderedSequence analysisAdd BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili171 – 193Sequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi124 – 146PolarSequence analysisAdd BLAST23
Compositional biasi332 – 352PolarSequence analysisAdd BLAST21
Compositional biasi619 – 647PolarSequence analysisAdd BLAST29
Compositional biasi917 – 957PolarSequence analysisAdd BLAST41

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1124, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008405_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A7SYL2

Identification of Orthologs from Complete Genome Data

More...
OMAi
CINDATR

Database of Orthologous Groups

More...
OrthoDBi
1070087at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025986, RPAP3-like_C
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13877, RPAP3_C, 1 hit
PF13181, TPR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028, TPR, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 6 hits
PS50293, TPR_REGION, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A7SYL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTEGVYGTT KAGIPLHHLD YKYVGSCSDG KELEKILKVL RSGEEGTYPE
60 70 80 90 100
LIEFTEKRLE EVMPKSRALR KDLPAKSYRD LGKPEQEELV NDIEEWMTDI
110 120 130 140 150
SQLDSKLKTN SDAEAISDFL PPVRSSKTIG STSSPSQATN TFDRPQGKQK
160 170 180 190 200
GPVAPRSYTE WDKFDPDEEV KLLEEKEKQQ VKEKKEKARI NTREAKLPTN
210 220 230 240 250
VKTPAKTDQE LTFLANREKD KGNDAFRSGD YKESLVYYTR SIELKPTAAS
260 270 280 290 300
YNNRAMAEIK LSEYAKAIED CNTVIFLEPD NLKAFLRRAI AQKQTGKVQA
310 320 330 340 350
AKKDLNKVLE IEPNNKRAKE LLEEITKENS QGKVAKEAQS KSESNPTSRK
360 370 380 390 400
QGGGQRLKIV EVDEEEDDEE ETEAADEEKI KTVNGLNGVE RPAEKPMTNG
410 420 430 440 450
VIEGALAKSG AENGLEFTSQ NNRAKKDLGA NIASLDTSSI AAPLSVNQNN
460 470 480 490 500
QVAEKPPMEV ASQPAPPSPP RDLPNLAVRA KDEGMRLYKI GRYAEAVEKY
510 520 530 540 550
SQAIDVLWKD KSHFKSALAS LLYNRASCLG RIGDASGCVK DCTSSLNLIP
560 570 580 590 600
DSLKAHLKRA EQFEHLEKYK EAHFDYQAVL RIDPANQQAL RSNNRVNSHL
610 620 630 640 650
LSVYGPTWRT KITEAKPTSA TSQALLDNEP QSTPASVYLS SGPQKVNKVE
660 670 680 690 700
TKPEPLKKSV AERFGECKER GNNFVKQSKR CPTPSKAFLI GPKAPFRLYP
710 720 730 740 750
SLRKTIAPIT KGKHNEAVSC YTECISINPN EVASYTNRAL CYLKLDKIFV
760 770 780 790 800
ELNIKLNQIF GELNIKLNQI FGELNIKLNQ IFGELNIKND LAEKDANTAL
810 820 830 840 850
GLQPDNVKAL YRRALARKAL GKYDTAAKDL LSLVKIDSKN MSGKKELDTV
860 870 880 890 900
LELCRKERRE TQKSQPKGKT NSRPPANKEK PASGKTTAEG NNVRRRRVVI
910 920 930 940 950
DEVNNDDEDS EEENASSKKT PCPASKKAPP NNQQAKKGGK DQPSKQAGNT
960 970 980 990 1000
TPTRGTKQKK IHLNKPTPYD FFQAWNTVRR NDLTSYAEIL RQVEPKMLPK
1010 1020 1030 1040 1050
ILSNKLDADM FRNMIGAIST QLIPNGEEKL SFQILQNVCQ AQRFDMAIMF
1060 1070 1080 1090
LGRQDIQDLQ DLFAWLGSSQ KLLSSIDSKT FTIVKNKYNA
Length:1,090
Mass (Da):121,846
Last modified:October 2, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89AA62917B73864A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS469926 Genomic DNA Translation: EDO31207.1

NCBI Reference Sequences

More...
RefSeqi
XP_001623307.1, XM_001623257.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
EDO31207; EDO31207; NEMVEDRAFT_v1g248100

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469926 Genomic DNA Translation: EDO31207.1
RefSeqiXP_001623307.1, XM_001623257.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi45351.EDO31207

Genome annotation databases

EnsemblMetazoaiEDO31207; EDO31207; NEMVEDRAFT_v1g248100

Phylogenomic databases

eggNOGiKOG1124, Eukaryota
HOGENOMiCLU_008405_1_0_1
InParanoidiA7SYL2
OMAiCINDATR
OrthoDBi1070087at2759

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR025986, RPAP3-like_C
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF13877, RPAP3_C, 1 hit
PF13181, TPR_8, 2 hits
SMARTiView protein in SMART
SM00028, TPR, 8 hits
SUPFAMiSSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005, TPR, 6 hits
PS50293, TPR_REGION, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA7SYL2_NEMVE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7SYL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: August 12, 2020
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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